Guide

A detailed report on cannabinoid signaling in the skin had this to say: 

"It has recently been shown that abuse of synthetic, hyperpotent cannabinoids (e.g., “Bonsai”, “fake weed”, “K2”, and “Jamaica”) can result in dermatological disorders, such as premature skin aging, hair loss and graying, or acne [88], indicating that cannabinoid signaling can profoundly influence skin biology."

"Importantly, with respect to the efficiency of PEA, human clinical data are also available. Indeed, the PEA containing Physiogel® A.I. Cream was found to alleviate itch in 14 out of 22 patients suffering from prurigo, lichen simplex and other pruritic diseases. Importantly, the same formulation was found to be effective in alleviating erythema, excoriation, scaling, lichenification, dryness, as well as pruritus in AD patients (ATOPA study). However, another vehicle controlled, randomized clinical trial involving a total of 100 subjects suffering from pruritic dry skin (ClinicalTrials.gov ID: NCT00663364) found that a PEA containing lotion was not significantly superior in alleviating itch as compared to its emollient vehicle."

PEA is Palmitamide MEA, a naturally occurring lipid compound that may act as an anti-oxidant and anti-irritant.

Molecules. 2019 Mar; 24(5): 918.
Published online 2019 Mar 6. doi: 10.3390/molecules24050918
Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System
Kinga Fanni Tóth, Dorottya Ádám, Tamás Bíró, Attila Oláh

A sample of food-grade diatomaceous Earth 
Courtesy of Wikimedia Commons

Diatomaceous earth - also known as D.E., diatomite, or kieselgur/kieselguhr – is a naturally occurring, soft, siliceous sedimentary rock that is easily crumbled into a fine white to off-white powder. Wikipedia

Can it be used to treat demodectic rosacea?  At least one person thinks so. 

This was posted initially at Facebook, diatomaceous earth mixed with honey improves rosacea. 

Without a doubt, since it was posted on Facebook, others will try this and we receive more reports  since you can obtain food grade diatomaceous earth below and other mediums besides honey will be attempted and the results will be coming in. 

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A number of anecdotal reports are using diaper rash treatments for rosacea. A typical example is Sarah Ann, Rosacea Tips and Support Group, Facebook,  who posts "This is gonna sound kinda crazy but I’ve tried almost everything for my rosacea and finally a couple days ago I was got so desperate I tried using my daughters diaper rash cream lol. It must be the zinc in it but after 2 days of it my skin is better than ever! The brand is Weleda Baby. Any one else try anything like this? I’m amazed!" There are hundreds of others who report trying this treatment and using different brands and rave about it. Just search 'diaper rash treatment for rosacea.' Here are two more examples: 

A poster at the exclusive, private group, Rosacea Tips and Support Group, Facebook, posts, "This is the one I use [Honest Diaper Rash Cream] and recommend all the time in this group. It's for healing dehydrated skin. I also use it to calm irritation from a flare, and I apply a very thin layer under my makeup which keeps my skin soothed until washing it off. The opaque color also masks redness. I see so many people recommending this brand now so I must have started a revolution."

Another poster at Rosacea Tips and Support Group, Facebook, posts, "I started Boudreaux's Butt Paste today. It has the highest Zinc content at 40%."

If you try this treatment, please post your results in this thread. 

"Quite simply, “groat” is the old Scottish word for the entire oat kernel minus the husk....Oat Groats are the whole grain - germ, bran, and endosperm - without having been rolled or steel cut!....Steel Cut Oats: Steel cut oats are whole oat groats that have been cut into two or three pieces. That's it." The Oatmeal Compendium

There is discussion at RF started by butler that making a paste from oat groats or steel cut oats will clear your Rosacea/Seborrheic Dermatitis. It is a long thread but some report that it works, especially if you are into a natural treatment for your Rosacea/Seborrheic Dermatitis. Some prominent posters like Tom Busby. sejon, MrRed77, rednasstor are really into this. One method used to make the paste is to put the oats into a coffee grinder and add water to make the paste. 

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Thanks for the tip Apurva. Finding a SUN BLOCK is not easy, however, I found one: 

You may find this sunscreen interesting even though you said sunscreens tend to dry your skin, probably one like this? 

The Neutrogena Hydro Boost may be better for your skin or the Neutrogena Clear Face Sunscreen?

I tried to find 'sun block' at Amazon and I just get a list of sunscreens and only found that one. I will keep searching. 

The RRDi has collected a number of cosmetics to consider in your search by using our affiliate store.  

Thanks Apurva Tathe for your posts. 

