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Facial Flushing and Erythema of Rosacea Improved by Carvedilol.

Dermatol Ther. 2020 Nov 11;:e14520

Authors: Seo BH, Kim DH, Suh HS, Choi YS

Abstract
BACKGROUND: Flushing and erythema are the most common symptoms of rosacea; however, management of these symptoms remains challenging. Recent case studies suggest that treatment with carvedilol may reduce facial flushing and persistent erythema in the pathogenesis of rosacea.
OBJECTIVE: To find the effect of carvedilol in the treatment of facial flushing and erythema in rosacea.
METHODS: Twenty-four rosacea patients treated with carvedilol for facial flushing and erythema were retrospectively reviewed. All patients were prescribed carvedilol 6.25 mg either once or twice per day, and the daily dose was gradually titrated up to 12.5 mg. Clinical erythema severity was assessed by the Clinician's Erythema Assessment (CEA) and Patient's Self-Assessment (PSA) scales. Improvement of CEA and PSA scores compared to the baseline were assessed. The proportion of patients with improvement of 2 or more points from baseline in CEA score was analyzed by sex, previous treatment exposure, disease duration, and subtypes.
RESULTS: The mean change of -1.6 in the CEA score and of -1.8 in the PSA score showed significant improvement from baseline. Erythematotelangiectatic rosacea (ETR) patients achieved more than 2-points improvement in the CEA score, compared with non-ETR patients (53.8% VS 16.7% [P = 0.035]). No statistically significant differences were observed by sex, disease duration, or previous treatment exposure. No serious adverse event was observed.
CONCLUSIONS: Carvedilol can be an effective and safe treatment option for rosacea patients suffering from facial flushing and erythema. This article is protected by copyright. All rights reserved.

PMID: 33174351 [PubMed - as supplied by publisher]

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Long term management of distinct facial flushing and persistent erythema of rosacea by treatment with carvedilol.