Guide

A topical nanocrystal Azelaic acid (AZA)-loaded hydrogels composed of Pluronic® F127 and hyaluronic acid mixture that are able to deliver AZA into the stratum corneum and deeper skin layers was considered in a study and we await further outcome of this research. For More Information

Intense pulsed light therapy (IPL ) along with a topical skin care regimen "produced a significant improvement in overall facial redness in patients with rosacea. Longer-term treatment with TSCR may produce continued improvement." For more information

Warning Concerning Brands of Horse Paste/Gel There are a number of horse paste/gel brands that also contain praziquentel (PZQ), an anthelmintic, which Wikipedia reports "is a medication used to treat a number of types of parasitic worm infections." Some brands are Pfizer Equimax Horse Wormer, Merial Zimecterin Gold, Bimeda Equimax and others. Praziquantel as far as we know has never been used to treat rosacea. Another horse paste, UltraCruz Equine Bio-Absorb Paste contains dioctahedral smectite (dio) which is used to treat acute diarrhoea. There may be other horse pastes that contain other active ingredients that you should carefully read the label on the horse paste and know what you are buying. Using treatments for horses or other animals which have not been FDA approved for humans may have some serious risks. The horse paste that everyone is reporting using is horse paste that only contains 1.87% ivermectin as the active ingredient. Read the label of the brand you are buying and if the active ingredient includes ivermectin and ANYTHING else, you may be in serious health risk applying this topically. Stick to the brands that ONLY have 1.87% ivermectin as the active ingredient. Always check with your physician before using ivermectin for your rosacea.

A study on 54 patients who met eligibility criteria with azelaic acid reports, "The biggest concern was cost (11.1%), with a mean importance score (IS) on a 10-point scale of 9.3." Other than this the report concludes, "Patient-reported side effects were rare. Minor patient-reported side effects and concerns do not appear to affect rosacea-related QoL and medication satisfaction. Compared to a previously conducted study of similar design with patients using metronidazole gel and metronidazole cream, more patients in the current study reported no concerns with their treatment, while the number of patients reporting no side effects, as well as mean SATMED-Q and DLQI scores, were similar." For more information • Now there is a low cost generic

