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PubMed RSS Feed - -Benefits and safety of Oxymetazoline cream 1% on rosacea associated erythema: A systematic review and analysis of clinical evidence


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J Cosmet Dermatol. 2022 Oct 13. doi: 10.1111/jocd.15467. Online ahead of print.


BACKGROUND: Facial persistent erythema is recognized as difficult feature to treat in rosacea. Topical Oxymetazoline cream 1% has been used to treat persistent facial erythema in rosacea patients for some years.

OBJECTIVE: To quantitatively synthesize the benefits and harms of Oxymetazoline cream 1% in real-world clinical management of treatment response and adverse events.

METHODS: The clinical researches before june1st ,2022 published on online databases including PubMed, Web of Science, Embase and Cochrane Library were meta-analyzed.

RESULTS: A total of 2298 participants were included, and the improvement rate of two-grade Clinician Erythema Assessment score (CEA) and Subject Self-Assessment for rosacea facial redness score (SSA) in Oxymetazoline group was 38% (95%CI 28-48) and 25% (95%CI 22-27), respectively at the 4th week of the dosing. The comprehensive rate of treatment-related TEAEs in Oxymetazoline group was 7% (95%CI 5-8). The rate of stinging/burning was 15% (95%CI 10-19), pruritus was 15% (95%CI 9-22), dryness was 23% (95%CI 18-28), and scaling was 17% (95%CI 12-22) in analysis of dermal tolerability. And topical Oxymetazoline cream 1.0% presented a very low rebound rate of erythema (1%, 95%CI 0-2).

CONCLUSIONS: These real-world data on Oxymetazoline cream 1% in rosacea associated erythema may help making clinic decision and informing treatment expectations, and more clinic trials on longer-term dosing or the combination treatment with oral medication and energy-based therapy are worth exploring.

PMID:36237138 | DOI:10.1111/jocd.15467

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