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Endothelyol for Erythematotelangiectatic Rosacea

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A study published in 2015 by a group in Europe that "proposed a dermocosmetic active ingredient to mitigate some aspects of the rosacea and particularly for erythematotelangiectatic rosacea [ETR]." Using a patented process of three basic ingredients, rosmarinic acid, gallic acid, and caffeic acid (hence the acronym RGC with the trade name Endothelyol) this group formulated a serum (calling it RGC Serum) to treat ETR and tested it on volunteers. The report concluded, "these studies have shown that RGC active could be a dermocosmetic help, especially for erythematotelangiectatic rosacea armamentarium. Indeed, 2% of RGC topically applied on face for 28 days improved erythematotelangiectatic rosacea symptoms either by decreasing them (in half of the volunteers, vessels are less visible) or by limiting their development (any neovessels seen). RGC acts by decreasing inflammation (inhibition of IL-8 and TNF release), decreasing degranulation of mast cells (inhibition of histamine release), and limiting the angiogenesis process (inhibition of VEGF production and neovessel formation)."

Combination of new multifunctional molecules for erythematotelangiectatic rosacea disorder
Hanane Chajra, Mahdi Nadim, Daniel Auriol, Kuno Schweikert, Fabrice Lefevre
Accepted for publication 6 August 2015
Published 1 October 2015 Volume 2015:8 Pages 501—510
DOI https://doi.org/10.2147/CCID.S92326

ProTec Ingredia, part of the LPC Group, reports on its website that "Endothelyol is an active ingredient to reduce skin redness and rosacea. It works by targeting VEGF, Histamine, TNF-alpha, Interleukin 8 and Prostaglandin E2." You can download a pdf of this product to review which points to Induchem as the manufacturer and sells Endothelyol to cosmetic companies on this pageGivaudan Active Beauty apparently sells Endothlyol according to Coptis and Prospector.  

One product that contains Endothelyol is SVR Sensifine AR

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