Chronic Mucocutaneous Candidiasis and Rosacea

[Guide]

Chronic Mucocutaneous Candidiasis (CMC) has been associated with "Rosacea-Like Demodicosis" in at least one paper. 

CMC is "is an immune disorder of T cells, it is characterized by chronic infections with Candida that are limited to mucosal surfaces, skin, and nails.  It can also be associated with other types of infections, such as human papilloma virus. An association with chromosome 2 has been identified." [1]

"Heterozygous missense STAT1 mutations leading to a gain of function (GOF) are the most frequent genetic cause of chronic mucocutaneous candidiasis (CMC). We describe the case of a patient presenting a new GOF mutation of STAT1 with the clinical symptoms of CMC, recurrent pneumonia, and persistent central erythema with papulopustules with ocular involvement related to rosacea-like demodicosis.' [2]

"Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family." [3]

"Rosacea-Like Demodicosis" is a synonym for demodectic rosacea. 

CMC has now been added to the list of systemic cormorbidities in rosacea. 

End Notes

All images courtesy of Wikimedia Commons

[1] Chronic Mucocutaneous Candidiasis, Wikipedia

[2] Front Immunol. 2021; 12: 760019.
Case Report: A New Gain-of-Function Mutation of STAT1 Identified in a Patient With Chronic Mucocutaneous Candidiasis and Rosacea-Like Demodicosis: An Emerging Association
Martin Martinot, Anne Sophie Korganow,  Mathieu Wald,  Julie Second,  Elodie Birckel,  Antoine Mahé,  Laurent Souply,  Mahsa Mohseni-Zadeh,  Laure Droy,  Julien Tarabeux,  Satoshi Okada,  Mélanie Migaud,  Anne Puel, Aurelien Guffroy 

[3] STAT1, Wikipedia