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Non-invasive objective skin measurement methods for rosacea assessment: a systematic review.

Br J Dermatol. 2019 May 23;:

Authors: Logger JGM, de Vries FMC, van Erp PEJ, de Jong EMGJ, Peppelman M, Driessen RJB

Abstract
BACKGROUND: Rosacea assessment and therapy monitoring can be challenging to standardize, as most clinical evaluation systems are prone to interobserver variability and not always validated. Objective, reliable and preferably non-invasive measurement tools are therefore needed.
OBJECTIVES: To give insight into available non-invasive imaging techniques and biophysical methods in rosacea by performing a systematic review.
METHODS: PubMed, EMBASE, Cochrane and Web of Science databases were searched until 1 September 2018 in accordance with PRISMA guidelines, identifying studies providing original data about objective non-invasive imaging and/or biophysical skin measurement techniques for diagnosis, assessing severity or therapy monitoring of adult patients with cutaneous facial rosacea. Risk of bias of included articles was assessed with the Cochrane Risk of Bias tool, Newcastle Ottawa Scale and Quality in Prognosis Studies tool.
RESULTS: A total of 78 studies was included, describing 14 imaging and biophysical methods. Widespread information about (sub)surface cutaneous morphology and functionality was obtained. Methodological study quality was relatively low and interstudy outcome variability was large. Several tools show promising value in research settings; for treatment follow-up, Demodex mites are countable with reflectance confocal microscopy, spectrometry can quantify erythema, and rosacea severity could be objectified with skin hydration and transepidermal water loss measurements.
CONCLUSIONS: This systematic review describes the spectrum of non-invasive imaging and biophysical methods in rosacea assessment, giving multifaceted information about structure and properties of rosacea skin, especially useful for research purposes. Larger studies with good methodological quality are needed to create validated protocols for further implementation into research. This article is protected by copyright. All rights reserved.

PMID: 31120136 [PubMed - as supplied by publisher]

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