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One of the theories of the cause of rosacea is an overactive immune system

"In a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman-Yassky of Mount Sinai Medical School [RRDi MAC Member], discovered that an arm of the immune system -- the Th17 pathway -- in these patients is way too active, and the higher its activity, the worse the disease severity....The drug Paller will test, secukinumab, has already been highly effective in psoriasis, a more common skin disorder with an increase in this Th17 pathway, leading to inflammation and scaling. And with Paller's new discovery, she thinks the drug could be even more helpful in ichthyosis because the overactive immune pathway was actually more strongly correlated with ichthyosis than with psoriasis."

Research finally reveals reason for perplexing red skin disease
Science Daily, September 20, 2016


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