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  1. Noticed a couple of posts that nappy, [aka, diaper] (Australian English and British English), skin treatments are helpful in some cases. For example a post from Smacky at RF who reports, "I've been using Bepanthen for about a week now....So I tried Bepanthen, and within a few hours noticed the skin on my nose and cheeks had settled down a bit and looked better. I've been applying it every morning and night before bed, and every day this week I've woken up find my nose a little less red than the day before. I also haven't had a single new spot or lump. I woke up today and looked in the mirror and my nose is the same skin tone as my face. It's almost surreal. Its like looking at a different person who I'd forgotten about. I feel wonderful  Anyway I really hope this will help someone else."

    71WkdDw5PpL._SX522_.jpg.d5d65fd01ab7a7ac

    Ingredients in Bepanthen:
    Aqua, Lanolin, Paraffinum liquidum, Petrolatum, Panthenol, Prunus amygdalus dulcis oil, Cera alba, Cetyl alcohol, Stearyl alcohol, Ozokerite, Glyceryl oleate, Lanolin alcohol.

    Rubydo1 post no 2 states about this SD/Rosacea, "To be honest if it wasn’t for sudocrem I’d have a lot more spots." Sudocrem is a product made in Ireland which is available at Walmart.

    sudocrem.png

    The ingredients for Sudocrem: 
    Zinc Oxide Ph. Eur., Benzyl Alcohol B.P., Benzyl Benzoate B.P., Benzyl Cinnamate, Lanolin, Purified Water, Liquid Paraffin, Paraffin wax, Beeswax, Micrcocrystalline wax, Sodium Benzoate, Linayl Acetate, Propylene Glycol, Citric Acid, Butylated Hydroxyanisole, Sorbitan Sesquioleate, Lavender fragrance 

    Ingredients for Dermocrem are similar: 

    4cdaa1bd-79a6-4503-9c55-78fd5eebe121_1.7

    5a5d56d3a27d3_81naOVlFWL._SX522_.jpg.1b1

    A similar product that is also used to treat diaper rash is Rugby Zinc Oxide Ointment with the following ingredients: 
    Active ingredient
    Zinc oxide 20%
    Inactive ingredients
    mineral oil, petrolatum

     


  2. plewig.jpg
    Gerd Plewig, MD, who volunteers on the RRDi MAC recently sent a message to all the RRDi members about his fourth edition of his classic book on acne and rosacea which we feature in our store. Below is his message: 

    On Mon, Jul 1, 2019 at 10:40 PM Plewig, Gerd Prof. Dr.med. wrote:
    Dear Members of the RRDi,
     
    You may be interested that the  4th completely revised and augmented edition of Acne & Rosacea  is out.
    It is printed by Springer Milan, Italy, an can be ordered in print version, or electronically.
    The major chapter on rosacea has been  updated in text and  clinical illustrations.
    Also a new chapter on Demodex folliculorum mites with scanning electron microscopy images  is added.
    Finally a new chapter on the history of acne and rosacea is provided.
    Best wishes,
     
    Gerd Plewig
     
    Prof. Dr. Dr. h.c. mult. Gerd Plewig, FRCP
    Department of Dermatology
    University of Munich
    Frauenlobstrasse 9-11
    80337 Munich
    Germany

    239832446_411kdyli2KL._SX368_BO120420320


  3. Queta at RF has posted her regimen for demodectic rosacea: 

    "Mix .5 TBL melted coconut oil (I put it in a the micro for a few seconds because it hardens at room temp) and 5-6 drop tea tree oil. Apply to face and leave on for 40 minutes each evening. I put some on my eyebrows and a little above my eyes but use extreme caution because tea tree oil will really burn your eyes if you get some in them. After waiting 40 minutes, wash off your face and do your usual nightly skin routine. For awhile after I was done washing my face I would use coconut oil as a moisturizer because I read that mites don't like it."


