Guide

"Because of its implications in many of these factors, diet has been a part of the acne discussion for decades. Several studies have evaluated the significance of the glycemic index of various foods and glycemic load in patients with acne, demonstrating individuals with acne who consume diets with a low glycemic load have reduced acne lesions compared with individuals on high glycemic load diets....Multiple studies have shown that Americans are consuming too much added sugars, fat, carbohydrate, and sodium and too few whole grains...Two randomized controlled trials have shown that low-GL diets reduce acne lesion counts, body weight, and body fat compared with a carbohydrate-dense control diet in people with acne [39, 52]. Another study involved patients with mild-to-moderate acne randomized to either a low-GL diet or a high-GL diet for 10 weeks [53]. Those on a low-GL diet demonstrated significant reductions in noninflammatory and inflammatory lesion counts, smaller sebaceous glands, decreased inflammation, and reduced acne severity grading...There is strong support for the reduction of acne with regular consumption of omega-3 fatty acids and low-GI and low-GL diets."

Am J Clin Dermatol. 2021; 22(1): 55–65.
Published online 2020 Aug 3. doi: 10.1007/s40257-020-00542-y
Effects of Diet on Acne and Its Response to Treatment
Hilary Baldwin and Jerry Tan

February 11, 2021

To understand what is happening with skin industry rosacea research and social media you simply have to know the facts.

Without a doubt most of the rosacea research is sponsored by the skin industry, particularly pharmaceutical companies and cosmetic manufacturers. [1] The skin industry is using social media to advertise to set trends.

"Conservative estimates valued the global beauty industry at over $300 billion in 2018, according to a report from Trefis, a financial research and analysis firm. The global skincare market was valued at nearly $135 billion in 2018, increasing nearly 60% in the past 10 years. And Trefis projects it to reach $180 billion — an increase of over 30% — in the next five years." [2]

"Social media has opened up new avenues for purchasing and discussing skincare routines and trends." [2]

"The global cosmetics industry should be worth 438.38 billion by 2026." [2]

"Women in the US spend around $3,756 on cosmetics annually." [3]

"82% of women believe that social media drives trends." [3]

"The beauty industry is valued at $532 billion and is on a rapid upward trajectory, according to a new report from retail analytics firm Edited." [4]

"Cosmetics and personal-care companies will continue to benefit from social media influencers and brand ambassadors, even as they increasingly pivot to sustainable beauty and increased transparency in both manufacturing and pricing, the report stated." [4]

"At the same time, social platforms have evolved to be more shoppable by allowing consumers to purchase items they see in a post directly from the app. Thanks to features like Instagram Shopping and Pinterest's shoppable Pins, if consumers see an item they like, they can click on it to learn more and subsequently make a purchase." [4]

"One of the recent beneficiaries is IT Cosmetics, started less than a decade ago by former TV Broadcast journalist Jamie Kern Lima. She began working on her beauty line after developing hereditary rosacea and realizing that most foundations made her skin look worse. She wanted to create a formula that could work on women with skin problems like acne, wrinkles or rosacea." [5]

"Retailers Sephora and Ulta also provide a huge boost to small upstarts with potential, while consumers are willing to give different brands a try, especially those with strong followings on social media, like IT Cosmetics." [5]

"Another report from Statista projected that the global cosmetics market is projected to value at about 758.4 billion U.S. dollars by 2025." [6]

"The global skin care products market size is projected to reach USD 183.03 billion by 2025 expanding at a CAGR of 4.4%, according to a new report by Grand View Research, Inc. Increasing demand for natural, herbal, and organic products that have no adverse effects is expected to boost the market growth over the forecast period. Skin care products include various synthetic and natural products, such as body lotions and face creams. Rising concerns regarding skin problems are also driving the skin care products industry." [7]

"As per the report published by Fior Markets, the global beauty and personal care products market is expected to grow from USD 493.34 billion in 2018 to USD 756.63 billion by 2026, at a CAGR of 5.81% during the forecast period 2019-2026." [8]

Rosacea Research in Perspective of Funding

Rosacea Research in Perspective of Idiopathic Diseases

Conclusion
As you can see from the above stats that there is plenty of money in the skin industry which uses social media to advertise and what small amount of rosacea research is being done, the vast majority is being sponsored by the skin industry. The huge amount of skin industry research is focused on other skin conditions that have a more devastating impact on sufferers, i.e., melanoma, psoriasis. There is way more research done on acne than on rosacea by the skin industry. And while some of the research be done on rosacea is without a doubt helpful to rosacea sufferers, do you think that the skin industry has an agenda in what research is being done, or possibly a bias in what is sponsored for research? For example, what research was sponsored by the tobacco industry that probably was biased? Do you think the skin industry may have similar motives? Why does the pharmaceutical skin industry continue to sponsor the NRS, AARS, and the ARSC with millions of dollars, non profits whose board of directors are all businessmen or dermatologists, while ignoring requests for donations to the RRDi, a grassroots, patient advocacy non profit for rosacea?

