Diabetes and Rosacea

[Guide]

"The GWAS by Chang et al., also revealed that patients with rosacea shared a genetic locus with type 1 diabetes mellitus; this association was further confirmed by a population-based study as well. A recent study also revealed the presence of insulin resistance in rosacea, demonstrating significantly higher fasting blood glucose levels in patients with rosacea than in controls. As increased glucose intolerance along with dyslipidemia and hypertension are the factors that comprise metabolic syndrome, this association in rosacea might be related to cathelicidin, oxidative stress and endoplasmic reticulum (ER) stress, which are implicated in the pathogenesis of both rosacea and metabolic disorders. However, the advanced state of diabetes mellitus, which is associated with longer disease duration or high hemoglobin A1c levels, has conversely been recently associated with a decreased risk of rosacea. Thus, the underlying mechanism involved in this paradoxical association remains to be clarified."
Int J Mol Sci. 2016 Sep; 17(9): 1562.
Published online 2016 Sep 15. doi:  10.3390/ijms17091562, PMCID: PMC5037831
Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition
Yu Ri Woo, Ji Hong Lim, Dae Ho Cho, and Hyun Jeong Park,