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Rosacea linked to Alzheimer's Disease


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Rosacea Linked to Slightly Increased Risk for Alzheimer's Disease
By Jody Smith, EmpowHER,  June 3, 2016

Daily MailHealth24Fox News

"Recently, an increased interest has been shown in the potential associations between neurodegenerative diseases and rosacea. For example, a nationwide cohort study from Denmark explored the relationship between rosacea and neurodegenerative diseases such as Parkinson’s disease. MMPs are believed to be associated with the neurodegenerative diseases and an increased expression of MMP-1 and MMP-9 has also been observed in rosacea. In addition, another Danish study found that rosacea was significantly associated with dementia, especially Alzheimer disease. AMPs, MMP, and inflammatory cascades, which have a shared impact on both rosacea and Alzheimer disease, are considered to be involved in the underlying mechanism. Together, these findings suggest that a pathogenic link might therefore exist between rosacea and neurodegenerative diseases."
Int J Mol Sci. 2016 Sep; 17(9): 1562.
Published online 2016 Sep 15. doi:  10.3390/ijms17091562, PMCID: PMC5037831
Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition
Yu Ri Woo, Ji Hong Lim, Dae Ho Cho, and Hyun Jeong Park,

"Rosacea is significantly associated with dementia, particularly AD. Increased focus on symptoms of cognitive dysfunction in older patients with rosacea may be relevant."
Ann Neurol. 2016 Jun;79(6):921-8. doi: 10.1002/ana.24645. Epub 2016 Apr 28.
Patients with rosacea have increased risk of dementia.
Egeberg A, Hansen PR, Gislason GH, Thyssen JP.

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“The root cause of Rosacea is different than your standard teenage acne. There seems to be blood vessel involvement. And a lot of inflammation that accumulates around the blood vessels,” says Dr. Cindy Lamerson with the Nevada Center for Dermatology.....“Like we like to say in science and medicine: correlation is not causation. But it is an interesting thing that may be happening. There might be an inflammatory component that we don't understand very well; that is also involved in the proteins that kind of accumulate with Alzheimer's,” say Dr. Lamerson. Dr. Lamerson says while these Denmark findings may cause alarm to those who have Rosacea, she says the study does not show the skin disorder causes Alzheimer’s Disease or Parkinson’s Disease or that the patient will develop either disease.

Rosacea and possible link to Alzheimer's Disease, RENO, Nev. (KOLO) 8 ABC

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