Guide

“Rosacea’s one of my fortes. So rosacea and redness, it’s due to two things. One is histamine, too much histamine in your blood that causes you to flush and blush, and it could be due to triggers, foods that contain histamines or 5-HT, which is the precursor to histamine, which comes in things like eggplant, avocado, bananas. So if you eat that every day, don’t. Once in a while is okay, but not every day. And then other things that make you flush, like red wine or hot water." Macrene Alexiades, MD

The Dermatologist the Victoria's Secret Angels depend on gives us a lesson in skin, by LILITH HARDIE LUPICA, Skin, Vogue

Since rosacea makes skin sensitive and easily irritated, it’s important to do a small test on products to see how your skin reacts, says Dr. Wu. She suggests a patch test with new products. To do this, apply a small amount in front of your ear before bed. If there’s no redness or irritation when you wake up, apply it on the rest of your face. To seal in the most moisture, wash your face with lukewarm water (hot water can dry out your skin), then pat dry and apply your moisturizer. If your dermatologist has prescribed rosacea cream, apply the medicine first, wait a few minutes, then moisturize.

The Best Moisturizers for Rosacea, According to Dermatologists, By Kristin Canning, Health
How to treat rosacea at home with over-the-counter products recommended by skin doctors.

Dermatologists Recommended the Following Moisturizers in the above article: 

Fresh Rose Deep Hydration Face Cream

La Roche-Posay Effaclar Mat Oil-Free Facial Moisturizer for Oily Skin

Robin McGraw Revelation Hydra Qwench Moisturizing Night Cream

Clearogen Acne Lotion

SkinMedica Redness Relief Calmplex

Elta MD UV Elements Broad Spectrum SPF 44

Reply to this Topic

There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  

This common skin issue is caused by dilated blood vessels and increased blood flow. The rush of blood and extra pressure underneath the surface can also make the skin feel itchy, hot, and tingly. “As you get older, the collagen that surrounds your blood vessels, which helps them be strong, starts to wear down,” says Baumann. “After a while, your blood vessels lose that ability to shrink back down, so they stay dilated." While those with fair complexions typically notice the flush more, even those with darker skin tones can get rosacea.

Rosacea Treatment and Causes: How to Know When a Flushed Face Is Something More, By Jessica Cruel, Self

Blushing and Flushing Triggers

One of the physicians who serves on the RRDi Mac, Zoe Diana Draelos, MD, wrote, "Rosacea is probably a collection of many different diseases that are lumped together inappropriately." This statement is absolutely true. There are so many skin conditions that mimic rosacea that to differentiate them is quite the task for a dermatologist to accomplish. You may receive a diagnosis of rosacea but discover later you have a different skin condition/disease. Reports in RF have reflected such cases many times. The new phenotype diagnosis classification should improve diagnosis and treatment. A recent article reports the following: 

"Facial erythema (the "red face") is a straightforward clinical finding, and it is evident even to the untrained eye; however, a red face does not represent a single cutaneous entity. It may be due to a plethora of distinct underlying conditions of varying severity, including rosacea, demodicosis, dermatomyositis, lupus erythematosus, allergic contact dermatitis, drug-induced erythema, and emotional blushing. In clinical practice, dermatologists do not encounter only one type of facial erythema but rather a number of different shades of red. This review presents the clinical spectrum of facial erythemas and addresses the question of what lies beneath a red face by discussing the key clinical and histopathologic characteristics."

The "red face": Not always rosacea.
Clin Dermatol. 2017 Mar - Apr;35(2):201-206
Dessinioti C, Antoniou C

"One common complaint that patients have is skin redness," said Arisa Ortiz, M.D., director of Laser and Cosmetic Dermatology at UC San Diego Health. "The redness may be a result of dry skin or rosacea, a condition that causes flushing of the face. For people with mild forms of rosacea, nasal sprays like Afrin can temporarily reduce redness."

Medications with cosmetic benefits
March 9, 2017 by Jackie Carr, Medical Express

Microneedling with tranexamic acid solution was an effective treatment for women with erythematotelangiectatic rosacea, according to late-breaking research presented at the American Academy of Dermatology Annual Meeting.

Microneedling with tranexamic acid solution effectively treated rosacea, American Academy of Dermatology Meeting, Healio Dermatology

More info

RRDi Post on TXA

The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea.

Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis

Reply to this Topic

There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  

Here are the five famous rosaceans: 

Mariah Carey 
image courtesy of Wikipedia


William Arthur Philip Louis (Prince William)
image courtesy of Wikipedia


Cynthia Nixon
image courtesy of Wikipedia

Sam Smith
image courtesy of Wikipedia


Renée Zellweger
image courtesy of Wikipedia

Is rosacea the reason holding you back from doing the things you love? If yes, how about breaking its hold and starting all over again because you’re not alone.....which includes some famous celebrities too, who have been open about it? So, if rosacea couldn’t stop them from achieving great things in their life, then why would you want it to stop you from getting what you deserve?