image courtesy Wikimedia Commons The Russian Ministry of Health conducted a detailed study of demodex mites and rosacea on 212 men and women which is illuminating and confirms the effectiveness of using 1% ivermectin in treating rosacea is just as effective as using metronidazole combined therapy. Further, some new information about detecting a demodex mite density count is revealed that is significant news. While the paper is difficult to read, probably due to the translation, here are some of the jewels found in the report: (1) Light Microscopy Skin Scraping Not Reliable According to the report, if you use a skin scraping with a light microscope, there may be no reliable data on demodex density counts, which says, "The severity of the condition does not depend on the quantitative load of the mites in the scrape." The report states that "in the light microscopy of scrapes of Demodex mites in the number of 5 individuals per 1 cm2, only 6 healthy persons (n=6; 2.8%); in the remaining 66 healthy people (31.2%), the light microscopy of the scrapes was negative." "As a result of the study, we found that it is difficult to detect the mite by light microscopy of scrape per 1 cm2 of skin." However when using a 'Confocal laser scanning in vivo microscopy', there is a significantly more reliable data to count on, which this same report concludes, "Confocal laser scanning in vivo microscopy is an effective diagnostic method to detect Demodex mites that does not require preliminary preparation for analysis and allows detecting Demodex mites at the level of the spiky epidermis layer, which is not accessible for scarification, to identify the species belonging to the size of Demodex mites (from 100 up to 200 μm - Demodex brevis, 200 to 400 μm – Demodex folliculorum)." "Comparing the results obtained by light microscopy and confocal laser scanning in vivo microscopy in patients with rosacea and healthy people, in more cases Demodex mites are detected by confocal laser scanning in vivo microscopy, whereas scrape in these patients were negative." (2) The report confirms the size and movement of demodex "Using a confocal laser scanning in vivo microscope allowed determining the average size of Demodex mites. When determining the size of mites from 100 to 200 μm, it was believed that in this case Demodex brevis was observed, while the average length of the mite was 125 μm; from 200 to 400 μm – Demodex folliculorum with an average length of 293 μm. The average size of the width of Demodex mites was 24 μm." More information on the size of demodex. "In the examination of healthy people by light microscopy, Demodex mites were detected in 6 cases (2.8%). Given the ability of the mites to move over the surface of the skin at a speed of 8-16 mm/h, as well as random selection of the study site, this fact does not prove the absence of mites." The method of scattered light intensity (SLI) is used as a new quantitative method of evaluating the viability of Demodex mites. (3) Topical 1% Ivermectin Just as Effective as Metronidazole "Antiparasitic drug ivermectin, in the form of an external form (cream), at a concentration of 1% (1 time per day, the general course of 30 days) has a high therapeutic efficacy in patients with associated with Demodex mites (in 93.3% of cases). The effectiveness of external therapy with a drug containing 1% ivermectin (course of 30 days) is comparable to the combined treatment with the systemic drug metronidazole 250 mg per os 2 times a day and the external application of 1% metronidazole (gel) 1 time per day for 30 days." "Thus, clinical observations demonstrated a lack of superiority in combined antiparasitic therapy using a systemic drug compared to external therapy using a preparation containing 1% ivertmectin as a cream, as confirmed by statistical analysis. Stein et al. showed that after 12 weeks of ivermectin treatment, the skin of patients was defined as clean or almost clean. There was a significant reduction in the percentage of inflammatory lesions in the ivermectin treatment group. The results of the study showed that 1% ivermectin is an effective and safe treatment for inflammatory lesions in patients with rosacea." (4) No Demodex Mites Detected in Some Patients This paper reveals that in some humans there are no demodex detected. The report states, "the fact that in 55-100% of cases, mites are detected, both in patients with face dermatosis and with patients having no clinical signs of dermatological illnesses......II group is a comparison group, which was composed of patients with a diagnosis of rosacea with no Demodex mites. In Group II patients, two methods of study of Demodex mites were not found." What this means is the second comparison group demodex mites were not detected by two methods, light microscope by skin scraping and Confocal laser scanning in vivo microscopy. The study concluded that those in group two had no demodex mites. If this is true, then this is illuminating and definitely news since most literature says demodex mites are on all humans except new born babies. "In 80 patients with rosacea (37.8%) with Demodex mites were detected in an amount of less than 5 individuals per 1 cm2 or were absent altogether with a developed clinical picture of the condition." However, because of the ability of the mites to move, the report adds this caution: "In the examination of healthy people by light microscopy, Demodex mites were detected in 6 cases (2.8%). Given the ability of the mites to move over the surface of the skin at a speed of 8-16 mm/h, as well as random selection of the study site, this fact does not prove the absence of mites." (5) Role of Demodex on Humans "Demodex folliculorum shows signs of parasitism, while Demodex folliculorum brevis is a saprophyte." Most papers state that the role of demodex is not known. This is illuminating and definitely news. (6) Demodex Mites are Significantly Higher in Rosacea "Our findings confirm the hypothesis of Turgut Erdemir et al., that the Demodex mites affect the severity of the disease and contribute to the progression of the pathological process. In addition, the authors have proved that the density of mites increases depending on the severity of the disease." "The detection of Demodex mites is not only statistically more significant in patients with rosacea than in the rest of the population, but also as can be seen from the Table 2, Demodex mites were more often found in patients with more severe clinical forms of rosacea (pustulous, infiltrative- productive forms)." (7) Demodex brevis not as significant as Demodex Folliculorum "In patients with severe manifestations of the condition (pustulous and infiltrative- productive forms of rosacea), the species of the mites Demodex folliculorum (P<0.01) is more often detected. Demodex brevis is found in mild forms of the condition and in healthy people, without showing signs of parasitism." "When Demodex brevis is found, given its weak possibility of parasitism, treatment with antiparasitic drugs is not indicated." (8) After 30 days of Ivermectin Treatment there is an INCREASE of demodex mites "Patients enrolled in subgroup A received only external therapy with a drug containing 1% ivermectin in the form of a cream 1 time per day for 30 days. Patients enrolled in subgroup B received a drug containing 250 mg of metronidazole systemically 2 times a day, externally 1% metronidazole in the form of a gel 1 time per day for 30 days. A repeat visit of the patients took place after 30 days of continuous therapy. Subjectively, treatment regimens of patients were well tolerated, no side effects were noted, no patient was excluded from the study. When comparing the efficacy of the therapy, it was found that statistically significantly more Demodex mites were found after treatment with confocal laser scanning in vivo microscopy (P≤0.05) (Table 7)." The above is significant news. However, the patients nevertheless improved their rosacea in 30 days and the report concluded: "Analysis of the clinical picture showed a positive dynamics of therapy, which manifested itself in a significant decrease in the number of morphological elements characterizing the severity of inflammation (P≤0.05). The effectiveness of the therapy was confirmed by a reduction in subjective complaints of patients after the treatment, and patients who received only external therapy had no complaints of a feeling of lusters of skin and the appearance of greasy lusters, which is an additional advantage." You can read the entire Russian paper yourself here: Dermatol Reports. 2019 Jan 23; 11(1): 7675.Clinical picture, diagnosis and treatment of rosacea, complicated by Demodex mitesAlexey Kubanov, Yuliya Gallyamova, and Anzhela Kravchenko Etcetera Demodectic Rosacea (Variant) Demodex Update

