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  1. The answer to the question is to social media platforms. 

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    This post is about rosacea and social media platforms where all the rosaceans have gone and is an in-depth deep dive into this subject. Before we look at some of the data on this it would be good to go back in time and look at the history of the internet and rosacea, before the advent of social media.  

    Sixteen years ago when the RRDi was founded by rosacea sufferers with the motive to form a grassroots patient advocacy group that could have a united voice to the medical community who at that time didn’t take any rosacea patient advocacy group for rosacea seriously because none existed. Does the medical community take seriously a united effort from any social media platform group on rosacea that is a grassroots patient advocacy group?  I will let you think about that question. 

    There were two such organizations formed in 2004, one by David Pascoe (and others) and the other, the RRDi which involved myself (and others) who split into two camps. David Pascoe opted to using an html website for his non profit organization for rosacea and we opted for the Invision Power Board platform. David’s non profit, the Rosacea Research Foundation, was a similar grassroots organization that was more popular, raising $16K in a very short time and then quickly disbanded by the end of 2005, donating the entire money raised to the NRS, which was ironic, since both the RRDi and the RRF were formed because rosaceans wanted their own grassroots organization and were not happy with the NRS and its organization, how it was spending its donations, mostly on private contractors owned by one of the NRS board members, and very little on rosacea research.  But the glimmer of hope is that the RRF shows what can be done with a grassroots patient advocacy non profit organization. 

    RRF-Cheque1.jpgRRF-Cheque2.jpg

    The RRDi software platform was Invision Power Board which evolved into the Invision Community.

    IP>IPS>IC.png

    The forum platform software was extremely popular back in 2004 and is still used today by many organizations and companies. 

    forumsoftware.png

    The RRDi eventually hosted the entire website and forum on Invision Community servers. The RRDi continued to grow with members (1.3K) and small donations and over the course of almost seventeen years we have received around $15.5K which is around $900/year in donations. We did spend about $6K on education grants sponsored by Galderma and the rest spent to keep the website going and legally continue as a non profit with registration fees and published one edition of our print on demand journal. It does cost money to keep a non profit organization going, even if no one is receiving a salary, no employees and no payments to private contractors owned by one of the board members. We don’t do that. Everyone is a volunteer. Pro bono. 

    Then over the years the members and posts have dropped to nearly zero. We know we have traffic to our website because Google Analytics shows we do, nearly 4K visit our website each month, but they do not engage. So what happened? Where have all the rosaceans gone?  Back in 2004 there were many volunteers and they were working hard to create a grassroots, rosacea patient advocacy non profit organization. Where are they now?

    Around the same time the RRDi was formed, Zuckerberg began Facebook, a social media and social networking service, with a different but similar platform as the ‘forum’ style platform and Facebook took off and exceeded all expectations and became the number one social platform. Others followed, i.e., Instagram, Twitter, Reddit and that list goes on. 

    According to Search Engine Journal, in 2020 Facebook has 2.45 billion users, Instagram 1 billion users, Reddit 430 million, Snapchat 360 million, Twitter 330 million users, Pinterest 320 million, LinkedIn 310 million. So let's analyze where the rosaceans are on these social media platforms and what they are doing. 

    facebook.png

    When you do a rosacea search on Facebook you can find where rosaceans have gone. The number one Facebook that comes up is the NRS with nearly 40K friends and 41K followers. 
    NRSFacebook.png

    This non profit organization for rosacea has spent 10% of its donations on rosacea research over a twenty year period. 60% of the donations are spent on two private contractors owned by one of the board members. The Board Members of this Non Profit Organization are NOT rosaceans, and are comprised of businessmen (three), dermatologists (two), one RN, and a medical editor. For More Information. This non profit is heavily sponsored by pharmaceutical companies which is shown on its website if you scroll towards the bottom you will see the following:

    NRSsponsors.png
    While this Facebook group is the most popular, do you consider this a grassroots patient advocacy group for rosacea or something else?

