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APOSEC for Rosacea Research


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"APOSEC is a substance obtained from white blood corpuscles." [1] It is a biologic drug in clinical trials used in heart attacks, strokes, spinal cord injuries and for healing wounds. A paper suggests that APOSEC may help treat contact dermatitis. [2] APOSEC has shown to "induce angiogenesis, vasodilation, exert anti-microbial effects, inhibit thrombus formation, enhance the release of neurotrophic factors, and much more". [3] Watch this white board animation that explains APOSEC:

Since APOSEC may inhibit inflammation [2], who would sponsor any research related to rosacea on this? Could 10K members of the RRDi each donate a dollar to offer a clinician a motive to investigate this subject?

APOSEC is listed as one of the Biologic Treatments for Rosacea

What is APOSEC? 
"Secretome of Apoptotic Peripheral Blood Cells (APOSEC)" [4]

Would you like to sponsor research into this independently as a group of rosacea patient advocates in solidarity?  If we could gather 10K members into the RRDi and we all agreed to sponsor research into APOSEC for rosacea and each member donated one US$ dollar we could offer this to a clinician to investigate. At the very least, can you find the reply button in this post and comment on this subject? 

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There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  

End Notes

[1] Biologic drug APOSEC offers possible new treatments for dermal wounds, Medical University of Vienna, Science Daily

[2] Laggner, M., et al. (2020) Therapeutic potential of lipids obtained from γ-irradiated PBMCs in dendritic cell mediated skin inflammation. EBioMedicine. doi.org/10.1016/j.ebiom.2020.102774.

]3] Explain Secretome APOSEC, Focus Wound Healing, The Healing Power from Within, aposcience

[4] "Cell culture supernatants derived from irradiated apoptotic peripheral blood mononuclear cells (APOSEC)..." 
Basic Res Cardiol. 2011 Nov;106(6):1283-97.  doi: 10.1007/s00395-011-0224-6. Epub 2011 Sep 28.
Secretome of Apoptotic Peripheral Blood Cells (APOSEC) Confers Cytoprotection to Cardiomyocytes and Inhibits Tissue Remodelling After Acute Myocardial Infarction: A Preclinical Study
Michael Lichtenauer, Michael Mildner, Konrad Hoetzenecker, Matthias Zimmermann, Bruno Karl Podesser, Wolfgang Sipos, Ervin Berényi, Martin Dworschak, Erwin Tschachler, Mariann Gyöngyösi, Hendrik Jan Ankersmit

"paracrine factors secreted from apoptotic peripheral blood mononuclear cells (APOSEC)"

Basic Res Cardiol. 2012 Sep; 107(5): 292.
Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation
K. Hoetzenecker, A. Assinger, M. Lichtenauer, M. Mildner, T. Schweiger, P. Starlinger, A. Jakab, E. Berényi, N. Pavo, M. Zimmermann, C. Gabriel, C. Plass, M. Gyöngyösi, I. Volf, H. J. Ankersmit

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