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Rosacea and its association with enteral microbiota in Korean females.

Exp Dermatol. 2017 Jun 21;:

Authors: Nam JH, Yun Y, Kim HS, Kim HN, Jung HJ, Chang Y, Ryu S, Shin H, Kim HL, Kim WS

Abstract
BACKGROUND: Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain.
OBJECTIVES: We aimed to investigate the link between rosacea and enteral microbiota.
METHODS: A cross-sectional study was performed in a sample of Korean women who participated in a health checkup program at the Kangbuk Samsung Hospital Health Screening Center between 23 June 2014 and 5 September 2014. The gut microbiome was evaluated by 16S rRNA gene and metagenome sequence analyses.
RESULTS: A total of 12 rosacea patients and 251 controls were enrolled. We identified links between rosacea and several changes in gut microbiota: reduced abundance of Peptococcaceae family unknown genus, Methanobrevibacter (genus), Slackia (genus), Coprobacillus (genus), Citrobacter (genus), and Desulfovibrio (genus), and increased abundance of Acidaminococcus (genus), Megasphaera (genus), and Lactobacillales order unknown family unknown genus.
CONCLUSIONS: A link between rosacea and enteral microbiota was observed in this metagenomic study. A large and elaborate study is needed to confirm these findings and to elucidate the mechanisms involved. This article is protected by copyright. All rights reserved.

PMID: 28636759 [PubMed - as supplied by publisher]

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