     

     

    RSGFacebook.pngRSGfollow.png

    As far as known, the Rosacea Support Group is the next largest Facebook group with 15K followers and 14K likes. It states clearly that this is a non profit organization but there is absolutely no evidence that RSG is registered as non profit. This is David Pascoe's group and his website is making money because there are affiliate links and sponsors for rosacea treatments but there is no evidence that this group engages in any rosacea research or has any influence on the medical community. 

    rosaceafacts.png

    RosaceaFacts on Facebook has 18K followers and likes and is run by the pharmaceutical company Galderma. 

    rosaceaspanish.png

    The Rosacea Spanish Facebook has 6K followers and nearly 6K likes. 

    rosaceaawareness.png

    Rosacea Awareness says it is an actual 'community' and the official link is to StudyKIK.com which is a site for clinical trials. The about page at StudyKik says, "StudyKIK is the leading website where clinical trial companies list their studies and eager volunteers find them to sign up instantly." The Facebook ABOUT page doesn't explain who is running it but on the MORE INFORMATION link at the bottom of the page it links to its Instagram page that doesn't explain who this Facebook account belongs to but obviously it is somehow connected to StudyKik who say they are 'volunteers.' Nevertheless, 5.5K follow and like this Facebook Group. Do you think this social media 'community' has any influence on the medical community as a voice for rosaceans?  

    If you know of any other rosacea Facebook groups which should be in this list, please find the reply button and let us know. 

    instagram.png

    While there are rosaceans obviously on Instagram, figuring out which one is the most popular is difficult to say the least. Some of the ones who come up in the search box are #rosacea, #rosácea, #rosaceatreatment,  #rosaceaskincare, and this list goes on and on. For example, the NRS has an account shown below: 

    NRSinstagram.png

    As previously mentioned about the NRS Facebook group and how this non profit represents businessmen and dermatologists who are the voice behind this organization and is not run by rosacea sufferers, apparently, the NRS Instagram isn't as popular with posts and followers as its Facebook group is.  If you know of an Instagram account that is more popular that should be mentioned, please find the reply button and let us know. There are rosaceans at Instagram but are any accounts representing rosacea sufferers as a united group that influences the medical community about rosacea? 

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    Reddit appears to be the more popular social media website for rosaceans. There are 'subreddits' that are specifically made up of rosaceans while there are other subreddits that discuss rosacea, i.e., r/SkincareAddiction (1.2m members), r/30PlusSkinCare (124K members), r/medical (63.8K members), r/Accutane (29.6K members), r/AusSkincare (27K members) and others but we will mention one rosacea subreddit below: 

    reddit_r:rosacea.png

    You can see the number of members above in this subreddit and now lets try to figure out who runs this? Note below the results: 

    reddit_moderators.png

     

    Does this give you an idea of who is running this huge subreddit?  Is this a registered non profit organization? Is it run by businessmen or medical professionals? What credentials are behind the moderators?  Why do they hide behind cryptic display names?  This gives you an idea of where the rosaceans have gone and rosaceans love it this way, behind cryptic display names. Do you think that this subreddit rosacea group with 21K members have any influence on the medical community to find the cure for rosacea or engage in any rosacea research?  

    snapchat.png

     

    Are there rosaceans on snapchat?  Did a search on 'stories' and got this result: 

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    Did a google search with no results either. So if you know if there are rosacea sufferers on snapchat, can you please find the reply button to this post and tell us what you know. 

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    Did a search on twitter with 'rosacea' and all sorts of 'tweets' come up but there isn't any one post that shows a united effort for rosaceans to come together into one cohesive patient advocacy group. Searched the 'National Rosacea Society' and discovered it has 3201 followers and 563 following on December 1, 2020  (which we mentioned about in Facebook and Instagram). Doesn't appear that there is any attempt with rosaceans to unite with twitter into one large group with a 'voice.' 

    pinterest.png
    Did a search on Pinterest using the 'board' as the choice and got a number of 'boards' shown below or you can see for yourself by clicking here

    pinterestboards.png

    The first one on the top left is Talonted Lex, a beauty blogger, who has rosacea and on Pinterest has 9.5K followers. The second one on the top row from the left is May Lindstrom Skin who has a  'lifelong battle with severe eczema and perioral dermatitis' with 2.6K followers at  Pinterest. The third one from the left top row is Clare Baucom who doesn't explain who she is but has 1.9K followers on her 'Rosacea Sensitive Skincare' and lots of over the counter treatments. This keeps on going but most of the 'boards' are selling over the counter treatments for rosacea. Do you know of any 'board' at Pinterest that is the voice of all rosacea sufferers in a patient advocacy united group that the medical community listens to?  

