Topical Timolol Maleate 0.5% for Rosacea

[Guide]

Johns Hopkins University is sponsoring a clinical trial of using Timolol for the Treatment of Acne and Rosacea which started in March 2016, with an Estimated Primary Completion Date of March 2019 and an Estimated Study Completion Date of March 2021. [1]

Timolol (brand names Betimol, Istalol) is "a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension." DrugBank

A study concluded that topical timolol maleate 0.5% is 'expected to be beneficial' in improving 'both acne and rosacea':

 "In our study, topical timolol maleate 0.5% demonstrated effectiveness in the treatment of acne, especially in noninflammatory lesions, but seems to be more effective in erythematotelangiectatic rosacea than papulopustular rosacea lesions, with insignificant side effects. The addition of topical timolol to the standard treatment protocol for acne and rosacea is expected to be beneficial, especially by way of improving comedones of acne and resistant inflammatory erythema of both acne and rosacea."

J Clin Aesthet Dermatol. 2020 Mar; 13(3): 22–27.
Efficacy of Topical Timolol 0.5% in the Treatment of Acne and Rosacea: A Multicentric Study
Sahar M. Al Mokadem, MD, Al-Shimaa M. Ibrahim, MD, and Abeer M. El Sayed, MBChB

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J Am Acad Dermatol. 2021 Feb 03;:
Topical Timolol 0.5% Gel-Forming Solution for Erythema in Rosacea: A Quantitative, Split-Face, Randomized, and Rater-Masked Pilot Clinical Trial.
Tsai J, Chien AL, Kim N, Rachidi S, Connolly BM, Lim H, Alessi César SS, Kang S, Garza LA

End Notes

[1] Timolol for the Treatment of Rosacea