The gold standard treatment for rosacea includes Soolantra (1% ivermectin) along with Oracea. Learn more.

Sol-Gel Technologies LTD is continuing its clinical trial with its generic ivermectin cream and has also released information on Epsolay for papulopustular rosacea, which is the first micro-encapsulated single active benzoyl peroxide (5%) prescription drug. For more information or download here: 0001178913-19-000060.pdf

Image courtesy of Galderma Itch Tracker is the first application in the world to measure and visualize itching. Nestlé Skin Health developed Itch Tracker using ResearchKit, which is an open source framework for medical research introduced by Apple. Nestlé Skin Health simultaneously launched Itch Tracker worldwide in April 2017. Wearing the Apple Watch on your arm, if you start the Itch Tracker app before you sleep, you can measure your scratching behavior during sleep and evaluate your itching objectively. Nestlé Skin Health developed Itch Tracker using ResearchKit, (an open source framework for medical research introduced by Apple), and released Itch Tracker worldwide as a clinical research project from April 2017 to May 2018. Nestlé Skin Health and Maruho Release Renewed Itch Measurement App ‘Itch Tracker’ for Apple Watch on July 5, Maruho Receives Exclusive Rights in Japan, Nestlé Skin Health, Media Newsroom, July 5, 2018

Galderma is partnering with top rosacea influencers to launch an empowering social media awareness movement during Rosacea Awareness Month (April): #RosaceaNoFilter. Led by popular online rosacea patient influencers, with the aim of continuing conversation about the true burden of rosacea, #RosaceaNoFilter will encourage patients to share their personal experiences of living with this common inflammatory skin disease, in the form of ‘selfie’ posts on social media, and to feel empowered to speak up about the beyond the visible impact. Galderma marks Rosacea Awareness Month with new insights into why some patients are self-treating and launches social media campaign to reinforce hidden impact of the disease, Nestlé Skin Health, Media Newsroom, April 8, 2019

We are collecting the Negative Reports (if anyone has a positive report, please post in this thread). There are positive reports and you can find them. It is a lot of work collecting positive or negative reports on this. Volunteering is what the RRDi is all about. Are you up to volunteering and collecting positive Rhofade reports? Our cursory investigation shows that there as many positive reports on Rhofade or possibly more than negative ones. Rhofade surely doesn't cure rosacea but it manages it if you have to appear good for a wedding or job interview, etc. For an example of a positive Rhofade report, consider this one: Alba [post no 23-] "Hi all I have been using the rhofade now for a year. i dont get rebound. It has helped about 30% i still flush but when i do i get over it quicker. also my skin used to hurt alot 90% when i flushed now doesnt hurt about 10% it hurts. I put it on my cheeks where i flush the most. At times if nose flushing i put it on there. I can use it on my nose on and off and dont get rebound. I tried Mirvaso and that i got bad rebound." --------------------------------------------------------------- anon [post no 6] "I stopped taking the Rhofade almost 4 months ago and I still flush pretty badly, but less often..." Aurora823 [post no 1] "I had a horrible reaction to Rhofade...." Katie Kelly, Rosacea (in English), Facebook, posts, "I had a really adverse reaction to Rhofade where I had intense flushing for about two weeks! I’m still experiencing some lingering redness. I only used it on a tiny spot twice. BUT your results may vary (my skin is extremely reactive and sensitive in general). Just be sure to spot test it before applying to your whole face!" Lea77 [post no 202] "I tried Rhofade for 4 days. If started burning my face so I stopped using it. I am now back to daily flares that feel like my face is on fire. With a 1 in 7 benefit to users I wish I had never tried it!!!" SR840910 [post no 227] "My doctor gave me Rhofade all nonshalantly. I began to use it once a day everyday for a few months. Well slowly I realized it was actually making my face more red. When I would not put it on, my face would be bright red, making me look ten times worse. I have completely stopped taking it now for about a month and my face is still very red." toomuchblush [post no 132] "Since stopping rhofade, my face has calmed down dramatically. I think rhofade will have many, many mixed reviews..." --------------------------------------------------------------- If you have had an experience with Rhofade and rosacea, wouldn't it be gracious on your part to post in this thread your experience so that other rosaceans might benefit? Reply to this TopicThere is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

