Anti-Flushing Drugs

[Guide]

There are a number of drugs used by physicians as anti-flushing or as antihypertensive agents such as:

Antihistamines, Clonidine, Epinephrine, Lanreotide, Megestrol acetate, Monoxidine, Propranolol (Inderal), Sandostatin LAR, Nadadol, Rilmenidine, and Veralipride.

Ketamine 0.5% and Amitriptyline 1% has been reported in at least one case. 

Beta Blockers Used for Rosacea
Propranolol (Inderal) has been used for the treatment of persistent flushing in rosaceans. 

"Oral β-blockers could be an effective treatment option for rosacea patients with facial erythema and flushing that does not respond to conventional therapy." [1]

Alpha Blocker Used for Rosacea
Carvedilol (brand name Coreg) has also been used for treating Refractory Facial Flushing and Persistent Erythema of Rosacea. [2]

”Carvedilol is effective against rosacea, with inhibition of macrophage TLR2 expression as a novel anti-inflammatory mechanism.” [3]

Antidepressants
laser_cat [post no 2] reports using mirtazapine, effexor, and cymbalta. 

Other Treatments
For a comprehensive list of anti-flushing drugs (prescription and non prescription) click here. 

Discuss with your physician whether any of these drugs may help you.

Prescription and Non Prescription Flushing Avoidance

Blushing & Flushing Triggers

Anecdotal Reports

Thread started by Geoff1

SSRI - Worse before better?

How can I control flushing during sleep?

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End Notes

[1] Symptomatic treatment of idiopathic and rosacea-associated cutaneous flushing with propranolol
Helen Craige MD and Jack B. Cohen DO; SSRI - How can I control flushing during sleep?
Journal of the American Academy of Dermatology, Volume 53, Issue 5, November 2005, Pages 881-884.

J Am Acad Dermatol. 2020 Apr 29;:
Use of beta-blockers for rosacea-associated facial erythema and flushing: a systematic review and update on proposed mode of action.
Logger JGM, Olydam JI, Driessen RJB

[2] Carvedilol for the Treatment of Refractory Facial Flushing and Persistent Erythema of Rosacea.
Hsu CC, Lee JY.
Arch Dermatol. 2011 Jul 18.

[3] A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages

More info on flushing click here.