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Mast Cells and the Innate Immune System Disorder

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image courtesy of Wikimedia Commons

"Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea." 

Front Med (Lausanne). 2019;6:324
The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea.
Wang L, Wang YJ, Hao D, Wen X, Du D, He G, Jiang X

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Ball-and-stick model of cromolyn molecule gif image courtesy of Wikimedia Commons

"Cromolyn sodium or other MC stabilizers affect the release of histamine and other inflammatory mediators from MCs to ameliorate erythema in ETR. Drugs including brimonidine and BoNT can also reduce the recruitment of MCs and inhibit MC degranulation to improve inflammation associated with rosacea."

Front Med (Lausanne). 2019; 6: 324.
Published online 2020 Jan 28. doi: 10.3389/fmed.2019.00324
PMCID: PMC6997331
PMID: 32047752
The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
Lian Wang, Yu-Jia Wang, Dan Hao, Xiang Wen, Dan Du, Gu He, and Xian Jiang

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