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Mast Cells and the Innate Immune System Disorder


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image courtesy of Wikimedia Commons

"Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea." 

Front Med (Lausanne). 2019;6:324
The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea.
Wang L, Wang YJ, Hao D, Wen X, Du D, He G, Jiang X

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Ball-and-stick model of cromolyn molecule gif image courtesy of Wikimedia Commons

"Cromolyn sodium or other MC stabilizers affect the release of histamine and other inflammatory mediators from MCs to ameliorate erythema in ETR. Drugs including brimonidine and BoNT can also reduce the recruitment of MCs and inhibit MC degranulation to improve inflammation associated with rosacea."

Front Med (Lausanne). 2019; 6: 324.
Published online 2020 Jan 28. doi: 10.3389/fmed.2019.00324
PMCID: PMC6997331
PMID: 32047752
The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
Lian Wang, Yu-Jia Wang, Dan Hao, Xiang Wen, Dan Du, Gu He, and Xian Jiang

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One mast cell, Mas-related G protein-coupled receptor-X2 (MRGPRX2), has been found to be significant, and that "its inappropriate activation may cause pseudoallergy and likely contribute to the pathogenesis of rosacea, atopic dermatitis, allergic contact dermatitis, urticaria and mastocytosis."

"By contrast, MRGPRX2-specific antibodies and inhibitors could be utilized for the modulation of allergic and inflammatory diseases that are mediated via this receptor."

Multifaceted MRGPRX2: New Insight into the Role of Mast Cells in Health and Disease

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"One study showed that the number of mast cells was significantly higher in lesions than in clinically uninvolved skin in patients with papulopustular and erythematotelangiectatic rosacea, and there was a positive correlation between mast cell density and the duration of rosacea."

Dermatology Times, Dermatology Times, May 2020 (Vol. 41, No. 5), Volume 41, Issue 5
Mast cells may play key role in rosacea pathogenesis
Ilya Petrou. M.D.

image courtesy of Dermatology Times

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