A detailed report on cannabinoid signaling in the skin had this to say: "It has recently been shown that abuse of synthetic, hyperpotent cannabinoids (e.g., “Bonsai”, “fake weed”, “K2”, and “Jamaica”) can result in dermatological disorders, such as premature skin aging, hair loss and graying, or acne [88], indicating that cannabinoid signaling can profoundly influence skin biology." "Importantly, with respect to the efficiency of PEA, human clinical data are also available. Indeed, the PEA containing Physiogel® A.I. Cream was found to alleviate itch in 14 out of 22 patients suffering from prurigo, lichen simplex and other pruritic diseases. Importantly, the same formulation was found to be effective in alleviating erythema, excoriation, scaling, lichenification, dryness, as well as pruritus in AD patients (ATOPA study). However, another vehicle controlled, randomized clinical trial involving a total of 100 subjects suffering from pruritic dry skin (ClinicalTrials.gov ID: NCT00663364) found that a PEA containing lotion was not significantly superior in alleviating itch as compared to its emollient vehicle." PEA is Palmitamide MEA, a naturally occurring lipid compound that may act as an anti-oxidant and anti-irritant. Molecules. 2019 Mar; 24(5): 918. Published online 2019 Mar 6. doi: 10.3390/molecules24050918 Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System Kinga Fanni Tóth, Dorottya Ádám, Tamás Bíró, Attila Oláh

A sample of food-grade diatomaceous Earth Courtesy of Wikimedia Commons Diatomaceous earth - also known as D.E., diatomite, or kieselgur/kieselguhr – is a naturally occurring, soft, siliceous sedimentary rock that is easily crumbled into a fine white to off-white powder. Wikipedia Can it be used to treat demodectic rosacea? At least one person thinks so. This was posted initially at Facebook, diatomaceous earth mixed with honey improves rosacea. Without a doubt, since it was posted on Facebook, others will try this and we receive more reports since you can obtain food grade diatomaceous earth below and other mediums besides honey will be attempted and the results will be coming in. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

A number of anecdotal reports are using diaper rash treatments for rosacea. A typical example is Sarah Ann, Rosacea Tips and Support Group, Facebook, who posts "This is gonna sound kinda crazy but I’ve tried almost everything for my rosacea and finally a couple days ago I was got so desperate I tried using my daughters diaper rash cream lol. It must be the zinc in it but after 2 days of it my skin is better than ever! The brand is Weleda Baby. Any one else try anything like this? I’m amazed!" There are hundreds of others who report trying this treatment and using different brands and rave about it. Just search 'diaper rash treatment for rosacea.' Here are two more examples: A poster at the exclusive, private group, Rosacea Tips and Support Group, Facebook, posts, "This is the one I use [Honest Diaper Rash Cream] and recommend all the time in this group. It's for healing dehydrated skin. I also use it to calm irritation from a flare, and I apply a very thin layer under my makeup which keeps my skin soothed until washing it off. The opaque color also masks redness. I see so many people recommending this brand now so I must have started a revolution." Another poster at Rosacea Tips and Support Group, Facebook, posts, "I started Boudreaux's Butt Paste today. It has the highest Zinc content at 40%." If you try this treatment, please post your results in this thread.