  4. EQT_Logotype_39x11_300dpi_RGB.jpgADIA_logo.png

    It was announced by Galderma on its website on May 16, 2019, "Nestlé today announced that it has entered into exclusive negotiations with a consortium led by EQT and a wholly owned subsidiary of the Abu Dhabi Investment Authority (ADIA) for the sale of Nestlé Skin Health for a value of CHF 10.2 billion. The proposed transaction will be subject to employee consultations and approval of regulatory authorities and is expected to close in the second half of 2019."

     


  5. On 6/15/2019 at 11:34 AM, Rory said:

    Haven't heard of this lutein stuff Brady. Havent really been around much lately. So youre still using zz, using some topical peroxide, low carb diet and lutein. Hell of a life, eh. 

    Topical ivermectin may be the best option but some of us cant tolerate it. Im not sure any derm would be able to answer that question. Probably better to ask a vet.

    Actually I ran this by my dermatologist who was well aware that Rosaceans were using horse paste topically since he read about it in a journal. There are some dermatologists who are up to date with what is going on and then there are others who are in the dark. He told me that when prescribing Soolantra to his rosacea patients that about one in four patients were successful using it. He gave me a Rx for Soolantra and I tried it and I think now it was the inactive ingredients in Soolantra that irritated my skin. Galderma (or another pharmaceutical company) will probably eventually make an ivermectin gel with a very simple inactive ingredient list to compete with the horse paste that everyone is raving about. Galderma knows what is going on with rosaceans and obviously saw a slight dip in Soolantra sales due to thousands using horse paste. They know that a significant number of rosacea patients are not able to tolerate the inactive ingredients in Soolantra. 


  6. On 6/21/2019 at 9:27 PM, Rory said:

    Yes I'm ingesting it. I took a 250 lb dose. No, i dont weigh 250 lb. I just like the idea if a large dose. Each syringe has enough for a 1250 lb horse, so thats 5 doses per syringe. 

    Rory, thanks for clearing this up that you are taking the horse paste orally. We do have a thread dedicated to taking ivermectin orally. While many may think that taking oral ivermectin isn't a good idea, the fact is that oral ivermectin has been given to millions of people worldwide and there are long term studies on oral ivermectin in children. However, the RRDi recommends you check with your physician when embarking on this form of treatment as a precaution. It would be better you post in the oral ivermectin thread since this thread is about using horse paste topically. Thanks. 


  7. 9 hours ago, Rory said:

    I ordered Bimectin Brady. It arrived 2 days ago. Not easy to get cause its not available in some european countries. I took a dose yesterday on an empty stomach with plenty of water. Not exactly sure when i should take the next dose, maybe in a few days or next week. So, all i can do now is wait and see what happens.

    The Bimectin is topical, correct? Does it list the inactive ingredients?


  8. "The mechanism of action (MOA) of Soolantra® (ivermectin) Cream, 1% in treating rosacea lesions is unknown."

    However, we are concentrating on an investigation into the 'basis for the vehicle' statement by Galderma regarding Soolantra. 

    In the Soolantra News post if you scroll down to Cetaphil Base, Galderma, on its Mechanism of Action page, posts : "Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle." However, now this page is no longer available, but we have a screen shot of the Way Back Machine on August 21, 2018 which shows you the statement below: 

    soolantra_MOA.png

    Soolantra mechanism of action (MOA) (Way Back Machine url) 

    Actually after a careful search, Galderma has moved the statement that Cetaphil is the 'basis for the vehicle' statement to this page: 

    https://www.soolantra.com/hcp/about-soolantra-cream

    soolantra_MOA2.png

    SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use.

    While the claim by Galderma that utilizing Cetaphil is 'basis for the vehicle' we have investigated and notice the differences with the inactive ingredients in Soolantra with the ingredients in Cetaphil below. 

    SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.
    Source

    Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide
    Source

    Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet


  9. 2 hours ago, Apurva Tathe said:

    There are so many alcohols in Soolantra's inactive ingredients which cause dryness and flakiness of skin which in turn cause itching and irritation and redness. Parabens and propylene glycol are also there which tend to penetrate the skin to help allow other ingredients to enter and this may be the reason your skin reacted and couldn't handle because everyone's skin reacts differently to chemicals.

