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TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.

J Invest Dermatol. 2017 Apr;137(4):801-804

Authors: Chen Y, Moore CD, Zhang JY, Hall RP, MacLeod AS, Liedtke W

Abstract
Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 a translational-medical target in rosacea. However, signaling mechanisms causing increased expression of TRPV4 await elucidation. Moreover, we ask whether TRPV4-mediated Ca(++)-influx evokes mast cell degranulation.

PMID: 28340683 [PubMed - in process]

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