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Skin steroidogenesis in health and disease.

Rev Endocr Metab Disord. 2016 Oct 20;

Authors: Nikolakis G, Stratakis CA, Kanaki T, Slominski A, Zouboulis CC

Abstract
The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.

PMID: 27761789 [PubMed - as supplied by publisher]

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