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    Did a search on LinkedIn and not much happening with rosaceans at this social media business connection site. Professor Tony Chu started a charity named the The Acne & Rosacea Association UK with 57 members. Rosacea Care, who offers treatments for rosacea, is also listed. PCA who also offers treatments for rosacea is listed with 600 members. Not much happening with rosacea patient advocacy movements at LinkedIn. 

    Conclusion

    This is an in-depth look done in December 2020 searching where all the rosaceans have gone and they are happy posting in the above social media groups and could care less if there is any movement to create a grassroots rosacea patient advocacy group like the RRDi. So if you are happy with what is currently happening with where all the rosaceans have gone, good for you.

     


     


     

     

     

  2. botox-cosmetic-100-units-vial.jpg

    "Patients with rosacea have elevated levels of cathelicidin and elevated levels of stratum corneum tryptic enzymes (SCTEs). Cathelicidin is cleaved into the antimicrobial peptide LL-37 by both kallikrein 5 and kallikrein 7 serine proteases. Excessive production of LL-37 is suspected to be a contributing cause in all subtypes of Rosacea. Antibiotics have been used in the past to treat rosacea, but antibiotics may only work because they inhibit some SCTEs." [1]

    "In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers...These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study." [2]

    Botox has been used to treat rosacea for some time now. [3]

    End Notes

    [1] Cathlecidin, Wikipedia 

    [2] J Dermatol Sci. 2019 Jan; 93(1): 58–64.Author manuscript; available in PMC 2020 Nov 22.
    Botulinum toxin blocks mast cells and prevents rosacea like inflammation
    Jae Eun Choi, MD, Tyler Werbel, MS, Zhenping Wang, PhD, Chia Chi Wu, BS, Tony L. Yaksh, PhD, and Anna Di Nardo, MD, PhD

    [3] Botox for Rosacea

    Et cetera 

    Cathlecidin

    Cathelicidin Peptide LL-37 and Vitamin D3

    Hydroxychloroquine Suppresses LL37-induced Mast Cells

    Alarmins, Vitamin D, And Other Info

     

  3. "Arthralgia and myalgia had the same percentage as reported by the control group and in normal populations; however, Raynaud's phenomenon was slightly greater than reported in the 2 control group and the general populations. There could be an inverse relationship between Raynaud's treatment with vasodilators and rosacea flushing symptom."
    A Clinico-Pathological Investigation of Rosacea with Particular Regard to Systemic Diseases, Dr. Mustafa Hassan Marai

  4. We are compiling a list of arachnicide treatments for rosacea. If you have one we missed, please reply to this post. That is what volunteering is all about, helping other rosaceans find information to treat and ultimately cure rosacea. 

    Arachnicide Treatments for Rosacea

    Anti-Parasitic Prescription Agents for Rosacea

    Azelaic Acid

    Benzyl Benzoate

    Borax

    Crotamiton

    Demodex Solutions

    Diatomaceous earth

    IPL

    Ivermectin 

    Oral Ivermectin and Metronidazole

    Ornidazole tablets (500 mg twice a day) and recombinant bovine basic fibroblast growth factor gel (0.2 g/cm twice a day) for an 8-week period (4th post by J Rush)

    Over the Counter

    Permethrin

    Praziquantel

    Sulphur (sulfur)

    Tea Tree Oil

    ZZ Cream

  5. 213px-Raynaud_syndrome_on_female_airman's_hand.jpg

    Raynaud syndrome on female airman's hand image courtesy of Wikimedia Commons

    Eilleen66 [post no 5] points out at RF, "I was pointing out the coincidence that a lot of people who have rosacea also have Raynauds type symptoms."  So I thought I would do a little research on this using the search tool here at the RRDi website by simply typing in 'Raynaud' and see what comes up. Didn't do a Google search, since that takes more time and effort. Are you up to the task of really investigating this subject, googling it, and then add to this thread?  Not many are really into doing rosacea research but would rather 'rely on social media groups' to 'help them deal with this disease' [rosacea]. If you do find some point related to this subject, wouldn't it be incredible if you volunteered to post your search results in this thread to help other rosaceans who may be searching this same subject?  Be sure to rely on social media groups for your information as most rosaceans do instead of published clinical papers in medical journals. Just kidding. 

