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Ivermectin Treatment Prevents the Augmentation of the Cathelicidin Immune Pathway

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"Overall, the results of this study suggest that ivermectin treatment prevents the augmentation of the cathelicidin immune pathway, which has a positive impact on the downstream inflammatory pathway (e.g., decreased IL-8, IL-6 and CCL2 secretion). These results suggest that ivermectin can prevent the inflammatory effects of rosacea triggered by abnormal LL-37 processing, through the inhibition of KLK5and CAMP gene expression in the epidermis."

Dermatol Ther (Heidelb). 2017 Jun; 7(2): 213–225.
Published online 2017 Feb 27. doi:  10.1007/s13555-017-0176-3
PMCID: PMC5453918
Topical Treatment of Rosacea with Ivermectin Inhibits Gene Expression of Cathelicidin Innate Immune Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin Models
Séverine Thibaut de Ménonville,corresponding author Carine Rosignoli, Estelle Soares, Manon Roquet, Béatrice Bertino, Jean-Paul Chappuis, Claire Defoin-Platel/Chaussade, and David Piwnica

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