Unraveling AQP3's Role in Rosacea

[Guide]

"Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice....Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea." [1]

"Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene." [2]

"Aquaporins (AQPs) are water channels that facilitate transepithelial water transport across plasma membranes following an osmotic gradient [3]. AQPs are glycosylated integral membrane proteins and widely expressed in bacteria (for review [4]), yeast [5], plants [6] (for review [7]), and mammals..." [3]

Obviously we need more rosacea research on this subject. Do you want to support such targeted research? Join the RRDi and post in this thread. A Graphical abstract of AQP3 [4]

End Notes

[1] PubMed RSS Feed - -Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea 

[2] Aquaporin-3, Wikipedia

[3] Aquaporin-3 in Cancer
Saw Marlar, Helene H. Jensen, Frédéric H. Login, and Lene N. Nejsum
Int J Mol Sci. 2017 Oct; 18(10): 2106.
Published online 2017 Oct 7. doi: 10.3390/ijms18102106

[4] Biochimica et Biophysica Acta (BBA) - Biomembranes
Volume 1861, Issue 4, 1 April 2019, Pages 768-775
Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3
Roberto A. Rodriguez, Huiyun Liang, Liao Y. Chen, Germán Plascencia-Villa, George Perry