"Quite simply, “groat” is the old Scottish word for the entire oat kernel minus the husk....Oat Groats are the whole grain - germ, bran, and endosperm - without having been rolled or steel cut!....Steel Cut Oats: Steel cut oats are whole oat groats that have been cut into two or three pieces. That's it." The Oatmeal Compendium There is discussion at RF started by butler that making a paste from oat groats or steel cut oats will clear your Rosacea/Seborrheic Dermatitis. It is a long thread but some report that it works, especially if you are into a natural treatment for your Rosacea/Seborrheic Dermatitis. Some prominent posters like Tom Busby. sejon, MrRed77, rednasstor are really into this. One method used to make the paste is to put the oats into a coffee grinder and add water to make the paste. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

Thanks for the tip Apurva. Finding a SUN BLOCK is not easy, however, I found one: You may find this sunscreen interesting even though you said sunscreens tend to dry your skin, probably one like this? The Neutrogena Hydro Boost may be better for your skin or the Neutrogena Clear Face Sunscreen? I tried to find 'sun block' at Amazon and I just get a list of sunscreens and only found that one. I will keep searching. The RRDi has collected a number of cosmetics to consider in your search by using our affiliate store.

Thanks Apurva Tathe for your posts.

Would fasting improve rosacea? One recent report says, "Another study performed by Smith et al. in 2008 has shown the beneficial impact of caloric restriction on acne vulgaris lesions. This was explained by decreased sebum production, which thereby counterbalances one of the main factors in the pathogenesis of acne vulgaris.....Despite such important practical implications, this topic has been neglected in the existing scholarly literature, when it deserves further research. High-quality randomized controlled trials (RCTs) should be conducted to systematically explore and compare different fasting protocols, including the use of vegetables and fruits for caloric and metabolic manipulations." [1] Wouldn't it be a novel idea to get 10K RRDi members together and each donate one dollar and offer $10K to one of our RRDi MAC members to conduct a clinical trial on this. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post. End Notes [1] Fasting and Its Impact on Skin Anatomy, Physiology, and Physiopathology: A Comprehensive Review of the Literature

A poster at the exclusive, private Facebook group, started a thread about using Ichthammol for her rosacea, and reported it worked for her. Ichthammol is Ammonium bituminosulfonate, "a product of natural origin obtained in the first step by dry distillation of sulfur-rich oil shale (bituminous schists)....has anti-inflammatory, bactericidal, and fungicidal properties. It is used to treat eczema, psoriasis, Acne rosacea and acne, and it decreases microorganisms in the area surrounding a skin condition. It is commonly used in 10% or 20% concentrate ointment, applied topically." Wikipedia "Materials made in China (Pinyin transcription: yushizhi and yushizhi ruangao) and offered outside China as Ichthammol or Ammonium Bituminosulfonate are not in line with the definition given for this substance in the United States Pharmacopoeia (USP) or European Pharmacopoeia (Ph.Eur)." Wikipedia Post your experience with ichthammol ointment in this thread. &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;iframe style="width:120px;height:240px;" marginwidth="0" marginheight="0" scrolling="no" frameborder="0" src="//ws-na.amazon-adsystem.com/widgets/q?ServiceVersion=20070822&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;OneJS=1&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;Operation=GetAdHtml&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;MarketPlace=US&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;source=ac&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;ref=tf_til&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;ad_type=product_link&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;tracking_id=rosaresedevei-20&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;marketplace=amazon&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;region=US&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;placement=B014MRR7NY&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;asins=B014MRR7NY&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;linkId=4269b7a89ac4cfe9d8f5173ec24d28e2&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;show_border=false&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;link_opens_in_new_window=false&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;price_color=333333&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;title_color=0066c0&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;bg_color=ffffff"&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; Reply to this TopicThere is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

