Jump to content

PubMed RSS Feed - -Immune-related alopecia (areata and universalis-type) in cancer patients receiving immune checkpoint inhibitors.


rss

Recommended Posts

Immune-related alopecia (areata and universalis-type) in cancer patients receiving immune checkpoint inhibitors.

Br J Dermatol. 2016 Dec 11;:

Authors: Zarbo A, Belum VR, Sibaud V, Oudard S, Postow MA, Hsieh JJ, Motzer RJ, Busam KJ, Lacouture ME

Abstract
CTLA-4, PD-1, and PD-L1 monoclonal antibodies, commonly known as immune checkpoint inhibitors, are used for the treatment of various malignancies. The mechanism of action involves the inhibition of negative regulators of immune activation, which results in many patients developing immune-related adverse events (irAEs) including endocrinopathies, pneumonitis, colitis, hepatitis and dermatologic events. Dermatologic irAEs include maculopapular rash, pruritus, vitiligo, blistering disorders, mucocutaneous lichenoid eruptions, rosacea, and exacerbation of psoriasis. Alopecia secondary to immune checkpoint inhibitors has been reported in 1.0-1.6% of patients. We characterize four cases of alopecia areata (AA) secondary to immune checkpoint inhibitors with images, histology, and concomitant nail findings, including the first report of anti-PD-L1 therapy induced AA, and a review of the literature. Patients treated with immune checkpoint inhibitors, singly or in combination, who developed partial or complete alopecia (areata and universalis-type) during treatment for their underlying cancer were analyzed (N=4). Three (75%) patients had AA, while one (25%) had universalis-type. Two patients had resolution after topical, oral, or intralesional therapies and one patient had resolution after discontinuation of immunotherapy; all regrown hair exhibited poliosis. One (25%) patient had coincident onychodystrophy. This report describes a series of four patients who developed partial or complete alopecia (i.e. areata and universalis-type) during treatment with immune-checkpoint inhibitor therapies for cancer. Recognition and management of hair-related irAEs are important for pretherapy counseling and interventions that would contribute to maintaining optimal health-related quality of life. This article is protected by copyright. All rights reserved.

PMID: 27943234 [PubMed - as supplied by publisher]

{url} = URL to article

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

×
×
  • Create New...