Use of Oral Isotretinoin in the Management of Rosacea

[Guide]

In this article, the authors discuss the use of oral isotretinoin in the management of rosacea, exploring dosage, comparable efficacy, safety, and cost.

J Clin Aesthet Dermatol. 2011 Sep; 4(9): 54–61.
PMCID: PMC3175801
Use of Oral Isotretinoin in the Management of Rosacea
Hyunhee Park, DO and James Q. Del Rosso, DO, FAOCD
 

[Guide]

In this study, we aimed to determine if low doses of isotretinoin were effective in patients with treatment-resistant rosacea.

Efficacy of Low-Dose Isotretinoin in Patients With Treatment-Resistant Rosacea
(Arch Dermatol. 1998;134:884-885) 

This report of cases describes the safe and successful use of therapeutic-dose oral isotretinoin in 3 patients with a history of pseudotumor cerebri. Drugs common in the treatment of acne vulgaris, such as minocycline and isotretinoin, have been reported in association with pseudotumor cerebri (PTC), which can lead to severe, irreversible symptoms, including vision loss. There is a paucity of data on isotretinoin use in patients with prior PTC.

Safe Use of Therapeutic-Dose Oral Isotretinoin in Patients With a History of Pseudotumor Cerebri
JAMA Dermatol.2015 Nov 18. doi: 10.1001/jamadermatol.2015.3447. [Epub ahead of print]]
Suzanne J. Tintle, MD, MPH; Julie C. Harper, MD; Guy F.Webster, MD, PhD; Grace K. Kim, DO; Diane M. Thiboutot,MD;

[Guide]

"Retinoids have the potential to cause varying degrees of myositis and their rapid identification could prevent major complications." Source