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What is Rosacea Rebound?


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Rebound according to Medicine.net is "The production of increased negative symptoms when the effect of a drug has passed or the patient no longer responds to the drug. If a drug produces a rebound effect, the condition it was used to treat may come back even stronger when the drug is discontinued or loses effectiveness."  This can happen with any drug, but with rosacea the reports of rebound most often are with Mirvaso (Brimonidine) and to a lesser extent with Rhofade (Oxymetazoline Hydrochloride).

The RRDi began collecting negative anecdotal reports of Mirvaso Rebound and stopped at 242. 

Here are the positive anecdotal reports

Rhofade has less negative reports than Mirvaso. 

Both of these drugs are vasoconstrictors. You should be aware of this side effect or risk associated with these two drugs. 

However, it has been reported that those who use antibiotics for rosacea long term find that their rosacea returns rather quickly and is worse when antibiotic treatment is stopped, which is also a type of rebound.  

Rebound vs Allergic Reaction

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