    First off, while exposure to heat and cold is listed on most rosacea trigger lists, i.e., the NRS trigger factor list, there hasn't really been any clinical papers on this subject, as far as known, with double blind, placebo controlled, peer reviewed studies. Also it is not established in any known papers that a lot of rosaceans have Raynaud type symptoms. There are some papers that says 'some' rosaceans have Raynaud syndrome. Wouldn't it be nice to know in a huge study of say 2000 rosaceans what percentage have Raynaud syndrome?  Who would pay for such a study?

    Wouldn't it be incredible if a rosacea patient advocacy group like the RRDi got 10K members together who all agreed that this should be investigated whether 'a lot of rosaceans have Raynaud type symptoms' and decided they wanted this investigated with an actual double blind, placebo controlled peer reviewed clinical study. If 10K members each gave ONE DOLLAR and everyone agreed this should be done, do you think we could offer this money to some worthy, reputable clinician to actually investigate this subject, i.e., possibly one of the RRDi MAC members or some other reputable authority?

    So what are the results of my search using the RRDi search tool on our website? Note below my results with bold added for emphasis: 

    "A notably high percentage of patients had neurologic (43% [6 of 14]) or neuropsychiatric (50% [7 of 14]) conditions, including complex regional pain syndrome, essential tremor, depression, and obsessive-compulsive disorder. Neurovascular disorders, including headaches (71% [10 of 14]) and Raynaud phenomenon (29% [4 of 14]), as well as rheumatologic disorders (36% [5 of 14]), including lupus, rheumatoid arthritis, fibromyalgia, mixed connective tissue disease, and psoriatic arthritis, were also common." Neurogenic Rosacea

    "There is a clear subset of patients seen by both neurologists and dermatologists, whose main complaints are facial pain and dysesthesias. These patients often have a history of prominent facial flushing and blushing in response to various stimuli such as emotional stress, hot beverages, alcohol, spicy foods, exercise, heat, and sun exposure. They may also have erythematous papules and pustules. This cluster of features is most consistent with a diagnosis of rosacea but, when combined with the pain and dysesthesias, a form of complex regional pain syndrome must also be considered. In addition, some patients may have concurrent erythromelalgia and Raynaud's disease, suggesting that the etiology is perhaps more complex." Neuropathic Rosacea

    "The role of Helicobacter pylori (HP) in some digestive diseases (gastritis, ulcer, gastric cancer, MALT lymphoma) is well known. It has been suggested relatively recently that infection with HP can be involved in various extra-digestive conditions: respiratory disorders (chronic obstructive pulmonary disease, bronchiectasis, lung cancer, pulmonary tuberculosis, bronchial asthma); vascular disorders (ischaemic heart disease, stroke, primary Raynaud phenomena, primary headache); autoimmune disorders (Sjogren syndrome, Henoch-Schonlein purpura, autoimmune thrombocytopenia, autoimmune thyroiditis, Parkinson's disease, idiopathic chronic urticaria, rosacea, alopecia areata); other disorders (iron deficiency anaemia, growth retardations, liver cirrhosis). Case studies, small patient series and non-randomized trials that have shown a beneficial effect of HP eradication in different conditions are not convincing."
    Extragastric manifestations of Helicobacter pylori infection.

    "Biofeedback can improve cutaneous problems that have an autonomic nervous system component. Examples include biofeedback of galvanic skin resistance (GSR) for hyperhidrosis and biofeedback of skin temperature for Raynaud's disease."
    Biofeedback, cognitive-behavioral methods, and hypnosis in dermatology: is it all in your mind?