Romeo Milea has since resigned from the board. Sent from my iPad using Tapatalk

mac5400 at Reddit, gives a tip to avoid flushing, of taking a supplement, Diamine oxidase (DAO), and writes, "I now take an OTC supplement called UmbrelluxDAO before i eat or drink. It contain the enzymes responsible for metabolizing histamine. And I barely flush anymore. The chronic rosiness on my cheeks has significantly reduced; more than any cream I've ever tried. In combination with a low histamine diet, i think i finally found the "cure" to my "rosacea." It's such a breakthrough for me. This supplement is life-changing." "Diamine oxidase (DAO), also known as histaminase, is an enzyme (EC 1.4.3.22) involved in the metabolism, oxidation, and inactivation of histamine and other polyamines such as putrescine or spermidine in animals." Wikipedia Added DAO to the list of anti-flushing treatments. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

Dimethicone in Soolantra Someone at Reddit points out an article published in the Tropical Medical Health by Hermann Feldmeier that concludes, "Dimeticones are a family of compounds with a physical mode of action, targeting an Achilles heel of ectoparasites." I found another article that state dimethicone is a pediculocide. I did find this article that says "dimethicone lotion is not an insecticide and instead kills lice by suffocation," which may explain it. Dimeticone redirects to Polydimethylsiloxane. Dimethicone redirects to Polydimethylsiloxane. The Wikipedia article on Polydimethylsiloxane says it is used in medicine "in over-the-counter drugs as an antifoaming agent and carminative" with no mention of it being used as an insecticide or kills parasites. "Perhaps dimethicone is an old fashioned treatment for head lice, because like you, I can't find a reliable reference for using it as a miticide or arachnicide or insecticide. With lice, sometimes treatments are called any of these 3 terms. "Mite" is an old-fashioned English word, "arachnid" is the scientific term, and "insect" is just plain wrong, for referring to head lice or demodex. Watch out too for chemical names, as there are silicones that are oil soluble, water soluble, and not soluble in either oil or water. And, I can't find the recommended concentration for treating head lice with dimethicone -- if, ,for example, it's 15%, that would be far too messy to be cosmetically acceptable for trying it on the face. From my personal point of view in formulating, I like only water soluble silicones, because some of them wash out easily with water, but still provide some "slip" (ease of combing hair, or detangling). The other silicones just sit there on the skin or on the hair, and don't do anything useful from an aesthetic point of view." Tom Busby, Post no 7, Rosacea Forum "Dimethicone doesn't have any biocidal properties. The mode of action on the treatment of headlice is to prevent the adhesion of lice and the louse eggs on to the hair shaft. Headlice produce a strongly adhesive mucus secretion to stick their eggs (nits) to hair. Dimethicone prevents this adhesion and also interferes with the 'foothold' that the adult lice have on the scalp. Dimethicone is not immediate acting and requires several days for its effect to be apparent. It requires thorough combing of the hair after use to remove loosened lice and nits." johnabetts, Post no 8, Rosacea Forum "Dimethicone was also the main ingredient (first in list) in the Dermalogica Close Shave Oil, no longer available. I have no signs of rosacea in my shaving area - only on the ears and nose, where clearly I didn't apply the shaving oil. The point with a shaving oil is, assuming you shave every day or two, it is very easy to fully cover the area on a very regular basis. I also thought Soolantra cream had good moisturising properties when I used it. Unfortunately it seemed to stop working on killing mites after a while, and I've had longer term success with Zhongzhou cream." antwantsclear, Post no 9, Rosacea Forum

image courtesy of WikiMedia Commons Just thought I would vent a little since, after all, I founded the RRDi, and no one hardly ever posts, even though there are over 1200+ members, and we know that many are viewing the posts since we have counters showing the number of views, so we know that rosacea sufferers are learning about rosacea from our website. So I posted about this a while back, Where Have All the Rosaceans Gone?, back in February 2018, which did elicit one reply from RedMage, which is much appreciated, and has as of this date 96 views, so the odds are 1 in 96 that someone will reply to this post. So I have been posting some at Reddit and Facebook to see what is going on, and am appalled at the lack of basic rosacea knowledge, and I have been trying to educate rosaceans and, got a disparaging post from a Reddit poster who I had commended for some good investigative reporting on finding that Soolantra isn't really using Cetaphil as its 'vehicle base' [1] and was told that "the Rosacea Research & Development Institute (RRDi) is a sham 'institute' operating from a PO Box that conducts no research or development, hasn't published a journal since 2010, and doesn't even publish its 990s like any reputable 501(c)(3) public charity would be expected to. You're not fooling anyone." That really made my day. Here I have devoted countless volunteer hours trying to make the RRDi a non profit rosacea patient advocacy organization and this certainly made me feel blue. It still boggles my mind that rosaceans continue to support and donate to the National Rosacea Society, which is the chief reason we formed the RRDi in 2004 (read this in case you haven't clue about this). Rosaceans actually prefer the NRS and how it spends its donations. Mind boggling to me. So just want you to know, that is the 96 that may view this post, that if some of you don't step up to the plate and start volunteering, posting and doing something as a member of the RRDi that this non profit organization for rosacea may indeed have to close. Then all you got is the NRS, the AARS, and the ARSC. It really is up to you. And I don't mean up to others, I mean up to you. Oh, you will still have your Facebook and Reddit rosacea groups which is what most rosaceans prefer so you will be in good company. Is that really what you prefer? Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post. End Notes [1] See end note [3] in this post

