Crotamiton for Demodectic Rosacea

[Guide]

Crotamiton is used mainly to treat scabies which is caused by the Sarcoptes scabiei mite and there are a few articles showing Crotamiton improves rosacea. If you are using crotamiton or know of any other articles like the ones below, please post in this thread. That is what volunteering is all about. Share your rosacea knowledge with other rosaceans. 

"After clinical manifestations, the mites may be temporarily eradicated with topical insecticides, especially crotamiton cream, permethrin cream, and also with topical or systemic metronidazole. In severe cases, such as those with HIV infection, oral ivermectin may be recommended." [1]

"When Demodex concentration is higher than 5/cm(2) we use topical crotamiton 10% or metronidazole." [2]

"The skin lesions resolved after treatment including systemic metronidazole, topical metronidazole, crotamiton, or gamma benzene hexachloride." [3]

"Patients with these skin conditions markedly improved with the use of topical crotamiton twice daily, regardless of results from a KOH test for the presence of Demodex mites. Crotamiton also possesses antipruritic properties, which may be helpful in cases associated with pruritis. Based on these findings, we recommend the use of topical crotamiton twice daily in patients with a chronic history of, or who present with, facial erythema, dryness, scaling, and roughness with or without papules/pustules." [4]

"A random sample of 16 female patients suffering from papulopustular rosacea (PPR) as well as (16) normal female healthy subjects as control group were adopted in this study to assess of Demodex folliculorum pathogenesis. It was done through determination of mite density using a standard skin surface biopsy 10.5 cm2 from different designated 6 areas on the face, and scanning electron microscopic study (SEM) as well as total IgE estimation. A trial of treatment using Crotamiton 10% cream with special program was also attempted. All subjects ranged between 35-55 years old. All patients with rosacea and 15 of the control group i.e. 75.93% were found to harbour mites. The mean mite counts by site distribution were 28.6 & 6.9 on the cheeks, followed by 14.5 & 3.0 on the forehead and lastly 6.8 & 0.8 on the chin in PPR and control groups respectively. The total mean mite count in patients was 49.9 initially and 7.9 after treatment. In the control group it was 10.7 & 10.6 respectively. The mean total IgE was 169.4 & 168.4 and 96.3 & 98.4 in PPR and control groups respectively Light and scanning electron microscopy revealed that all mites were pointing in one direction. Some of them were containing bacteria inside their gut and on their skin. After treatment 3 cases (18.75%) were completely cured, 10 cases (62.5%) gave moderate response while 3 cases (18.75) have no response. In conclusion, this study supports the pathogenic role of D. folliculorum in rosacea." [5]

"Crotamiton is marketed under the trade names Eurax, which is manufactured by Ranbaxy Laboratories in the United States, and GlaxoSmithKline in the United Kingdom, and Euracin, which is manufactured by Green Cross in South Korea. In Germany, it is marketed under the brand name Crotamitex. In India, it is sold as Eurax by Ranbaxy Laboratories." [6]

Crotamiton is included in with the Anti-parasitic Prescription Agents used to treat rosacea. 

Topical topical benzyl benzoate (BB) (+crotamiton) treatment for rosacea. 

End Notes

[1] Indian J Dermatol. 2014 Jan-Feb; 59(1): 60–66.
doi:  10.4103/0019-5154.123498
PMCID: PMC3884930
Human Demodex Mite: The Versatile Mite of Dermatological Importance
Parvaiz Anwar Rather and Iffat Hassan

[2] Ann Dermatol Venereol. 2011 Nov;138 Suppl 3:S211-4
Treatment of rosacea.
Parodi A, Drago F, Paolino S, Cozzani E, Gallo R

[3] J Am Acad Dermatol. 2009 Mar;60(3):453-62
Demodicosis: A clinicopathological study.
Hsu CK, Hsu MM, Lee JY

[4] J Clin Aesthet Dermatol. 2009 January; 2(1): 20–25.
Demodex Dermatitis, A Retrospective Analysis of Clinical Diagnosis and Successful Treatment with Topical Crotamiton
Joseph B. Bikowski and James Q. Del Rosso

[5] J Egypt Soc Parasitol. 1997 Apr;27(1):183-95.
 A study on Demodex folliculorum in rosacea.
Abd-El-Al AM, Bayoumy AM, Abou Salem EA.

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