    "In the capillaroscopic examination in all patients with rosacea atypical capillaries were found. The abnormal capillaries were present in 10 volunteers (63%). In the rosacea group the most common occurred: Raynaud loops in 10 cases (62.5%), meandering capillaries and their elongation also in 10 patients (62.5%) and increasing number of the capillaries in 13 examined persons (81.25%). In the control group the presence of stenosed capillaries was confirmed in 3 examined persons (18.75%) with good visualized subpapillary venous plexus also in 3 cases (18.75%)."
    Assessment of microcirculatory system with conventional capillaroscopy in patients with rosacea--preliminary study

    "Mirvaso gel should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans, scleroderma, or Sjögrens syndrome. Alpha-2 adrenergic agents can lower blood pressure."
    FDA OKs Topical Gel to Take Red Out of Rosacea - (Mirvaso)

    "Use with caution in patients with cerebral or coronary insufficiency, Raynaud’s phenomenon, thromboangiitis obliterans, scleroderma, or Sjögren’s syndrome and advise patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop.' Warning About Using Rhofade With Cardiovascular Disease

  6. On report on this subject states, "the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated."

    Int J Mol Sci. 2020 Nov 10;21(22):
    Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut-Brain-Skin Axis.
    Woo YR, Han YJ, Kim HS, Cho SH, Lee JD

  7. clinical_reset.png

    Clinical Reset by CelleRx according to the manufacturer is "A powerful daily mist, Clinical Reset’s hero ingredient; Hypochlorous Acid (HOCl), eradicates the leading causes of redness, irritation and skin damage without stripping the skin. Part of your immune system’s natural response, HOCl is a naturally occurring compound produced by your white blood cells to fight trauma and infection." 

    Cost: $54 at this page.
    Ingredients:

    Pure hypochlorous acid, .01% as a preservative in saline.

    What is hypochlorous acid?

    "In a recent study, a saline hygiene solution preserved with pure hypochlorous acid was shown to reduce the bacterial load significantly without altering the diversity of bacterial species on the eyelids. After 20 minutes of treatment, there was >99% reduction of the Staphylococci bacteria."

    Stroman, D. W; Mintun, K; Epstein, A. B; Brimer, C. M; Patel, C. R; Branch, J. D; Najafi-Tagol, K (2017). "Reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin". Clinical Ophthalmology. 11: 707–714. doi:10.2147/OPTH.S132851. PMC 5402722. PMID 28458509.

    Cool video showing the spray mist: 

    There are some less expensive hypochlorous sprays for your consideration mentioned in the next post. 

  8. zilxi-rosacea-canister.png.1a65bde7f5170

    Now available announced by Vyne Therapeutics. Ask your dermatologist. Post your experience in this thread. Find the reply button. 

    vynetheraputics.jpg.a74b9ada77850fd88b18

    "The Company also announced that the annual list price of ZILXI will be $485 per 30-gram canister, in parity with the wholesale price of AMZEEQ® (minocycline) topical foam, 4%, the Company's topical minocycline indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in adults and pediatric patients 9 years of age and older." 
    PR Newswire Association LLC. All Rights Reserved. A Cision company

    We have been following minocycline topicals for rosacea for some time now. For more information

  9. astion.png

    Dermadexin (also known as Pruridexin or Helioclin® Dermatitis SD Cream) is a topical treatment for dermatitis and seborrhoeic dermatitis developed by Astion Pharma with a unique mechanism of action using a Fatty acid amide hydrolase (FAAH) inhibitor and a NF-kappa B (NF-kB) inhibitor designated as pyridine-3-carboxamide glyceryl monocaprylate (P3CGM), which has an excellent topical safety profile demonstrating a broad range in pre-clinical studies. [1]

    It was announced in August 2015 that the FDA accepted 510(k) submission for Dermadexin. [2]

    There is now available an over the counter topical, Astion Face Cure (active ingredient Dermadexin), available at Amazon UK or on the Astion Pharma website.  

    30g-Face-Cure.jpg

    Astion Face Cure contains the active ingredient Dermadexin [Pruridexin] and the inactive ingredients water, liquid paraffin, cetostearyl alcohol, glycerol, niacinamide, sodium cetostearyl sulphate, glyceryl monocaprylate and benzyl alcohol. 

    Anecdotal Reports 

    There are at least a couple of positive reports of using the Astion Face Cure, Boris started a thread on this, and post no 141 by freixinet

    End Notes 

    [1] Dermadexin Executive Summary

    [2] FDA Accepts Dermadexin 510(k) Submission, Aug 6th, 2015, Medesthetics

  10. While there are reports of successfully using isotretinoin for rosacea that are positive, there are also negative reports like this one. The video below by Leginairerpg is discussing high dose isotretinoin and is NOT discussing low dose isotretinoin which is one of the current state of the art 'off label' treatments for rosacea. 

