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Monitoring structural changes in Demodex mites under topical Ivermectin in Rosacea by means of Reflectance confocal microscopy: a case series.

J Eur Acad Dermatol Venereol. 2016 Dec 15;:

Authors: Ruini C, Sattler E, Hartmann D, Reinholz M, Ruzicka T, Braunmühl TV

Abstract
Rosacea is a common inflammatory disease, mainly affecting the face and with significant impact on patients' life quality. Just recently, topical Ivermectin (Soolantra(®) 10mg/g Crème) has been introduced in the treatment of rosacea thanks to its double anti-parasitic and anti-inflammatory activity, resulting in a reduction of papulo-pustular manifestations, blepharitis and cutaneous demodicosis.(1) Although the role of the human skin commensal Demodex folliculorum (DF) in the pathogenesis of the disease is still debated(2) , numerous studied reported an abnormal increase in the density of mites (>5 mites/cm(2) ) in patients affected by papulo-pustular rosacea, measured by regular and standardized superficial skin biopsy, skin scraping, PCR or reflectance confocal microscopy (RCM)(3-6) . This article is protected by copyright. All rights reserved.

PMID: 27976437 [PubMed - as supplied by publisher]

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