Beauty: 5 Famous Faces Positively Living Through Rosacea, By Pauline Simons, INSCMagazine

Red Carpet, Red Face: Celebrities Talk About Their Rosacea, NRS

Famous Rosaceans

Another study published in Dermatology found a link between rosacea and anxiety and depression. Even those with mild flushing of the skin report negative psychological impacts, demonstrating the importance of a more in-depth medical evaluation to help design a treatment plan that addresses both physical and emotional symptoms.

How to manage your rosacea, BY DR. LESLIE BAUMANN, Miami Herald
 

"This connection between my own experience and relating to patients increased in my late 30s when I discovered I had rosacea. This causes severe redness and inflammation and can develop into acne-like spots, accompanied by a stinging, burning sensation."

Heal thyself: meet the doctors living with the conditions they treat, Health, The Guardian

"Morbihan syndrome is a rare entity that more commonly affects women in the third or fourth decade of life. It is considered a special form of rosacea and its pathogenesis is not fully known....According to most authors, it is a clinical variety of acne or rosacea, a common episodic chronic cutaneous disorder that affects the face. It is characterized by the permanent presence of erythema accompanied by telangiectasia, with frequent mixed facial flushing, papules, pustules, diffuse edema, and nodules." [1]

Rosacea Lymphedema (Morbihan Disease) is recognized as a rosacea variant. 

End Notes

{1] An Bras Dermatol. 2016 Sep-Oct; 91(5 Suppl 1): 157–159.
Morbihan syndrome: a case report and literature review
Rossana Cantanhede Farias de Vasconcelos, Natália Trefiglio Eid, Renata Trefiglio Eid, Fabíolla Sih Moriya, Bruna Backsmann Braga, and Alexandre Ozores Michalany

"According to AZoNetwork, a leading health care, life science online publisher in the U.K., the prevalence rate of rosacea is 1.65 per 1,000 person every year."

Persistent Facial Erythema Treatment Market driven by large research and development activities, Transparency Market Research, medGadget

On 2/15/2017 at 0:35 AM, Aidenwillson said:

I will share my experience. Before I started taking the drug I went online and looked at people's opinions. I noticed that there were several people who had reported problems with rebound flushing. I also noticed that in the clinical trial, the actual success rate compared to placebo was shockingly low. I am not a medical expert so I decided to shrug it off and take use the cream anyway.  My skin looked somewhat unnatural, kind of yellow, since there was no red in it. 

Besides the yellow, are you going to continue using it or have you stopped?

For the past two weeks have not used Soolantra, even though I have a half tube left and purchased a brand new refill for March. This should last me a while with Soolantra. My insurance would not cover the brand name sulphur cream my dermatologist gave me a Rx for. Called the doctor's office and the girl said there is no generic or other Rx to write for the sulphur prescription (I forgot to write down the brand name). I will be seeing the doc on March 8 for a follow up visit and ask him about it. So, I can either use my last jar of the ZZ cream or the Sulphur butter I have on hand. So far I have been using a little dab of Neosporin Bacitracin Zinc-Neoycin Sulfate-Polymyxin B Sulfate-Pramoxine HCL ointment on some of the red spots left over from the Soolantra. My skin is not burning anymore and it seems a lot healed. See for yourself. I plan on trying the Soolantra again but rarely to see if this keeps the pustules at bay. I am convinced I have nuked all the mites and now only need a little maintenance now and then with this regimen. I do think the Soolantra did actually clear up my face but using it every day is way too much. Maybe once a week or so should suffice, but time will tell. I will keep my regimen in this thread and post more photos. This forum is an excellent format for rosacea sufferers to post photos. We even have a gallery that each one could use and members can create their own blog.. Adding photos in the forum like this is easy. And if you are worried about posting your photos you can always cover the eyes with a black bar or something or worried about posting you name you can put up a fake display name and no one will ever know who you are. This post explains how to change your display name to a cryptic one and any concerns you have about privacy. Can you beat this format that IPS offers? I don't think so. So come on, Join the RRDi. 

"A diet low in vegetables and high in sugar-sweetened and diet soft drinks, refined sugars and carbohydrates, red and processed meats, and margarine has been linked to high levels of inflammatory markers in the blood, according to Michels...Our results suggest that a habitual diet that promotes chronic inflammation when consumed during adolescence or early adulthood may indeed increase the risk of breast cancer in younger women before menopause," said Michels."

Adolescent, early adult diet linked to chronic inflammation may increase premenopausal breast cancer risk
American Association for Cancer Research

There is growing evidence that a diet high in sugar/carbohydrate is a rosacea trigger. 

"Based on the clinical presentation, positive SSSB examination, and positive response to anti-Demodex therapy, we concluded this was a case of topical steroid induced-demodicosis."

