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Guide

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  1. Just received the TEA Form 990 for 2019, which this non profit is not required to file Form 990 EZ for 2019 since donations were less than $50K (only received $21,578.00 in donations in 2019) and could have filed Form 990 N. 

    TEA spent $18K on 'printing, publications, postage, shipping and other expenses.' So no research grants were sponsored in 2019. No money spent on staff or 'conventions' for members. 

    Considering TEA has over 2000 members who donated $21K, this non profit gets high marks for what is being accomplished according to the mission statement and still has over $125K in the bank in net assets. 

    Read the Form 990 yourself. We could only wish that RRDi members would donate half as much as TEA members do.  

    TEA 990 . 2019.pdf

  2. UPDATE

    "The study concluded that treatment with hydroxychloroquine significantly reduces the death rate of COVID-19 patients, Zervos said. Of those treated with hydroxychloroquine alone, 13% of them died, compared to the 26.4% who died and were were not treated with the drug. There was an overall 18.1% in-hospital mortality rate and patients were over the age of 18, with a median age of 64."

    Hydroxychloroquine is effective in treating COVID-19, says Henry Ford Health System study, Andrew Mullin, MLive

  3. We are pleased to announce that members can now post REVIEWS in our affiliate store. Here is a screen shot of a review:

    sufurbutterreview.png

    In the screen shot above the review can be viewed if you click on the tab PRODUCT REVIEWS and MEMBERS can RESPOND TO THIS REVIEW. So if you find an item in our store and you have used the item and want to review it all you do is, (1) Find the item in the store, (2) login with your RRDi account (only requires registering with an email address), (3) Scroll down to the product information tab and next to this tab find the PRODUCT REVIEWS tab and click on it. (4} Find the WRITE A REVIEW black button and click on it (5) Write your review in the comment box

    rrditeeshirtwriteareview.png

  4. The controversy about hydroxychloroquine continues.

    "Not all researchers have given up on the drug, however, and recent developments show it is not yet dead as a potential weapon against COVID-19, especially as a preventative in people not yet exposed to the virus." 

    Hydroxychloroquine is not dead yet, Lisa Cavazuti, NBC News

    ---------------------------------------------------------------------------------------------------

    "Once praised as a miracle cure for covid-19, an antimalarial drug called hydroxychloroquine has rarely been out of the headlines since the start of the pandemic. It was hoped it might find a new use as a therapy in patients who are unwell with the novel coronavirus. But in recent weeks a scientific picture has emerged of a treatment that does not appear to be helping patients at all, and might even be causing harm.

    Whether it helps seems clear now: it doesn’t. When it comes to the harm, though, it turns out that the scientific literature may be misleading. On June 4th the Lancet, a respected medical journal, retracted a high-profile paper published only a month previously. This had suggested that hydroxychloroquine and its analogue, chloroquine, actually increased the death rate in hospitals when taken by those with covid-19. This led the World Health Organisation to halt its trials of the drug. It also caused considerable concern to patients and to those enrolled on other such trials."

    Hydroxychloroquine is embroiled in yet more controversy, The Economist

  5. "The U.S. Food and Drug Administration revoked its emergency authorization for hydroxychloroquine, a controversial malaria drug promoted by President Donald Trump for treating the coronavirus. The agency said in a letter the decision is based on new evidence that made it unreasonable to believe hydroxychloroquine and chloroquine "may be effective in diagnosing, treating or preventing" COVID-19, the illness caused by the virus."

    Hydroxychloroquine: FDA pulls emergency use of malaria drug touted by Trump to treat the coronavirus
    Adrianna Rodriguez
    USA TODAY

  6. "The U.S. Food and Drug Administration revoked its emergency authorization for hydroxychloroquine, a controversial malaria drug promoted by President Donald Trump for treating the coronavirus. The agency said in a letter the decision is based on new evidence that made it unreasonable to believe hydroxychloroquine and chloroquine "may be effective in diagnosing, treating or preventing" COVID-19, the illness caused by the virus."

    Hydroxychloroquine: FDA pulls emergency use of malaria drug touted by Trump to treat the coronavirus
    Adrianna Rodriguez
    USA TODAY
     

     

  7. "A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, interferon‐beta, and other potential drugs have been studied for COVID19 treatment. We reviewed the potential dermatological side‐effects of these drugs."

    Dermatol Ther. 2020 May 22 : e13476.doi: 10.1111/dth.13476 [Epub ahead of print]
    Cutaneous sıde‐effects of the potential COVID‐19 drugs
    Ümit Türsen, Belma Türsen, Torello Lotti 

    ==============================================

    "The US now has more hydroxychloroquine than it knows what to do with following a series of studies that concluded the drug is an ineffective and potentially dangerous treatment for COVID-19. The federal government, which started stockpiling the drug in March, now has 63 million surplus doses of the drug, donated by companies including Novartis, and another 2 million doses of chloroquine, the New York Times reports. Some 31 million doses from the Strategic National Stockpile were distributed before the FDA withdrew its emergency authorization of the drug to treat the coronavirus. President Trump championed the drug for months, hailing it as a possible "game-changer" and announcing that he was taking it himself."

