Jump to content

PubMed RSS Feed - -Cathelicidin LL-37 Ignites Primed NLRP3 Inflammasomes in Rosacea


Recommended Posts

J Invest Dermatol. 2021 Sep 23:S0022-202X(21)01313-0. doi: 10.1016/j.jid.2021.04.024. Online ahead of print.


Microbes and commensal mites contribute to the development of inflammation and neurovascular dysregulation in rosacea. Cathelicidin family proteins are epithelial antimicrobial peptides expressed in higher-order mammals. In humans, mature LL-37 is cleaved from its precursor in response to microbial infection, UV light, and injury. In their new article in the Journal of Investigative Dermatology, Yoon et al. expand on existing evidence supporting LL-37 proinflammatory activity in lipopolysaccharide (LPS)- and UV-primed models of rosacea. They show in vitro that LL-37 promotes NLRP3-mediated inflammasome activation through lysosomal destabilization in the presence of LPS and that the injection of LL-37 in vivo leads to skin inflammation that is abrogated by direct NLRP3 inhibition and homozygous knockout in a murine model.

PMID:34565561 | DOI:10.1016/j.jid.2021.04.024

{url} = URL to article

More information on Cathelicidin Peptide LL-37

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Create New...

Important Information

Terms of Use