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Nuclear Factor Kappa-B is Enriched in Eyelid Specimens of Rosacea: Implications for Pathogenesis and Therapy.

Am J Ophthalmol. 2019 Jan 28;:

Authors: Wladis EJ, Lau KW, Adam AP

Abstract
PURPOSE: To assess the role of nuclear factor kappa-B (NFKB) in cutaneous specimens of rosacea and unaffected tissue METHODS: Immunohistochemical staining was performed for the activated, phosphorylated variant of NFKB (pNFKB) in eyelid specimens of rosacea (n = 12) and normal, healthy tissue (n = 12). The numbers of positively-staining cells/40x microscopic field were counted across five consecutive fields. Additionally, quantitative western blotting was carried out for pNFKB and NFKB in specimens of rosacea (n = 15) and normal controls (n = 14). Statistical comparisons were performed via a dedicated software package.
RESULTS: The mean number of cells/40x microscopic field which stained positively for pNFKB was 18.4 for control patients (standard deviation = 15.3 cells) and 39.3 (standard deviation = 16.9) for rosacea patients, and the difference between the two groups was statistically significant (p = 0.0024). On western blotting, the mean ratios of pNFKB:NFKB for control and rosacea patients measured 0.58 (standard deviation = 0.81) and 3.11 (standard deviation = 3.53), respectively. The two groups were statistically significantly different (p = 0.0002).
CONCLUSIONS: The activated form of NFKB is enriched in rosacea, indicating a role for this pathway in the pathogenesis of this disease. Interference with NFKB signaling may represent a novel therapy for rosacea as clinical agents become available.

PMID: 30703356 [PubMed - as supplied by publisher]

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