rss Posted January 23, 2008 Report Share Posted January 23, 2008 Related Articles [Cathelicidin LL-37 : A central factor in the pathogenesis of inflammatory dermatoses?] Hautarzt. 2007 Dec 23; Authors: Schauber J, Ruzicka T, Rupec RA Keratinocytes produce and secrete antimicrobial peptides which function as endogenous antibiotics and as signaling molecules within the cutaneous innate immune system. Recent studies demonstrate that the antimicrobial peptide cathelicidin LL-37 plays an important role in the pathogenesis of atopic eczema, rosacea and psoriasis. Whereas skin in atopic eczema shows decreased cathelicidin expression which leads to increased susceptibility to superinfection in those patients, overabundant expression of cathelicidin peptide fragments causes inflammation in rosacea. Finally, in psoriasis cathelicidin peptide binds to self DNA which triggers an autoimmune response. These studies demonstrate the role of cathelicidin as a central factor in the pathogenesis of cutaneous inflammation. Therapies targeting cathelicidin expression and function could lead to new treatments for these diseases. PMID: 18209993 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.f...p;dopt=Abstract = URL to article Link to comment Share on other sites More sharing options...
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