    US Is Stuck With 63M Doses of Hydroxychloroquine, Rob Quinn, Newser

    =============================================

    With the recent news that oral hydroxycholoroquine is just as effective as oral doxycycline for rosacea, maybe we will be hearing more anecdotal reports of hydroxycholoroquine improving rosaceaA report published in the Journal of the American Academy of Dermatology reports that oral hydroxychloroquine is just as effective as oral doxycycline. [see post no 7 in this thread by scrolling down for the clinical paper source associated with this]

  8. Update

    "A massive study that raised health concerns over hydroxychloroquine, the anti-malaria drug touted by President Trump as a coronavirus treatment, is coming under scrutiny from scientists who are demanding to see the data behind it."

    Massive hydroxychloroquine study raising health concerns about the drug under scrutiny from scientists, Tal Axelrod, The Hill, MSN

    "After high-risk or moderate-risk exposure to Covid-19, hydroxychloroquine did not prevent illness compatible with Covid-19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure."

    N Engl J Med DOI: 10.1056/NEJMoa2016638
    A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
    David R. Boulware, M.D., M.P.H., Matthew F. Pullen, M.D., Ananta S. Bangdiwala, M.S., Katelyn A. Pastick, B.Sc., Sarah M. Lofgren, M.D., Elizabeth C. Okafor, B.Sc., Caleb P. Skipper, M.D., Alanna A. Nascene, B.A., Melanie R. Nicol, Pharm.D., Ph.D., Mahsa Abassi, D.O., M.P.H., Nicole W. Engen, M.S., Matthew P. Cheng, M.D., et al.

  9. Update

    "In this study, a high-dosage of CQ (12 g) given for 10 days concurrently with azithromycin and oseltamivir was not sufficiently safe to warrant continuation of that study group. Age was an important confounder and might be associated with the unfavorable outcomes. We recommend that similar dosages no longer be used for the treatment of severe COVID-19, especially because treatment based on older patients with previous cardiac diseases who are receiving concomitant cardiotoxic drugs should be the rule. No apparent benefit of CQ was seen regarding lethality in our patients so far. To better understand the role of CQ or HCQ in the treatment of COVID-19, we recommend the following next steps: (1) randomized clinical trials evaluating its role as a prophylactic drug and (2) randomized clinical trials evaluating its efficacy against the progression of COVID-19 when administered to patients with mild or moderate disease. Even if we fail to generate good evidence in time to control the current pandemic, the information will affect how we deal with coronavirus outbreaks in the future."

    JAMA Netw Open. 2020;3(4):e208857. doi:10.1001/jamanetworkopen.2020.8857
    Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) InfectionA Randomized Clinical Trial
    Mayla Gabriel, Silva Borba, MD; Fernando Fonseca Almeida Val, PhD, Vanderson Souza Sampaio, PhD

  10. William Beaumont Hospitals is sponsoring two treatments used for rosacea, Naltrezone and Ketamine, in a clinical trial to treat coronavirus. [1]

    Low Dose Naltrezone is used for rosacea in this post about flushing avoidance and in other prescriptions

    Ketamine 0.5% and Amitriptyline 1% in a Lipoderm cream used for Erythomelalgia has been reported anecdotally to improve rosacea in this post

    These two treatments above are included in a growing list of rosacea treatments considered to treat coronavirus.

    End Notes

    [1] Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19 (SINK COVID-19), NIH, Clinical Trials

  11. bilogics.jpg
    Biologics image - stock.adobe.com

    "Over the coming years, the growth in the biologics market is projected to be rapid, reaching US $580.5 billion (approximately €513.5 billion) by 2026." [1]

    What are the biologic treatments for rosacea? 

    First, what are we referring to? Biologic treatments are those derived from biological sources rather than from totally synthesized pharmaceuticals sources. [2] This post will include those that are biologic specifically for rosacea and those that might be considered helpful for rosacea but are not specifically for rosacea, instead these treatments might be used for rosacea or other diseases. The vast majority of treatments for rosacea are derived from synthesized pharmaceutical sources and are found in this category. If you know of any other biologic treatments for rosacea not listed below find the green reply button and be a RRDi volunteer!

