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Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: A 8-week, double-blinded, randomized, controlled trial.

J Dermatolog Treat. 2019 Aug 19;:1-16

Authors: Yang JH, Moon J, Yoon JY, Kim JW, Choi S, Cho SI, Hwang EJ, Suh DH

Abstract
Background: Herbal extracts with fewer adverse effects can be an alternative to these drugs because they can target various molecular pathways of acne pathogenesis. Objectives: To evaluate the clinical efficacy of herbal extracts (mangosteen, Lithospermum officinale, Tribulus terrestris L., Houttuynia cordata Thunb) for the treatment of mild to moderate acne vulgaris Methods: 60 patients were randomized in a 1:1 ratio to receive blinded treatment with herbal extracts or vehicle for 8 weeks. Inflammatory and non-inflammatory acne lesion counts, Investigator's Global Assessment, patient's satisfaction and safety profiles were assessed. We also performed skin biopsy at baseline and week 8 to confirm immunological changes with immunohistochemistry staining. Results: By the end of the study period, both inflammatory and non-inflammatory acne lesion counts were significantly decreased in herbal extracts group (P < 0.05). In immunohistochemistry staining, expression of IL-1α, IL-8 and keratin 16 were significantly decreased in herbal extracts group compared to vehicle group from baseline to week 8. There was no serious adverse events in both groups. Conclusion: This herbal extracts can be a new therapeutic option for patients with mild to moderate acne vulgaris who are reluctant to use drugs.

PMID: 31424962 [PubMed - as supplied by publisher]

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