Would fasting improve rosacea? One recent report says, "Another study performed by Smith et al. in 2008 has shown the beneficial impact of caloric restriction on acne vulgaris lesions. This was explained by decreased sebum production, which thereby counterbalances one of the main factors in the pathogenesis of acne vulgaris.....Despite such important practical implications, this topic has been neglected in the existing scholarly literature, when it deserves further research. High-quality randomized controlled trials (RCTs) should be conducted to systematically explore and compare different fasting protocols, including the use of vegetables and fruits for caloric and metabolic manipulations." [1]

Wouldn't it be a novel idea to get 10K RRDi members together and each donate one dollar and offer $10K to one of our RRDi MAC members to conduct a clinical trial on this. 

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End Notes

[1] Fasting and Its Impact on Skin Anatomy, Physiology, and Physiopathology: A Comprehensive Review of the Literature

A poster at the exclusive, private Facebook group, started a thread about using Ichthammol for her rosacea, and reported it worked for her. 

Ichthammol is Ammonium bituminosulfonate, "a product of natural origin obtained in the first step by dry distillation of sulfur-rich oil shale (bituminous schists)....has anti-inflammatory, bactericidal, and fungicidal properties. It is used to treat eczema, psoriasis, Acne rosacea and acne, and it decreases microorganisms in the area surrounding a skin condition. It is commonly used in 10% or 20% concentrate ointment, applied topically." Wikipedia

"Materials made in China (Pinyin transcription: yushizhi and yushizhi ruangao) and offered outside China as Ichthammol or Ammonium Bituminosulfonate are not in line with the definition given for this substance in the United States Pharmacopoeia (USP) or European Pharmacopoeia (Ph.Eur)." Wikipedia

Post your experience with ichthammol ointment in this thread. 

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Romeo Milea has since resigned from the board.


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mac5400 at Reddit, gives a tip to avoid flushing, of taking a supplement, Diamine oxidase (DAO), and writes, "I now take an OTC supplement called UmbrelluxDAO before i eat or drink. It contain the enzymes responsible for metabolizing histamine. And I barely flush anymore. The chronic rosiness on my cheeks has significantly reduced; more than any cream I've ever tried. In combination with a low histamine diet, i think i finally found the "cure" to my "rosacea." It's such a breakthrough for me. This supplement is life-changing."

"Diamine oxidase (DAO), also known as histaminase, is an enzyme (EC 1.4.3.22) involved in the metabolism, oxidation, and inactivation of histamine and other polyamines such as putrescine or spermidine in animals." Wikipedia

Added DAO to the list of anti-flushing treatments. 

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Dimethicone in Soolantra

Someone at Reddit points out an article published in the Tropical Medical Health by Hermann Feldmeier that concludes, "Dimeticones are a family of compounds with a physical mode of action, targeting an Achilles heel of ectoparasites." I found another article that state dimethicone is a pediculocide. I did find this article that says "dimethicone lotion is not an insecticide and instead kills lice by suffocation," which may explain it.

Dimeticone redirects to Polydimethylsiloxane. 

Dimethicone redirects to Polydimethylsiloxane. 

The Wikipedia article on Polydimethylsiloxane says it is used in medicine "in over-the-counter drugs as an antifoaming agent and carminative" with no mention of it being used as an insecticide or kills parasites. 

"Perhaps dimethicone is an old fashioned treatment for head lice, because like you, I can't find a reliable reference for using it as a miticide or arachnicide or insecticide. With lice, sometimes treatments are called any of these 3 terms. "Mite" is an old-fashioned English word, "arachnid" is the scientific term, and "insect" is just plain wrong, for referring to head lice or demodex. Watch out too for chemical names, as there are silicones that are oil soluble, water soluble, and not soluble in either oil or water.  And, I can't find the recommended concentration for treating head lice with dimethicone -- if, ,for example, it's 15%, that would be far too messy to be cosmetically acceptable for trying it on the face. From my personal point of view in formulating, I like only water soluble silicones, because some of them wash out easily with water, but still provide some "slip" (ease of combing hair, or detangling). The other silicones just sit there on the skin or on the hair, and don't do anything useful from an aesthetic point of view." Tom Busby, Post no 7, Rosacea Forum

"Dimethicone doesn't have any biocidal properties. The mode of action on the treatment of headlice is to prevent the adhesion of lice and the louse eggs on to the hair shaft. Headlice produce a strongly adhesive mucus secretion to stick their eggs (nits) to hair. Dimethicone prevents this adhesion and also interferes with the 'foothold' that the adult lice have on the scalp. Dimethicone is not immediate acting and requires several days for its effect to be apparent. It requires thorough combing of the hair after use to remove loosened lice and nits." johnabetts, Post no 8, Rosacea Forum