In Rosacea News, we have the post about this subject in detail for your information. Please post in this thread your experience using the horse paste, what brand you use, how often you are applying it, and other details and hopefully photos of before and after. Members may post their own blog, club or gallery. We have a poll about which brand you are using if you would please participate in this poll, it would be very much appreciated.

As mentioned earlier in this thread, one of the issues with using an oral horse paste TOPICALLY for rosacea sufferers is usually there is no inactive ingredient list to see what is actually in the paste or gel. However, one poster at Reddit found the list for one of the products, Eqvalan, which is listed for your convenience below: Eqvalan Oral Paste for Horses Ingredients: Ivermectin: 1.87% w/w. Titanium Dioxide (E171) 2.0% w/w. Hyprolose Hydrogenated Castor Oil Propylene Glycol Source Eqvalan_SPC_214477.pdf Link for the above: http://www.vmd.defra.gov.uk/productinformationdatabase/SPC_Documents/SPC_214477.DOC Eqvalan MSDS EqvalanMSDS.pdf Link for the above: https://www.statelinetack.com/ContentFiles/Associated_Content/EqvalanMSDS.pdf If anyone finds the ingredients in any other horse paste/gel please post in this thread.

These recommendations are from ElaineA and Tom Busby at RF: 20 Muleteam Borax powder is available in US grocery stores in the laundry aisle. Price locally for me is currently about $5.59 per box. Borax is used as a water softener for laundry. Try washing your washable clothes with some borax powder added to the wash load. Borax powder dissolves best in warm or hot water. For a cold wash, pre-disolving the borax powder in warm or hot water before adding to the wash, would be a good idea. Instructions on the box recommend adding 1/2 cup of borax powder per wash load. I don't know for sure that they can live for long on dry clothes, but they might - especially if there is enough oil or body lotion on the clothes or if the clothes are damp. I've read that they can live up to 54 hours on a wet towel. Wool has natural lanolin oil in it which may give them enough oil to survive when their human host is not available. The wool scarves are trickier. If you can wash these in cold water, diluting the borax powder first in hot water, allow it to cool enough, then add to the cold wash water for the scarf might be the best approach. Then as Tom said put the scarf in the sun to dry. Interesting that the Malessezia fungus is light sensitive. Demodex cannot be cultured in a lab (they die in an hour or two when removed from the host). They have such short lives, your clothes are not going to be a source of re-infestation of live demodex -- but as above though, the eggs should be washed off in soapy water. As far as I know, no one knows how the long the eggs can survive, so to be certain, you can add a tiny amount of tee tree oil to the wash-cycle of your washing machine or wash basin -- rinse the TTO off completely so it doesn't stain your clothes (especially silk or wool), and you shouldn't have to worry. Normal "good housekeeping" for washing your clothing is sufficient in my opinion. This is a variable idea though, as winter clothing worn next to the skin, like a scarf or gloves, will probably need more washing than most people would consider "normal." About every 2-3 weeks should be enough. The hood and collar of coat (assuming the coat can't be washed) is more problematic though, and you might douse the collar and cuffs in 91% isopropyl alcohol every 2-3 weeks, and let it air dry until there's no smell. Isopropanol dries extremely quickly in a dry, winter climate. Color-test isopropanol in an inconspicuous place to be sure it doesn't lift the dye, first. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.