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Insights into the Role of ER Stress in Skin Function and Associated Diseases.

FEBS J. 2018 Dec 26;:

Authors: Park K, Lee SE, Shin KO, Uchida Y

Abstract
Endoplasmic reticulum (ER) stress is a mechanism that allows to protect normal cellular functions in response to both internal perturbations, such as accumulation of unfolded proteins, and external perturbations, for example redox stress, UVB irradiation, and infection. A hallmark of ER stress is the accumulation of misfolded and unfolded proteins. Physiological levels of ER stress trigger the unfolded protein response (UPR) which is required to restore normal ER functions. However, the UPR can also initiate a cell death program/apoptosis pathway in response to excessive or persistent ER stress. Recently, it has become evident that chronic ER stress occurs in several diseases, including skin diseases like Darier's disease, rosacea, vitiligo, and melanoma; furthermore, it is suggested that ER stress is directly involved in the pathogenesis of these disorders. Here, we review the role of ER stress in skin function, and discuss its significance in skin diseases. This article is protected by copyright. All rights reserved.

PMID: 30586218 [PubMed - as supplied by publisher]

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