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Parkinson's Disease and Its Dermatological Associations: Is Your Skin Whispering You a Diagnosis?

Cureus. 2020 Aug 22;12(8):e9933

Authors: Shah P, Sagar PR, Alhumaidi N, Bollampally VC, Malik BH

Abstract
Parkinson's disease (PD) is a neurodegenerative disease characterized clinically by the triad of resting tremor, rigidity, and bradykinesia. Although PD is primarily known for motor disturbance, 98.6% of patients experience one or more non-motor symptoms at all stages of the disease. Dermatological disorders are discussed as common non-motor associations of PD since the 20th century. Many studies have shown that patients of PD are predisposed to skin disorders. This article is a traditional review done to analyze the association between PD and its dermatological manifestations. We did a literature search using six keywords in the PubMed database and took the relevant articles published in the last 10 years. We reviewed more than 100 articles, which also included animal studies. On meticulous review, we observed an increased incidence of certain skin disorders like seborrheic dermatitis, bullous pemphigoid, rosacea, and melanoma in patients of PD. These disorders share either common risk factors or underlying mechanisms revolving around genetics, immunology, inflammation, and pathophysiology of PD, but the exact causation yet seems obscured. We believe that this opens a horizon for more research in the link between the skin and nervous system. We also emphasize that the dermatologists, neurologists and general physicians should address the cutaneous disorders in PD timely, educate their patients, help them lessen the psychosocial distress, and improve their quality of life.

PMID: 32968594 [PubMed]

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Do you think that any rosacea non profit organization would do any research as this paper suggests, "that this opens a horizon for more research in the link between the skin and nervous system,"?  Most of the research on rosacea is profit motivated since the skin industry promotes and sponsors most of the clinical research papers on rosacea. In comparison to non profit rosacea research who would investigate this? Could a grassroots non profit organization for rosacea gather enough donations to investigate this subject?  What do you think?  For more information. 

Are you aware that PD is also associated with lewy body dementia?