"Dimethicone was also the main ingredient (first in list) in the Dermalogica Close Shave Oil, no longer available. I have no signs of rosacea in my shaving area - only on the ears and nose, where clearly I didn't apply the shaving oil. The point with a shaving oil is, assuming you shave every day or two, it is very easy to fully cover the area on a very regular basis. I also thought Soolantra cream had good moisturising properties when I used it. Unfortunately it seemed to stop working on killing mites after a while, and I've had longer term success with Zhongzhou cream." antwantsclear, Post no 9, Rosacea Forum

image courtesy of WikiMedia Commons

Just thought I would vent a little since, after all, I founded the RRDi, and no one hardly ever posts, even though there are over 1200+ members, and we know  that many are viewing the posts since we have counters showing the number of views, so we know that rosacea sufferers are learning about rosacea from our website. So I posted about this a while back, Where Have All the Rosaceans Gone?, back in February 2018, which did elicit one reply from RedMage, which is much appreciated, and has as of this date 96 views, so the odds are 1 in 96 that someone will reply to this post. So I have been posting some at Reddit and Facebook to see what is going on, and am appalled at the lack of basic rosacea knowledge, and I have been trying to educate rosaceans and, got a disparaging post from a Reddit poster who I had commended for some good investigative reporting on finding that Soolantra isn't really using Cetaphil as  its 'vehicle base' [1] and was told that "the Rosacea Research & Development Institute (RRDi) is a sham 'institute' operating from a PO Box that conducts no research or development, hasn't published a journal since 2010, and doesn't even publish its 990s like any reputable 501(c)(3) public charity would be expected to. You're not fooling anyone." That really made my day. Here I have devoted countless volunteer hours trying to make the RRDi a non profit rosacea patient advocacy organization and this certainly made me feel blue. It still boggles my mind that rosaceans continue to support and donate to the National Rosacea Society, which is the chief reason we formed the RRDi in 2004 (read this in case you haven't clue about this). Rosaceans actually prefer the NRS and how it spends its donations. Mind boggling to me. 

So just want you to know, that is the 96 that may view this post, that if some of you don't step up to the plate and start volunteering, posting and doing something as a member of the  RRDi that this non profit organization for rosacea may indeed have to close. Then all you got is the NRS, the AARS, and the ARSC. It really is up to you. And I don't mean up to others, I mean up to you. Oh, you will still have your Facebook and Reddit rosacea groups which is what most rosaceans prefer so you will be in good company. Is that really what you prefer?

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End Notes

[1] See end note [3] in this post

In Rosacea News, we have the post about this subject in detail for your information. Please post in this thread your experience using the horse paste, what brand you use, how often you are applying it, and other details and hopefully photos of before and after. Members may post their own blog, club or gallery. 

We have a poll about which brand you are using if you would please participate in this poll, it would be very much appreciated. 

As mentioned earlier in this thread, one of the issues with using an oral horse paste TOPICALLY for rosacea sufferers is usually there is no inactive ingredient list to see what is actually in the paste or gel. However, one poster at Reddit found the list for one of the products, Eqvalan, which is listed for your convenience below:

Eqvalan Oral Paste for Horses Ingredients: 
Ivermectin: 1.87% w/w. 
Titanium Dioxide (E171) 2.0% w/w.
Hyprolose
Hydrogenated Castor Oil
Propylene Glycol
 

Source
Eqvalan_SPC_214477.pdf

Link for the above:
http://www.vmd.defra.gov.uk/productinformationdatabase/SPC_Documents/SPC_214477.DOC

Eqvalan MSDS

EqvalanMSDS.pdf

Link for the above:
https://www.statelinetack.com/ContentFiles/Associated_Content/EqvalanMSDS.pdf

If anyone finds the ingredients in any other horse paste/gel please post in this thread. 

These recommendations are from ElaineA and Tom Busby at RF: 

20 Muleteam Borax powder is available in US grocery stores in the laundry aisle. Price locally for me is currently about $5.59 per box. Borax is used as a water softener for laundry. 
Try washing your washable clothes with some borax powder added to the wash load. Borax powder dissolves best in warm or hot water. For a cold wash, pre-disolving the borax powder in warm or hot water before adding to the wash, would be a good idea.
Instructions on the box recommend adding 1/2 cup of borax powder per wash load.