    Video by Legionnairerpg

    About: This video deals with the effects of ROACCUTANE. If you have spots, don't take this drug, it's the worst you can do for your mind and your body. I m a french victim of this "medic", i fight now for the truth.

    Read the comments how controversial this drug has become (at high doses).

    Watch Accutane Experiences on YouTube

  11. "Inflammatory conditions such as rosacea, granuloma annulare, and hidradenitis suppurativa benefit from lower oral isotretinoin dosage of 0.3-1 mg/kg/day, whereas, hyperkeratotic diseases such as psoriasis and pityriasis rubra pilaris, consistently respond better to higher dosages of up to 2-4 mg/kg/day for lesion clearance."

    Arch Dermatol Res. 2020 Nov 05;:
    Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
    Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA

  12. finacea15foam.png

    "Azelaic acid 15% foam used off-label might be a useful treatment or adjunctive therapy for folliculitis." [1]

    "Off-label prescribing is when a physician gives you a drug that the U.S. Food and Drug Administration (FDA) has approved to treat a condition different than your condition. This practice is legal and common. In fact, one in five prescriptions written today are for off-label use." [2]

    In one clinical trial using azelaic acid for demodectic folliculitis it states, "The purpose of this study is to measure the effects of azelaic acid on Demodex folliculorum counts and disease condition via a split face design in approximately twenty patients with mild to moderate rosacea. The investigators hypothesize that treatment of rosacea with azelaic acid will lead to a decreased Demodex folliculorum count as well as an improvement in lesion count and redness." [3]

    More information on Azelaic Acid (for rosacea)

    finaceafoambox.jpg

    End Notes

    [1]J Clin Aesthet Dermatol. 2020 Apr; 13(4): 36–38.
    Examining 15% Azelaic Acid Foam for the Treatment of Folliculitis: A Pilot Study
    Zoe Diana Draelos, MD

    [2] Off-Label Drugs: What You Need to Know, Agency for Healthcare Research and Quality, An official website of the Department of Health and Human Services

    [3] zelaic Acid on Demodex Counts in Rosacea, ClinicalTrials.gov Identifier: NCT03035955

  13. "Of note, the data available so far suggest that therapeutic efficacy of HCQ in COVID-19 is well overshadowed by its ineffectiveness and detrimental effects as shown by some of the above-referred studies. Therefore, it is suggested to avoid use of HCQ for COVID-19 patients (unless necessary) until clear, sufficient, well-conducted, randomized, and controlled clinical data is available to reach the right conclusions."

    logo-frontpharmacol.gif.3f7222b175dee147

    Front Pharmacol. 2020; 11: 582025.
    Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines
    Rajnish Kumar, Janmejai Kumar Srivastava,  Rachana Singh,  Mohammed Haris Siddiqui,  Rasha A. Mansouri,  Jawaher A. Abdulhakim,  May N. Bin-Jumah,  Saad Alkahtani,  Mohamed M. Abdel-Daim,  Md. Sahab Uddin

  14. "Till date, chloroquine is verified effective against COVID-19 in vitro through influencing bis (monoacylglycero) phosphate entry by controlling the endocytic pathway (Carrière et al., 2020). The use of chloroquine against COVID-19 might be a risk and require continuous monitoring until confirmed clinical evidence are available."

    logo-frontpharmacol.gif.3f7222b175dee147

    Front Pharmacol. 2020; 11: 582025.
    Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines
    Rajnish Kumar, Janmejai Kumar Srivastava,  Rachana Singh,  Mohammed Haris Siddiqui,  Rasha A. Mansouri,  Jawaher A. Abdulhakim,  May N. Bin-Jumah,  Saad Alkahtani,  Mohamed M. Abdel-Daim,  Md. Sahab Uddin

  15. "One of the recent in vitro studies conducted by Clay et al. (2020) confirmed the antiviral activity of ivermectin against SARS-CoV-2. The SARS-CoV-2 infected Vero/hSLAM cells were subjected to 5 µM ivermectin for 48 h. The study indicates about 5,000-fold decrease in viral RNA as compared to the control. This was the first study to assess and demonstrate the effectiveness of ivermectin in COVID-19."

    logo-frontpharmacol.gif

    Front Pharmacol. 2020; 11: 582025.
    Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines
    Rajnish Kumar, Janmejai Kumar Srivastava,  Rachana Singh,  Mohammed Haris Siddiqui,  Rasha A. Mansouri,  Jawaher A. Abdulhakim,  May N. Bin-Jumah,  Saad Alkahtani,  Mohamed M. Abdel-Daim,  Md. Sahab Uddin

  16. "These findings demonstrate the broad‐spectrum antiviral property of ivermectin benefiting for COVID‐19 treatment in the context of predictive, preventive, and personalized medicine in virus‐related diseases."

