PubMed RSS Feed - -Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea

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Int J Biol Sci. 2023 Oct 2;19(16):5160-5173. doi: 10.7150/ijbs.86207. eCollection 2023.

ABSTRACT

Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4⁺ T cells of both rosacea patients and experimental mice. Specifically, AQP3 deletion blocked the development of rosacea-like skin inflammation in model mice with LL37-induced rosacea-like disease. We also present mechanistic evidence showing that AQP3 was essential to the activation of NF-κB signaling and subsequent production of disease-characteristic chemokines in keratinocytes. Moreover, we show that AQP3 was upregulated during T cell differentiation and promotes helper T (Th) 17 differentiation possibly via the activation of STAT3 signaling. Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4⁺ T cells acted synergistically and contributed to the inflammation in rosacea.

PMID:37928265 | PMC:PMC10620828 | DOI:10.7150/ijbs.86207

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