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The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea.

J Cosmet Dermatol. 2018 Aug 11;:

Authors: Bageorgou F, Vasalou V, Tzanetakou V, Kontochristopoulos G

BACKGROUND: Erythematotelangiectatic rosasea is a common,chronic, relapsing disease characterized mainly by vascular components, for which many therapies may exist but with limited efficacy.
OBJECTIVES: We decided to test the efficacy of tranexamic acid when applied topically on the affected areas.Tranexamic acid is an antifibrinolytic,thus we considered it could be effective at this type of rosacea.
METHODS: This is an unblinded study. We included 20 patients, having erythematotelangiectatic rosacea. All patients were women between 27 and 65 years-old. We divided the patients in two groups,the first group was treated only with tranexamic acid solution (Transamin inj/sol 500 mg/5 mL) infused wet dressing for 20 minutes, and the second group was treated with microneedling simultaneously with tranexamic acid solution topical application followed by tranexamic acid solution infused dressing therapy,every 15 days for four sessions.
RESULTS: The improvement assecion was outlined according to the Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) and the use of clinical photos and dermoscopy. All patients were improved in the end of the therapy. There was statistically significant improvement, 2 units IGA-RSS in the first group, whereas 3 units IGA-RSS in the second group. The improvement lasted more than four months. The tolerability of the use of tranexamic acid was also asessed.
CONCLUSIONS: According to our results a new really promising simple, safe and cheap treatment option targeting mainly to the vascular net and the erythema of rosacea is proposed.

PMID: 30099833 [PubMed - as supplied by publisher]

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Another article: 

Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis

RRDi Post on TXA

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"A paste made from TXA tablets offers similar hemostatic benefits of topical IV TXA administration and provides another option for drug delivery. Pastes may be easier to apply to, and/or remain on, certain anatomic locations."

Trick of the Trade: Topical Tranexamic Acid Paste for Hemostasis, ALiEM

For more info about using TXA read this post

jrlhamcat2 writes about the TXA paste mentioned above, "They're crushing pills to make a paste to stop bleeding in emergency situations. That's a much stronger concentration that has been used topically for rosacea and seems potentially risky. A 3% or 5% solution will be a clear liquid."


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