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Minocycline as Good as Doxycycline for Rosacea


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"Minocycline 100mg is non-inferior to doxycycline 40mg in efficacy over a 16- week treatment period. Furthermore, at follow up, RosaQoL scores and PaGA were statistically significantly more improved in the minocycline group than in the doxycycline group, and minocycline 100mg gives longer remission than doxycycline 40mg. In this study there was no significant difference in safety between these treatments, however, based on previous literature minocycline has a lower risk/benefit ratio than doxycycline. Minocycline 100mg may be a good alternative treatment for those patients who, for any reason, are unable or unwilling to take doxycycline 40mg."

Br J Dermatol. 2016 Oct 31. doi: 10.1111/bjd.15155. 
DOMINO, doxycycline 40mg vs minocycline 100mg in the treatment of rosacea: a randomised, single blinded, non-inferiority trial, comparing efficacy and safety.
van der Linden MM, van Ratingen AR, van Rappard DC, Nieuwenburg SA, Spuls PI.

Monocycline "is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group....Minocycline is the most lipid-soluble of the tetracycline-class antibiotics, giving it the greatest penetration into the prostate and brain, but also the greatest amount of central nervous system (CNS)-related side effects, such as vertigo." Wikipedia

Orał Minocycline (minolira) has been approved for treating acne which is a timed released minocycline hydrochloride. 

Oracea, a frequently prescribed timed released doxycycline (another tetracycline), by Galderma, is reportedly used by many rosacea sufferers to control their rosacea. It may be possible that minolira may be approved for rosacea. 

Topical Minocycline
There have been a number of pharmaceutical companies in clinical trials with developing a monocycline topical which we have been following for some time now in this thread, and Zilxi has been announced as the front runner in this race. 

Minocycline-Induced Lupus

If you are not aware of minocycline-induced lupus, you are now informed. 

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