Furthermore, since rosaceans have gone over to social media, could you volunteer to post or be a moderator of the RRDi social media accounts?

Would you like to see some independent rosacea research being done by rosacea sufferers? Join the RRDi. Help make a difference.

End Notes

[1] Rosacea Research Update

[2] The skincare industry is booming, fueled by informed consumers and social media, Ahiza Garcia, CNN Business

[3] 45 Absolutely Astonishing Beauty Industry Statistics for 2021, Ljubica Cvetkovska, LoudCloud Health

[4] Beauty has blown up to be a $532 billion industry — and analysts say that these 4 trends will make it even bigger, Bethany Biron, Business Insider

[5] Why The $445 Billion Beauty Industry Is A Gold Mine For Self-Made Women, Chloe Sorvino, Forbes

[6] Cosmetics/Skin Care Market Could Exceed US $750 Billion by 2025, Financialnewsmedia.com News Commentary

[7] Skin Care Products Market Worth $183.03 Billion By 2025 | CAGR: 4.4%, Grand View Research

[8] Global Beauty and Personal Care Product Market is Expected to Reach USD 756.63 Billion by 2026 : Fior Markets, Intrado Global Newswire

February 10, 2021

On 12/26/2020 at 10:12 AM, 7Cecile7 said:

Hello Brady,

I wanted to offer some explanation as to why I've not been active on this forum. First of all it's the structure of a forum. Personally, I have a challenge navigating them. For me & how my brain works I just haven't done well with seeing/understanding how to navigate forums so I've not engaged in them very much. Unlike Reddit which I've recently joined for the reselling community posts I've never noticed RRDI to send you a thread that you've posted on directly to you like Reddit does, so I will click on the heading & see what was just written & then I'll respond, otherwise I don't go on to reddit & search etc.,. I don't understand how to navigate Reddit much either and it's not a priority. Visually too much going on. I am not on social media/FB much at all especially since my husband left our marriage unexpectedly a few years ago, but when we were together & I was dealing with a lot of other health issues & my parents health issues & focusing on him & his music career. I've had a lot of health issues & life losses that have eclipsed rosacea so that it fell to the bottom of the list.

For me I've found that my acne rosacea is triggered by allergies & sensitivities that are odd so they wouldn't be easily caught. I had to eliminate these sources as much as possible, some of which are not always possible for example shopping in stores pre-pandemic my face would break out as I'm reactive to formaldehyde resin which is sprayed on a ton of items found in my fav TJ Maxx, Marshalls & Homegoods (especially) stores. I'd go out that day with a perfectly clear face & shop for several hours & end up with 4-6 rosacea pimples by the end of the night. A friend of mine joked that we should record it.

Wearing a surgical mask makes my face break out, yes the surgical ones, because they have some sort of chemical on them. Titanium dioxide, coco-betaine & prior even foods triggered it. I have to wash my face twice a day with Honest brand face cleanser as it is free of coco-betaine which is the main cleansing ingredient in all hand soaps, shampoos & cleansers. I use Dessert Essence Free (something) shampoo & conditioner because it is free of coco-betaine & I found two hand pump cleansers free of that ingredient as well. I use a handful of other skincare products (too many to list) including Renee' Rouleau's line which is fabulous, she has a acne spot treatment which will eliminate the red rosacea bumps overnight. I use titanium dioxide free makeup as well.

Another odd thing is I can use this amazing lotions, creams on my face & it helps my face but if I put it on my neck it'll break out in hives so I'm still trying to discern which ingredient I'm allergic to now, it's coming down to aloe vera & rosemary as well as blue tansy. My body chemistry is constantly changing with some health issues leaving while others enter in, including new sensitivities that give me pseudo allergic reactions even affect my heart rhythm etc., and traditional doctors do not want to hear this type of thing so I just stay away from the docs, work with a great integrative nutritionist & my own research & live a life of continuous evolving experimentation.