I don't know for sure that they can live for long on dry clothes, but they might - especially if there is enough oil or body lotion on the clothes or if the clothes are damp. I've read that they can live up to 54 hours on a wet towel. Wool has natural lanolin oil in it which may give them enough oil to survive when their human host is not available.

The wool scarves are trickier. If you can wash these in cold water, diluting the borax powder first in hot water, allow it to cool enough, then add to the cold wash water for the scarf might be the best approach. Then as Tom said put the scarf in the sun to dry. Interesting that the Malessezia fungus is light sensitive.

Demodex cannot be cultured in a lab (they die in an hour or two when removed from the host). They have such short lives, your clothes are not going to be a source of re-infestation of live demodex -- but as above though, the eggs should be washed off in soapy water. 

As far as I know, no one knows how the long the eggs can survive, so to be certain, you can add a tiny amount of tee tree oil to the wash-cycle of your washing machine or wash basin -- rinse the TTO off completely so it doesn't stain your clothes (especially silk or wool), and you shouldn't have to worry.

Normal "good housekeeping" for washing your clothing is sufficient in my opinion. This is a variable idea though, as winter clothing worn next to the skin, like a scarf or gloves, will probably need more washing than most people would consider "normal." About every 2-3 weeks should be enough. The hood and collar of coat (assuming the coat can't be washed) is more problematic though, and you might douse the collar and cuffs in 91% isopropyl alcohol every 2-3 weeks, and let it air dry until there's no smell. Isopropanol dries extremely quickly in a dry, winter climate. Color-test isopropanol in an inconspicuous place to be sure it doesn't lift the dye, first.

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Logo of the Human Microbiome Project, a program of the NIH Common Fund, National Institutes of Health, image courtesy of Wikimedia Commons

This subject of microbiome-based therapeutic strategies for rosacea is one of my favorite subjects which I have done a great deal of research on. You may want to read the latest article I have written on this subject of the human microbiome. 

The GUT - BRAIN - SKIN axis has now been clearly established. 

Three Types of Gut Bacteria
They have now discovered that humans might be divided into three types of gut bacteria: Bacteroides, Prevotella and Ruminococcus, which may lead to personalizing medical treatment based upon which type gut microbes you predominantly have. "The three gut types can explain why the uptake of medicines and nutrients varies from person to person," [1] and may develop into a new ‘biological fingerprint’ on the same level as blood types and tissue types, akin to the 'blood type' diet and treatments. That is why probiotic treatment for rosacea is as valid, if not much better, as antibiotic treatment. 

Bacteroides
Bacteroides is a genus of Gram-negative, obligate anaerobic bacteria. Bacteroides species are non endospore-forming bacilli, and may be either motile or nonmotile, depending on the species. The DNA base composition is 40–48% GC. Unusual in bacterial organisms, Bacteroides membranes contain sphingolipids. They also contain meso-diaminopimelic acid in their peptidoglycan layer. Bacteroides species are normally mutualistic, making up the most substantial portion of the mammalian gastrointestinal microbiota, where they play a fundamental role in processing of complex molecules to simpler ones in the host intestine. As many as 1010–1011 cells per gram of human feces have been reported. They can use simple sugars when available; however, the main sources of energy for Bacteroides species in the gut are complex host-derived and plant glycans.[8] Studies indicate that long-term diet is strongly associated with the gut microbiome composition—those who eat plenty of protein and animal fats have predominantly Bacteroides bacteria, while for those who consume more carbohydrates the Prevotella species dominate.[2]

Prevotella
Prevotella is a genus of Gram-negative bacteria. Prevotella spp. are members of the oral, vaginal, and gut microbiota and are often recovered from anaerobic infections of the respiratory tract. These infections include aspiration pneumonia, lung abscess, pulmonary empyema, and chronic otitis media and sinusitis. They have been isolated from abscesses and burns in the vicinity of the mouth, bites, paronychia, urinary tract infection, brain abscesses, osteomyelitis, and bacteremia associated with upper respiratory tract infections. Prevotella spp. predominate in periodontal disease and periodontal abscesses. Research of human microbiota show that human gut is mainly inhabited by two phyla of bacteria – Firmicutes and Bacteroidetes, the latter mostly dominated by Bacteroides and Prevotella genera. Prevotella and Bacteroides are thought to have had a common ancestor. Formally, the two genera were differentiated in 1990. [3]

Ruminococcus
Ruminococcus is a genus of bacteria in the class Clostridia. They are anaerobic, Gram-positive gut microbes. One or more species in this genus are found in significant numbers in the intestines of humans. The type species is R. flavefaciens. As usual, bacteria taxonomy is in flux, with Clostridia being paraphyletic, and some erroneous members of Ruminococcus being reassigned to a new genus Blautia on the basis of 16S rRNA gene sequences. [4]

For more information: 
Do You Have A Gut Feeling About Your Rosacea?