    J Cell Physiol. 2020 Sep 22 : 10.1002/jcp.30055. doi: 10.1002/jcp.30055 [Epub ahead of print]
    Quantitative proteomics reveals a broad‐spectrum antiviral property of ivermectin, benefiting for COVID‐19 treatment
    Na Li, Lingfeng Zhao,  Xianquan Zhan

    "Close to 70 clinical trials are currently in progress worldwide for SARS-CoV-2. Although few of these studies have been completed, the results that are available, as well as those from observational/retrospective studies, indicate clinical benefit. Here we discuss the case for ivermectin as a host-directed broad-spectrum antiviral agent, including for SARS-CoV-2."

    Biochem Biophys Res Commun. 2020 Oct 21 doi: 10.1016/j.bbrc.2020.10.042 
    The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2?
    David A. Jansa, Kylie M. Wagstaffb

  17. invisionlogo.png.857e16c6cd5f5c76b2661ee

    The RRDi has been using Invision Community forum platform since 2004. When we started in 2004 it was recommended by Warren Stuart who was the assistant director of the RRDi to use what was then called Invision Power Services (later the name was changed to Invision Community). It is a powerful platform with many add-on features and a significant number of developers adding plugins and additional features to the platform. However, with the advent of mobile devices and social media platforms the trend has focused on mobile apps using iOS and Android devices found in the Apple App Store and Google Play Store. The popularity of using these apps over using a browser to view a website has increased the use of social media platforms such as Reddit, Facebook, Instagram, Twitter, etc. The developers and owners of the Invision Community platform have now announced beta versions of iOS and Android apps for their platform which has been embedded for years using only a web browser, so we have announced with this post here asking for volunteers to download the beta versions and help test these new apps. Please consider volunteering and using these beta versions of the apps. 

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    Invision Community Clients

    There are some significant clients who use Invision Community as their platform which you can see below: 

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    Medical Clients Who Use Invision Community Platform

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  18. artificialsugardrink.png*

    Artificially Sweetened Drinks

    "Records for 104,760 participants were included....Artificially sweetened beverages were defined as those containing non-nutritive sweeteners. Sugary drinks consisted of all beverages containing 5% or more sugar....Researchers looked at first incident cases of cardiovascular disease during follow-up from 2009-2019, which were defined as stroke, transient ischemic attack, myocardial infarction, acute coronary syndrome and angioplasty. After excluding the first three years of follow-up to account for potential reverse causality bias, 1,379 participants had first incident cases of cardiovascular disease. Compared to non-consumers, both higher consumers of sugary drinks and of artificially sweetened beverages had higher risks of first incident cardiovascular disease, after taking into account a wide range of confounding factors..."

    Artificially sweetened drinks may not be heart healthier than sugary drinks, Medical Xpress, October 27, 2020, research letter in the Journal of the American College of Cardiology

    Sugar Any Better?

    "Drinking one or more sugary beverages a day was associated with a nearly 20% greater likelihood of women having a cardiovascular disease compared to women who rarely or never drank sugary beverages, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association."

    California study finds drinking sugary drinks daily may be linked to higher risk of CVD in women, Medical Xpress, May 13, 2020, by American Heart Association

    Research on Sugar Beverages Triggering Rosacea

    Do you think it is possible for a non profit organization for rosacea get its members to each donate one dollar to investigate whether or not sugar beverages or artificially sweetened drinks are a rosacea trigger in a double blind, placebo controlled, peer reviewed clinical study? It would take approximately 10K members to do this if the members wanted this. What do you think? Have you noticed whether drinking a sugar beverage triggers your rosacea?

    *Image credit CCO public domain

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