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Continuous Improvement With Ivermectin Long-term Use - Gets Worse Before it Gets Better


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"This meta-analysis gives strong evidence that IVM 1% cream is the most effective topical treatment above other alternatives and it satisfies the impairment of social and working life with a sustained better QoL." [1]

"Topical ivermectin cream 1% given daily is an effective and safe therapy against rosacea." [2]

Gets Worse Before it Gets Better

In many anecdotal reports from users of Soolantra [ivermectin] complain that it gets worse before it gets better. This may cause some to stop the treatment. It is not uncommon for Soolantra users to say the first week or more of Soolantra use their rosacea actually got worse. This might be the result of the ivermectin killing the mites. However, in time, usually within a month, you will know whether or not Soolantra is improving your rosacea. If you do stop the treatment you should notify your physician. 

If you think you may be allergic to Soolantra, a good test is to dab a little Soolantra on the inside of your wrist and see if within a few hours whether your skin turns red and gets inflamed. If so, you may be allergic to Soolantra and you should notify your physician of this fact. If not, then just because your facial treatment of rosacea using Soolantra gets worse before it gets better, the only way is to continue your facial treatment of topical Soolantra and usually within a month you will see some improvement. However, total clearance takes time, at least 12 weeks or longer. 

"After 16 weeks, blepharitis (P = .004), and conjunctival redness (P = .008) had strongly improved, and grade 1 was seen in all patients until the end of follow-up." "The follow-up was 8 months (range: 5-12 months)." [2] 

On the Soolantra web site there are clinical studies indicating that it may take at least 12 weeks or longer to see positive results from Soolantra. Look for the following: 


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End Notes

[1] Dermatol Ther. 2019 Dec 20;:e13203
Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta-analysis.
Husein-ElAhmed H, Steinhoff M

[2] Ocul Immunol Inflamm. 2020 Apr 07;:1-5
Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea.
Sobolewska B, Doycheva D, Deuter CM, Schaller M, Zierhut M

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