Dermatol Pract Concept. 2017 Jan; 7(1): 35–38.
Published online 2017 Jan 31. doi:  10.5826/dpc.0701a06
PMCID: PMC5315038
Usefulness of dermoscopy in the diagnosis and monitoring treatment of demodicidosis
Paula Friedman, Emilia Cohen Sabban, and Horacio Cabo

Steve Bannon, White House Chief Strategist, is the subject of an article by Harry Shukman, The Tab, about his facial skin condition. 

"He's got blushing on the nose, which is generally the result of what is called rosacea. That's a pretty common disorder, maybe a third of the population has it. It can cause redness, and we don't really know why. We think it's because of proliferation of oil glands, sebaceous glands. It's a very common disorder.

A dermatologist explains what’s wrong with Steve Bannon’s haggard face, Harry Skukman, The Tab

image courtesy of Wikipedia

Famous Rosaceans

The research answers the following questions:

What are the key drugs marketed for Rosacea and their clinical attributes? How are they positioned in the Global Rosacea market?
What are the unit prices and annual treatment cost for Rosacea therapies in different countries? What are the drug pricing trends and how are they expected to change in the future? How are the drug pricing and reimbursement landscape different by countries?
What are the unmet needs in the global Rosacea drugs market? What would be the ideal pricing strategy for a new pipeline therapy for Rosacea?

Rosacea Drugs Price Analysis and Strategies 2012-2016 & Forecasts to 2021 - Research and Markets, PR Newswire

"Before my treatment, I assumed that laser procedures were going to be part of my beauty regimen way down the line, not when I'm in my early 20s. But according to Graceanne Svendsen, the aesthetician who performed my procedure, lasers are becoming increasingly popular with women in their 20s, particularly those who deal with skin conditions such as rosacea or general unevenness."

I Tried Laser Treatment To Help With My Rosacea & I Was Amazed With The Results — PHOTOS, By JESSICA THOMAS, Bustle

"A recent study in the British Journal of Dermatology makes a case for treating and managing rosacea based on the clinical presentation, or phenotype....The international ROSCO panel was able to reach a consensus on initial, combination, and maintenance therapy using a phenotype-based approach for treating skin features of rosacea. Ophthalmologists on the panel also agreed on an approach to managing ocular rosacea. Results suggest that physicians should select a combination of treatments for rosacea based on presenting features, overall disease activity, and the severity of the features."

Global Consensus on Rosacea Treatments by Phenotype, by Jennifer Newton, Clinical Trials and Research, Medical News Bulletin

“This nationwide cohort study provided evidence of an association between rosacea and incident IBD,” the researchers concluded. “The link between long-term antibiotic use and development of IBD needs further investigation.”  – by Bruce Thiel. Healio Dermatology

Rosacea may be tied to increased risk for inflammatory bowel disease
Wu C-Y, et al. J Am Acad Dermatol. 2017;doi:10.1016/j.jaad.2016.11.065.

A recent study says sugar weakens MIF (Macrophage migration inhibitory factor) 

"Macrophage migration inhibitory factor (MIF or MMIF), also known as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase is a protein that in humans is encoded by the MIF gene. MIF is an important regulator of innate immunity." Wikipedia

"The study says blood sugar glucose and the neurological condition has close connections. Glucose weakens the key enzyme called MIF, or macrophage migration inhibitory factor that resists the spread of the disease...Regarding the most vulnerable people, the study says higher risk prevails for people who are obese and diabetic as they have high levels of blood sugar, or hyperglycemia. This leads to the accumulation of abnormal proteins in the brain.....In the next level of research, they study team will examine whether similar changes are happening in the blood as well, added Van den Elsen."

Here's Why Using More Sugar May Cause Alzheimer's Disease, By Kalyan Kumar, Tech Times 

With the current theory that rosacea may be an immune system disorder, can you see the connection between Sugar and Rosacea?

"And if the machine shows rosacea what would you recommend for that? I heard there is a new cream on the market that works well." Kristin Auble

"Yes, it’s called Rhofade and it just received FDA approval. So that’s exciting. We also have a laser called the Vbeam that helps with vascular issue such as rosacea. So I would recommend a combo of the cream and laser treatment." Dr. David Shafer, New York City

Tech Alert: 3D Imaging May Be The Secret to Perfect Skin, by Kristin Auble, W Magazine

Dermata Therapeutics, a San Diego development-stage biotech advancing new treatments for rosacea, eczema, and related dermatological diseases, said it has secured $5 million in additional funding from private investors and entered into a $5 million credit facility with Silicon Valley Bank. Dermata has developed DMT210 which is for rosacea. 

Dermata Secures $10M in Combined Financing for Skin Treatments, by Bruce V Bigelow, Xconomy, San Diego

The Dermatologist Forms Collaboration with The National Rosacea Society, PRWeb, Benzinga