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J Cosmet Dermatol. 2022 Apr 7. doi: 10.1111/jocd.14972. Online ahead of print.


BACKGROUND: Acne is a chronic, inflammatory skin disorder of pilosebaceous units. Tranexamic acid (TXA) acts as a plasmin inhibitor to reduce blood loss, and is also used to treat rosacea due to its anti-inflammatory effects. Some parts of the pathogenesis of rosacea are similar to inflammatory acne.

OBJECTIVES: The study aimed to evaluate the efficacy of 10% TXA serum in treating acne and its adverse effects.

METHODS: A randomized, double-blind, placebo-controlled, split-face study was performed on 18 mild to moderate acne patients. Patients applied 10% TXA serum on one side of the face and placebo on another side twice daily for 8 weeks. Acne lesion counts and adverse effects were evaluated every 2 weeks.

RESULTS: Significant differences in total inflammatory acne counts were observed between TXA and placebo since week 4 (p = 0.008). TXA mainly reduced papules and pustules, as papule counts significantly decreased since the 8th week (p = 0.046) and pustule counts significantly reduced since week 8 (p = 0.033). Moreover, physicians also found that TXA serum reduced the redness of the skin, corresponding with the imaging from VISIA® Skin Analysis. The anti-inflammatory effect of TXA resulted in less PIE and PIH. Adverse effects, including erythema and scaling, were treated by applying any moisturizing cream.

CONCLUSION: Topical 10% TXA can reduce inflammatory acne effectively. Adverse effects were minor and treat easily.

PMID:35388589 | DOI:10.1111/jocd.14972

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