End Notes

[1] What’s in your gut? Microbiota categories might help simplify personalized medicine
By Katherine Harmon | April 20, 2011, Scientific American

[2] Bacteroides, Wikipedia

[3] Prevotella, Wikipedia

[4] Ruminococcus, Wikipedia

A poster Facebook reported that Egg Whites applied topically on her rosacea works for her. 

If you try this treatment, please post in this thread your results.  

Dirk Bruere has a website where he has tried various formulas using DMSO with green tea, aspirin, alternating with a mixture of Copper Salicylate, Methyl Salicylate and Caffeine. He has tried other drugs/substances with DMSO which he lists that didn't work, and says he has totally cleared his rosacea for a good length of time. If you try this, please post your results in this thread. 

violentred26 at Reddit (scroll down to find her post) reports, "All I did was buy a big thing of 99% pure aloe Vera gel from Whole Foods (their brand) and a bottle of Jarrow Formulas Curcumin 95. I then opened one capsule of curcumin and dumped it into like two tablespoons of aloe (approximate, I didn’t measure). Then I spread the mixture all over my face and left on for 15 minutes. Oh, I also keep the aloe refrigerated so it’s nice and cold when I put it on. I did this mask once per day starting last Saturday through Tuesday, and I **** you not, it completely killed the rosacea flare up."

Mastic Gum Tears - image Wikimedia Commons

What is Mastic Gum?

costcogoldmember at Reddit reports, "Took Mastic Gum for four weeks and HCL supplement (still to this day). This was the best my skin has ever looked in four years and it cleared up within a couple weeks. It's now March 2019 and I have clear skin." If you try this, please post in this thread your results. 

Jarrow Mastic Gum.   Amazing Formulas     Betaine HCL.       Nutricost Betaine HCL
                                       Mastic Gum

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22 hours ago, kendraallen said:

sorry i don't try this recently i found the list of some best concealers in 2019 can you tell me what's your opinion ?? https://thefashionupdates.com/best-concealers/

Wish I could help but don't really know. You may want to know about Jamie Kern Lima, IT Cosmetics, who a rosacea sufferer. Our affiliate store carries some of her line of products. 

Rebound according to Medicine.net is "The production of increased negative symptoms when the effect of a drug has passed or the patient no longer responds to the drug. If a drug produces a rebound effect, the condition it was used to treat may come back even stronger when the drug is discontinued or loses effectiveness."  This can happen with any drug, but with rosacea the reports of rebound most often are with Mirvaso (Brimonidine) and to a lesser extent with Rhofade (Oxymetazoline Hydrochloride).

The RRDi began collecting negative anecdotal reports of Mirvaso Rebound and stopped at 242. 

Here are the positive anecdotal reports. 

Rhofade has less negative reports than Mirvaso. 

Both of these drugs are vasoconstrictors. You should be aware of this side effect or risk associated with these two drugs. 

However, it has been reported that those who use antibiotics for rosacea long term find that their rosacea returns rather quickly and is worse when antibiotic treatment is stopped, which is also a type of rebound.  

Rebound vs Allergic Reaction
 

The Daily Mail reports of an ex-model, Rebecca Morrison, who was able to stop her antibiotic treatment she was using for her rosacea and successfully used Kalme Day Defence SPF 25. Rebecca is reported to say, "I've now been using Kalme for a year and have been more or less free from all the symptoms for the majority of that time. Since using product I've seen almost 100 per cent improvement in my skin. I still get a few pimples now and then when I'm especially stressed and get a little flush if I'm out in the sun but zero flaking skin, painful irritation or furious redness! It has truly changed my life!"

Kalme Day Defence SPF 25 is sold in the United Kingdom and you can review the ingredients. 

Mother whose rosacea left her skin a 'furious' mess during pregnancy reveals she improved her skin in just four weeks WITHOUT medication - and it was all thanks to a £19.95 cream, By Chloe Morgan for MailOnline, Daily Mail  

Keep us posted on your progress. Taking probiotics (there is a lot of discussion on what brand to buy, but I think the main thing is your taking some kind of probiotic) along with Efracea can only help your gut and skin. I personally take bunch of vitamins and minerals. If you are interested in this subject, read this article on this FAQ:

Do Rosacea Sufferers have Nutritional Deficiencies?