PubMed RSS Feed - -Successful Treatment of Granulomatous Rosacea by JAK Inhibitor Abrocitinib: A Case Report

"Trichoscopy is a method of hair and scalp evaluation and is used for diagnosing hair and scalp diseases. The method is based on dermoscopy." [1] "In many cases the combination of clinical examination and trichoscopy is sufficient for establishing the correct diagnosis....The most characteristic features of scalp rosacea are perifollicular scaling and arborizing vessels." [2] Why I like trichoscopy? Professor Lidia Rudnicka End Notes [1] Trichoscopy, Wikipedia [2] PubMed RSS Feed - -Differential diagnosis of red scalp. The importance of trichoscopy image courtesy of Wikipedia Commons

Clin Cosmet Investig Dermatol. 2023 Nov 20;16:3369-3374. doi: 10.2147/CCID.S440138. eCollection 2023. ABSTRACT Granulomatous rosacea (GR) is a rare inflammatory skin disease characterized by persistent, hard, yellow, brown, red, or flesh-colored papules, plaques, or nodules on the face. Limited data are available on patients treated for GR, with only case reports and case series published. Herein, we describe the case of a 53-year-old woman who presented to the hospital with persistent red to brown and pink patches on both cheeks accompanied by a burning sensation for one month. Histopathological examination of a cutaneous biopsy revealed granulomatous inflammation in focal areas. Both acid-fast and Periodic acid-Schiff staining were negative. The patient was diagnosed with GR based on her clinical presentation and laboratory test results. She was treated with abrocitinib, a JAK-1 inhibitor, for 20 weeks. This resulted in substantial improvement in her rash and the associated burning sensation. Subsequent follow-up visits indicated no adverse effects or relapses. Additionally, a literature review was conducted to compare with the current case, which concluded that abrocitinib is a viable treatment option for GR, exhibiting a relatively high safety profile with minimal side effects. PMID:38021428 | PMC:PMC10674708 | DOI:10.2147/CCID.S440138 {url} = URL to article

Clin Cosmet Investig Dermatol. 2023 Nov 18;16:3363-3368. doi: 10.2147/CCID.S441581. eCollection 2023. ABSTRACT An abnormal density of Demodex mites can trigger many skin disorders known as demodicosis. Clinical manifestations of demodicosis may resemble other skin diseases and can coexist with other skin disorders, resulting in underdiagnosis and a more challenging diagnosis. Here, we report three cases of demodicosis in acne vulgaris patients. These case series have discussed their clinical features along with optimal strategies for diagnosis and treatment. PMID:38021431 | PMC:PMC10664713 | DOI:10.2147/CCID.S441581 {url} = URL to article

Postepy Dermatol Alergol. 2023 Oct;40(5):642-646. doi: 10.5114/ada.2023.130523. Epub 2023 Aug 22. ABSTRACT INTRODUCTION: The relationship between rosacea and basal cell carcinoma (BCC) is still not known. Almost all reports questioning the relation between BCC and rosacea are focused on rhinophyma. AIM: To examine the possible connection of BCC and rosacea. MATERIAL AND METHODS: 110 patients with BCC located on the face treated surgically in the Dermatosurgery Unit in 2020-2021 were included in the study. A trained dermatologist assessed the presence or absence of concomitant rosacea and assessed its severity according to the Investigator's Global Assessment (IGA). RESULTS: Fifty-one (46.4%) subjects with BCC and concomitant clinically diagnosed rosacea were found. In our group 35.5% of women had BCC located on the cheeks, while in men most cancers were located on the nose (55%, n = 11), however this difference has not reached statistical significance. CONCLUSIONS: The incidence of rosacea in our population was undoubtedly higher, comparing to the normative population. Both rosacea and BCC share the same risk factors - UV exposure, the potential association should not be neglected. PMID:38028413 | PMC:PMC10646708 | DOI:10.5114/ada.2023.130523 {url} = URL to article