I have my own website beingwellwithmichelle.com that I've not posted on in about 2 years nevermind engage on. I may get back to it this year but I"m not sure. I look at the photos of me on there & they were from 2012 or so & I don't recognize that sweet innocent 40 something. I had high hopes for my life/wellness coaching practice working with other high achieving women with chronic health challenges but due to the marriage ending & all that went with that I had to focus on my mindbodywellness & not on helping others.

So many things going on in my life just trying to survive & put myself & my self-care first has been my priority & now with the pandemic things are even more disjointed. I spent over 35 years trying to figure out my health challenges rosacea being the most obvious to others & the one that first came around age 20 when I got Lyme disease then disappeared & returned 20 plus years later & I'm 51 now & still am learning how it expresses itself in my body. For now I've got it under control which is nice. I take a mindbodyspirit approach combining a bunch of philosophies & a metaphysical approach to wellness too.

I hear these people with COVID-19 speak about "long haul" symptoms & that's been the story of my life since I got mono at age 15 but doctors looked at me like I was crazy. I've had 3/4's of the symptoms people have talked about COVID causing in all systems. I had Lyme disease as well yet it wasn't properly diagnosed. I got on doxycycline for the rosacea outbreak at age 20 & within a few months my neurological symptoms left. I had tested positive ANA factor, RH factor & had signs of infection but back in the late 80's no one was putting it all together with Lyme as they do now.

To be honest, I had to take a giant step back & just try to live & do & be instead of constantly focusing on what is wrong with me & that included stepping away from the rosacea forum among many others.

I started reselling clothes online & that has been a nice distraction from illness & dysfunction. I want to still help others including sharing my experiences with rosacea but I'm not sure exactly what that's going to look like. It seems each year when I think I'm going to get off of SSDI & work again another life or health tragedy strikes & I'm just at that point of trying to live under the radar. I'm literally alone in my condo daily & haven't seen anyone in a year except for a handful of people at a distance, grocery shopping, dropping off things to my Dad etc., I've not even been able to see my Mom due to her being in a nursing home facility. I got sick last year with a respiratory virus that I've still not fully recovered from & that was last Dec-this April. So I got a head start on the quarantine.

So I apologize for not being more active here or anywhere actually, but to be honest there have been so many other things going on that I've just not wanted to focus on illness & issues whenever I don't have to. I hope you can understand.

Cecile,

Thanks for you post. Obviously rosaceans don't like forum style platform and prefer social media since that is why I made this post and video. I am so used to it and the similar forum at RF that it is second nature to me. I find social media platform not to my liking. I try to navigate Facebook and Reddit but just can't understand why rosaceans prefer it but such is the nature of humans.

I understand you have limitations and appreciate your health is a difficult struggle. If you can think of something you would like to do for our non profit, I am all ears to find something you can do. For example, since you don't social media (I feel the same way you do about social media), you do mention you use Reddit some, could you be a moderator at our Reddit account since I don't like handling that job at all at Reddit and sure could use the help? If not, try to think of something. My recommendation is to setup your own rosacea blog which is free, which the RRDi sponsors, and you can learn how to do this by reading this post. Or another option is simply to post in our community support forum and stay in that category of our forum. If you can post some you may win a free jar of the ZZ cream!

February 9, 2021

Baumann Skin Types Bingo Card image courtesy of Wikimedia Commons

The Baumann Skin Type Indicator (BSTI) is a phenotype "classification system [that] has been adopted by estheticians, dermatologists, consumers and retailers to match cosmeceutical ingredients and skin care products to specific skin types." [1]

"By evaluating skin according to these parameters--dry or oily, sensitive or resistant, pigmented or nonpigmented, and wrinkled or unwrinkled--and thus differentiating among the 16 permutations of possible skin types, consumers can more easily identify the most suitable topical treatments for their skin." [2] So instead of Normal, Dry, Oily, Combination or Sensitive Skin which most people are familiar with, Dr. Baumann came up with what has been used "to subdivide research participants into specific phenotypes. She assigns binary values to four characteristics, so defining sixteen "skin personalities", or "skin types". These have been used in genetic research aimed at identifying the genes that contribute to skin characteristics such as dryness, oiliness, aging, pigmentation and sensitivity." [1]

“Properly identifying skin type is key for positive skin care outcomes,” says Dr. Baumann. “But the problem with the traditional classifications (normal, dry, oily and combination) is that they provide very little information about the skin.” [3]

Dr Leslie Baumann goes into details for all 16 Baumann Skin Types on her website. [4]

Dr. Baumann is recognized for her research into cosmetics and dermatology and has written a world class book on the subject, Cosmetic Dermatology, as well as her book, The Skin Type Solution. [5] Dr. Baumann practices at the Baumann Cosmetic and Research Institute in Miami, Florida.

