OnabotulinumtoxinA injections

[Guide]

"Anecdotal results of reduced erythema and acne with the use of OnabotulinumtoxinA (Botox®, Allergan, Irvine, CA, USA) for cosmetic purposes led Dayan et al to experiment further in 13 patients with rosacea. Over the course of 2 years, patients received intralesional microdroplet injections (0.05 mL) of onabotulinumtoxinA in a dilution of 7 mL of saline solution per 100 units. The results indicated significant reduction in erythema and flushing of the affected area 2–4 weeks after treatment. Their predecessors reported similar results after a 26-year-old male was injected with 10 units of onabotulinumtoxinA at 1 cm intervals into one cheek."

Clin Cosmet Investig Dermatol. 2015; 8: 159–177.
Published online 2015 Apr 7. doi:  10.2147/CCID.S58940
PMCID: PMC4396587
Update on the management of rosacea
Allison P Weinkle, Vladyslava Doktor, and Jason Emer

We need more studies on this.