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PubMed RSS Feed - -Method R: Efficacy of a cosmetic routine comprising six topical lipid-encapsulated products


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J Cosmet Dermatol. 2022 Jan 23. doi: 10.1111/jocd.14747. Online ahead of print.


INTRODUCTION AND OBJECTIVE: Efficacy of cosmetic routines is reportedly available in several dermatological conditions, such as acne or rosacea. However, clinical evidence about objective advantages of skincare routine remains limited despite advertising often claims benefits.

METHOD: We aimed to assess the subject satisfaction level and the benefit from daily use of an advanced skincare routine named Method R. We used four different approaches to try and demonstrate the efficacy of the method: Transdermal delivery test, ex-vivo efficacy test, Visioscan® VC 20, and patient survey. MetR consists of a six-step routine that shows an increased epidermal penetration and activity due to liposomation.

RESULTS: Transdermal delivery test and ex-vivo efficacy test show increased efficacy for liposomated actives. The skincare routine is well tolerated, and is associated with a marked efficacy in global quality of skin, dyschromia/pigmentation, brightness, and hydration according to patient perception. The subject satisfaction level is high and the routine is safe. The continuous use of the routine for one month or more results in objective changes when measured with Visioscan® VC 20 plus.

PMID:35066958 | DOI:10.1111/jocd.14747

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Liposomated means "incorporated into liposomes" according to Wiktionary and Wordsense. Liposome is "an aqueous compartment enclosed by a bimolecular membrane, typically of phospholipid; a lipid vesicle."

The Visioscan® VC 20 plus is a unique UVA-light video camera with high resolution to study the skin surface directly. More Info.


The above report mentions that "clinical evidence about objective advantages of skincare routine remains limited despite advertising often claims benefits." Two of the authors of the paper are affiliated with Nanovex Biotechnologies, Asturias, Spain which according to its website "works in the design and development of different nanovesicles  to encapsulate different compounds.' The other two authors of the paper are associated with Clinica Dermatologica Internacional, Madrid, Spain

Wouldn't it be novel for the RRDi to independently sponsor a paper like this to evaluate skincare routines using similar equipment conducted by independent clinicians that are not affiliated with the skin industry?  Would you help in sponsoring such a study?  If enough members of the RRDi got together and decided this is what needs to be done it would take about $10K. The RRDi has currently 1600 plus members which would mean that each member would need to contribute $6.25 (less than a meal at a fast food chain). Can you see how a non profit organization has power if the members simply got together and decided to do something. What about you?  Can you find the reply to this post button and make a comment about this?  

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