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Ivermectin May Cross the Blood Brain Barrier in High Doses

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On Wikipedia, under Side Effects, it states, "Since drugs that inhibit CYP3A4 enzymes often also inhibit P-glycoprotein transport, the risk of increased absorption past the blood-brain barrier exists when ivermectin is administered along with other CYP3A4 inhibitors. These drugs include statins, HIV protease inhibitors, many calcium channel blockers, and glucocorticoids such as dexamethasone, lidocaine, and the benzodiazepines."

  • Goodman and Gilman's Pharmacological Basis of Therapeutics, 11th edition, pages 122, 1084–1087.*

Clonazepam is a tranquilizer of the benzodiazepine class. Wikipedia
"Clonazepam". The American Society of Health-System Pharmacists. Archived from the original on 2015-09-05. Retrieved Aug 15, 2015.*

Under Pharmacokinetics, it states, [Ivermectin] does not readily cross the blood–brain barrier of mammals due to the presence of P-glycoprotein,[34] (the MDR1 gene mutation affects function of this protein). Crossing may still become significant if ivermectin is given at high doses (in which case, brain levels peak 2–5 hr after administration). In contrast to mammals, ivermectin can cross the blood–brain barrier in tortoises, often with fatal consequences.
[34] Borst P, Schinkel AH (June 1996). "What have we learnt thus far from mice with disrupted P-glycoprotein genes?". European Journal of Cancer. 32 (6): 985–990. doi:10.1016/0959-8049(96)00063-9. *

This thread at RF discusses this and a few report side effects from taking oral ivermectin. 

*Wikipedia citations

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