End Notes

[1] Baumann Skin Types, Wikipedia

here

[3] The Baumann Skin Type: What It Is and How Do You Determine Yours?, Marilyn Oliveira, Dermstore

[4] What are the 16 Baumann Skin Types?

[5]

February 9, 2021

Butyric Acid*

"To date, oral and topical probiotics for the skin microbiome play an important role in treating inflammatory skin diseases, atopic dermatitis, acne, rosacea, wound healing, and skin cancer." [1]

"These results demonstrate that butyric acid (BA) in the metabolites of fermenting skin probiotic bacteria mediates FFaR2 to induce the synthesis of collagen through p-ERK activation. We hereby imply that metabolites from the probiotic S. epidermidis fermentation of CIN as a potential carbon source could restore impaired collagen in the dermal extracellular matrix (ECM), providing integrity and elasticity to skin." [1]

"Butyric acid (from Ancient Greek: βούτῡρον, meaning "butter"), also known under the systematic name butanoic acid, is a straight-chain alkyl carboxylic acid with the chemical formula CH3CH2CH2CO2H. It is an oily, colorless liquid with an unpleasant odor. Isobutyric acid (2-methylpropanoic acid) is an isomer. Salts and esters of butyric acid are known as butyrates or butanoates. The acid does not occur widely in nature, but its esters are widespread. It is a common industrial chemical[7] and an important component in the mammalian gut." [2] (bold added) Do You Have a Gut Feeling About Rosacea?

"Salts and esters of butyric acid are known as butyrates or butanoates." [2]

"Although the role and importance of butyrate in the gut is not fully understood, many researchers argue that a depletion of butyrate-producing bacteria in patients with several vasculitic conditions is essential to the pathogenesis of these disorders. A depletion of butyrate in the gut is typically caused by an absence or depletion of butyrate-producing-bacteria (BPB). This depletion in BPB leads to microbial dysbiosis." [2]

"Metabolites from the human probiotic bacteria Staphylococcus epidermidis (S. epidermidis) fermentation of different carbon sources such as sugar or polymers have been found to protect skin from inflammation in response to stress. The oral administration of probiotics could effectively heal wounds through the deposition of collagen on them." [1]

"Studies have evidenced that probiotics accelerate the fibrosis process, causing the deposition of collagen." [1]

Topical and Oral Probiotics Available in the RRDi Affiliate Store

Butyric Acid Supplements

End Notes

*Space filling model of butyric acid image courtesy of Wikimedia Commons

[1] Int J Mol Sciv.22(3); 2021 Feb PMC7866835
Probiotic Activity of Staphylococcus epidermidis Induces Collagen Type I Production through FFaR2/p-ERK Signaling
Indira Putri Negari, Sunita Keshari, and Chun-Ming Huang

]2] Butyric acid, Wikipedia

February 7, 2021

Paeonia lactiflora image courtesy of Wikimedia Commons

"Paeoniflorin is a chemical compound which is one of the major constituents of an herbal medicine derived from Paeonia lactiflora. It can also be isolated from the fresh water fern Salvinia molesta." Wikipedia

Salvinia molesta image courtesy of Wikimedia Commons

Peony image courtesy of Wikimedia Commons

"The peony or paeony is a flowering plant in the genus Paeonia, the only genus in the family Paeoniaceae. Peonies are native to Asia, Europe and Western North America.....The herb known as Paeonia, in particular the root of P. lactiflora (Bai Shao, Radix Paeoniae Lactiflorae), has been used frequently in traditional medicines of Korea, China and Japan."
Wikimedia

February 5, 2021

Chalcone, the structural backbone of chalconoids*

An article discussing the pharmacological properties of chalcones had this to say about rosacea:

"A subsequent study on 33 rosacea patients showed that the skin care products with licochalcone A are compatible with the standard topical treatment of the disease." [1]

"Licochalcone A is a chalconoid, a type of natural phenol. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata. It shows antimalarial, anticancer, antibacterial and antiviral (specifically against influenza neuraminidase) properties in vitro." [2]

End Notes

*image courtesy of Wikimedia Commons

[1] Front Pharmacol. 2020; 11: 592654.
Published online 2021 Jan 18. doi: 10.3389/fphar.2020.592654
PMCID: PMC7849684
PMID: 33536909
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
Bahare Salehi, Cristina Quispe, 2 Imane Chamkhi, Nasreddine El Omari, Abdelaali Balahbib, Javad Sharifi-Rad, Abdelhakim Bouyahya, Muhammad Akram, Mehwish Iqbal, Anca Oana Docea, Constantin Caruntu, Gerardo Leyva-Gómez, Abhijit Dey, Miquel Martorell, Daniela Calina, Víctor López, Francisco Les