    Biologic Treatments for Rosacea

    Aloe Vera

    Antibiotics 

    APOSEC

    Artemisinin

    Bees & Snails

    Botox

    Coconut Oil

    Cucumber [3]

    Diatomaceous Earth

    Honey

    Nonpathogenic E. coli strain Nissle 1917

    Probiotics

    Rose Hip Oil [4]

    Rose Petals

    Rose Water

    Secukinumab

    Stem Cells

    Reply to this Topic

    There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  

    End Notes

    [1] Rising to the Challenge of Biologic Drug Formulation, Felicity Thomas, Pharmaceutical Technology, Volume 43, Issue 3, pg 26–29

    [2] "A biopharmaceutical, also known as a biologic(al) medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines, blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living medicines used in cell therapy. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living cells or tissues. They (or their precursors or components) are isolated from living sources—human, animal, plant, fungal, or microbial." Wikipedia

    [3] “Cucumber was mentioned as early as 1649 as a treatment for facial redness in a text on herbal remedies by Nicholas Culpepper, an English botanist and physician, but cucumber has not been studied scientifically.” Natural Remedies for Rosacea?
    BY THE NEW YORK TIMES  JUNE 25, 2009 10:05 AM, Dr. Frank C. Powell 

    [4] Dry Skin (Xeroderma), Rose Hip Oil End Note 3

  12. In summary, this multinational, observational, real-world study of patients with COVID-19 requiring hospitalisation found that the use of a regimen containing hydroxychloroquine or chloroquine (with or without a macrolide) was associated with no evidence of benefit, but instead was associated with an increase in the risk of ventricular arrhythmias and a greater hazard for in-hospital death with COVID-19. These findings suggest that these drug regimens should not be used outside of clinical trials and urgent confirmation from randomised clinical trials is needed.

    The Lancet
    Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

    Prof Mandeep R Mehra, MD 
    Sapan S Desai, MD
    Prof Frank Ruschitzka, MD
    Amit N Patel, MD

  13. In summary, this multinational, observational, real-world study of patients with COVID-19 requiring hospitalisation found that the use of a regimen containing hydroxychloroquine or chloroquine (with or without a macrolide) was associated with no evidence of benefit, but instead was associated with an increase in the risk of ventricular arrhythmias and a greater hazard for in-hospital death with COVID-19. These findings suggest that these drug regimens should not be used outside of clinical trials and urgent confirmation from randomised clinical trials is needed.

    The Lancet
    Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

    Prof Mandeep R Mehra, MD 
    Sapan S Desai, MD
    Prof Frank Ruschitzka, MD
    Amit N Patel, MD

    Update: June 4, 2020

    Retraction: "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis"

  14. RRDi Tee Shirts

    We are happy to announce we have made an arrangement with Model Tees to have RRDi Tee shirts available for members with some slogans that we have come up with including the RRDi butterfly logo and in choices of eight colors! In the poll above we are asking you which slogan do you vote for since Model Tees has to have an order of at least 24 tee shirts before making them. Please vote above in the poll to let us know which one you like the best and logically then if more than 24 like a certain logo we can have Model Tees offer that slogan on their website and will make them in a batch order once all 24 have paid and ordered one.

    Want Your Own Slogan?

    If you want to add another slogan to the poll use our GUEST FORUM and recommend your own slogan, or  please contact us with your slogan, we could use your slogan and add it to the above list.  Or if you have the volunteer spirit why not find the reply button and post your slogan in this thread! All that is required is an email address to register and post in this thread. Your slogan might be added to the list above and others can vote on your slogan as the best one. All tee shirts come in eight colors and have the RRDi butterfly logo. The two beta version RRDi Model Tees has available for ordering are shown below. Here are the choices of color below: 
     eightcolors.png

    rrdiwarrior.thumb.png.1165f1ed469f16b895

    rrdiflare.thumb.png.bf5f378457fc1aa044fa

  15. 241px-Brittany_Snow_(26429768627)_(cropped)_(cropped).jpg

    An American actress, producer, director, and singer, Brittany Snow, has rosacea. [1]

    Reply to this Topic

    There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  

    Famous Rosaceans

    End notes

    [1] Brittany Snow Cleared Her Chronic Rosacea Using These 5 Products, Amanda Montell, Byrdie

    Image courtesy of Wikimedia Commons

  16. 129px-Dollar_symbol_gold_svg.png.96ce4c2

    If you appreciate all the data on rosacea that you see available on the RRDi website in your search for a way to control your rosacea and found this helpful and would like to keep this non profit organization for rosacea a viable and productive web resource, can you donate one dollar to keep the RRDi going?  We rely solely on donations. No one is getting paid or receives a salary. The RRDi staff are working pro bono as volunteers who care about rosacea sufferers. Note below what Margaret Mead was asked by a student that is related to what you can do for rosacea sufferers. Do you care about rosacea sufferers? If you have rosacea, you might have a bone in your body with a tinge of caring for others. 

    margaret_mead.jpg

    A 15,000 year old bone and the Fall 2013 issue of Reflections, Jeffrey Oak ’85 M.Div., ’96 Ph.D., Yale Divinity School

    RRDi Non Profit Organization 
    You may have your idea how a non profit organization for rosacea should be run and there are other non profits for you to choose giving your support. We would hope you appreciate how different the RRDi is run and that you approve of how it is run by donating one dollar to help keep the RRDi going. In May 2020 we have over 1400 plus members. If each member donated just one dollar it would be enough for our non profit to remain viable for about a year!  Just think of the power of one dollar with so many members. That is less than the cost of a cup of coffee.

    Reply to this Topic
    There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  

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