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Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea.

Biomed Res Int. 2020;2020:9705950

Authors: Wang L, Lu R, Wang Y, Wang X, Hao D, Wen X, Li Y, Zeng M, Jiang X

Abstract
Rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide that adversely affects the health of patients and their quality of life. However, the molecular characterization of each rosacea subtype is still unclear. Furthermore, little is known about the role of long noncoding RNAs (lncRNAs) in the pathogenesis or regulatory processes of this disorder. In the current study, we established lncRNA-mRNA coexpression networks for three rosacea subtypes (erythematotelangiectatic, papulopustular, and phymatous) and performed their functional enrichment analyses using Gene Onotology, KEGG, GSEA, and WGCNA. Compared to the control group, 13 differentially expressed lncRNAs and 525 differentially expressed mRNAs were identified in the three rosacea subtypes. The differentially expressed genes identified were enriched in four signaling pathways and the GO terms found were associated with leukocyte migration. In addition, we found nine differentially expressed lncRNAs in all three rosacea subtype-related networks, including NEAT1 and HOTAIR, which may play important roles in the pathology of rosacea. Our study provided novel insights into lncRNA-mRNA coexpression networks to discover the molecular mechanisms involved in rosacea development that can be used as future targets of rosacea diagnosis, prevention, and treatment.

PMID: 32185228 [PubMed - in process]

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Full Article (if anyone can make heads or tails of this article it would be much appreciated if someone could translate this paper into layman's language) 

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In the abstract paragraph above it mentions 'NEAT1 and HOTAIR, which may play important roles in the pathology of rosacea.' If you look at the diagram above at the top of the post you can find NEAT1 near the center of the diagram in red and HOTAIR just below NEAT1 to the right in blue. That probably helped you out a lot, didn't it? Just trying to helpful.