[2] Licochalcone A, Wikipedia

Topicals that contain Licochalcone A

Eucerin Redness Relief Day Lotion

Chalcone Over the Counter Oral Treatments

February 5, 2021

*

A significant number of rosaceans complain of dry skin. A reusable wireless device is available to dermatologists, called a skin hydration sensor (SHS), which is "a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication–compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature)."

The article discussing this device does mention rosacea once here:

"Key results include clinical use of the SHS on n = 13 patients with a wide range of inflammatory skin conditions (e.g., AD, psoriasis, urticaria, xerosis cutis, and rosacea), with benchmarks against standard tools to quantitatively characterize the diseased locations."

Whether this device can be used to assist dermatologists with rosacea remains to be seen.

*image courtesy of Science Advances

Sci Adv. 2020 Dec; 6(49): eabd7146.
Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment
Surabhi R. Madhvapathy, Heling Wang, Jessy Kong, Michael Zhang, Jong Yoon Lee, Jun Bin Park, Hokyung Jang, Zhaoqian Xie, Jingyue Cao, Raudel Avila, Chen Wei, Vincent D’Angelo, Jason Zhu, Ha Uk Chung, Sarah Coughlin, Manish Patel, Joshua Winograd, Jaeman Lim, Anthony Banks, Shuai Xu, Yonggang Huang, John A. Rogers

February 4, 2021

"The team said the portable skin mapping (imaging) device could be used to assess the severity of skin conditions, such as eczema and psoriasis." [1]

Whether this skin mapping device could be used for rosacea remains to be seen.

End Notes

[1] Science Daily - Team develops portable device that creates 3D images of skin in 10 mi

February 2, 2021

Microorganisims of the skin microbiome is now being researched more than ever and a recent article elucidates this subject and discusses rosacea:

"Rosacea has also been linked to a dysbiosis of the skin microbiome. An increased abundance of Demodex mites are observed in this disease. An interesting suggestion was made by Parodi et al. who reported an interplay between the skin and bacterial overgrowth in the small intestine. Rosacea patients had a significantly higher overgrowth of gut bacteria than controls and elimination of the overgrowth, using an antibiotic, resulted in an almost complete regression of the skin pathology for a prolonged time. These findings support the pathogenetic role of the gut microbiome in rosacea lesions, although the exact relationship remains to be elucidated. Additionally, research even investigated the microbiota of the Demodex mites, but final conclusions are still outstanding." [1]

Transplant Treatment Methods
"Transplantation of a complete microbiome or application of single strains has demonstrated beneficial therapeutic application." [1]

The first method discusses skin microbiome transplantation, where "the skin microbiome of a healthy individual is transferred to the washed and/or disinfected skin area of another person with the aim of improving the skin condition of the latter." [1] A second method is "skin bacteriotherapy, where one or multiple pure cultures with health-promoting properties are placed on the washed and/or disinfected skin area of a person." [1]

"A third method of changing the skin microbiome is through prebiotic stimulation. In this process, prebiotics are supplemented to the skin to stimulate the growth of specific health-promoting microbes. A prebiotic is an ingredient with a bioselective activity that exerts a beneficial effect on the host and attempts to improve the host's health." [1]

The fourth method has been around for some time now which is, "Microbiome transplantation for humans is not new and is best known by the example of faecal microbiota transplantation (FMT) for the treatment of gastric Clostridium difficile infections." [1] We have discussed this before in a post, Baby You Can Drive My Gut.

Bacteria is the Main Focus
While this article focuses mainly on bacteria, as most papers on this subject do the same, it does refer to a token mention of fungus, demodex and virus and ignores protozoa, archea, helminths, or any other microbe.

It is worth reading. We should make a TikTok video on this subject, because reading the article is a deep dive for most rosaceans.

If you appreciate this post, why not show your appreciation with your comment by finding the REPLY TO THIS TOPIC button on the device you are using now?

End Notes

[1] Comput Struct Biotechnol J. 2021; 19: 624–631.
Skin microbiome transplantation and manipulation: Current state of the art
Chris Callewaert, Nastassia Knödlseder, Ante Karoglan, Marc Güell, and Bernhard Paetzolde,

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