    What is interesting is that Galderma claims Soolantra's base is Cetaphil. However, we did an investigation and compared Cetaphil's ingredients with the list shown in Soolantra and discovered there is a difference. For more information: 

    Soolantra mechanism of action (MOA) 

    SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use.

    SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.
    Source

    Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide
    Source

    Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet


  10. 5 hours ago, Apurva Tathe said:

    Yes admin I had learned about the difference when I got rosacea sometimes It was sudden intense redness and bump and sometimes it was episodic redness so I researched about it because it happens with me with the onset of autumn. When the autumn starts I get sudden intense flare with redness and bumps and then the redness and bumps last longer and take time to go and during full autumn and winter after that flare-up, I get short episodic flushing very frequently which looks like it is blushing. but it is all unexpected and unanticipated about its timing. :) 

    With regard to flushing, it would be good to read this post. There are a number of drugs used to avoid flushing. There are also a number of other non prescription treatments to avoid flushing which are found here


  11. On 6/5/2019 at 11:58 PM, Apurva Tathe said:

    Yes, I had also mentioned this in my previous post quoting someone's question about tobacco and cigar causing him rosacea and I had said that you have to figure it out which food or item is triggering your rosacea and I had given my example of leaving non-veg (pointing out meat) which was causing me flare-ups and then recently I read about red meat causes skin inflammation. So the point is if any food items or drinks or smoke are triggering your rosacea and are not listed anywhere but you have to keep an eye on your diet because everyone's body reacts differently to what  they eat.

    Apurva, 

    You may be interested in reading this post, Liver, Yogurt, Sour Cream, Cheese, Eggplant, and Spinach, in the research articles section of our website to get an understanding between the difference of a rosacea flareup trigger vs a flushing trigger


  12. "In 2016, the definition of sensitive skin (SS) was established by a special interest group from the International Forum for the Study of Itch. SS is defined as a syndrome defined by the appearance of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that would not normally cause such sensations.....To our knowledge, only 2 transcriptomic studies have been performed for SS. ...As previously done with rosacea, these two studies provide very interesting data allowing, orientating and suggesting further research. Transcriptomic studies on larger populations are needed but these studies give key data to focus on some pathogenic mechanisms."

    Front Med (Lausanne). 2019; 6: 115.
    Sensitive Skin: Lessons From Transcriptomic Studies
    Adeline Bataille, Christelle Le Gall-Ianotto, Emmanuelle Genin, and Laurent Misery

    What if a non profit organization for rosacea gathered together 10,000 members, and each member donated one dollar and everyone agreed that a study on transcriptomic research be conducted? Could that be done? It is all up to you whether you think this would be worth investigating. 


  13. An article published in the Daily MailNerve injection that can stop the nightmare of hot flushes, by Robert Dobson, states, "An injection in the neck might ease the symptoms of hot flushes....known as a stellate ganglion nerve block."  Many rosaceans are more concerned with avoiding flushing than with anything else. What exactly is stellate ganglion nerve block?

    The Cleveland Clinic answers, "A stellate ganglion block is used to diagnose or treat circulation problems or nerve injuries..."

    Cedars-Sinai states, "A stellate ganglion block (sympathetic block) is an injection of local anesthetic into the front of the neck."

    Rehabilitation & Orthopaedic Institute, University of Maryland states, "A stellate ganglion block is an injection of local anesthetic (numbing medicine) to block the sympathetic nerves located on either side of the voice box in the neck."

    One paper on this subject states, "Due to a high risk of side effects, for example, pneumothorax and vascular puncture, an image-guided approach is strongly suggested, even with the "safer" C6 approach." [1] 

    "The inputs from sympathetic ganglia have been known to be involved in the pathophysiology of various conditions like complex regional pain syndrome (CRPS)" [2]

    Stellate ganglion block (SGB)
    "Stellate ganglion, also known as the cervicothoracic ganglion,....SGB is the oldest and most common sympathetic block that is applied today....There is a broad range of case studies that report the effectiveness of SGB in many different conditions. The outcomes may look promising, but expanding the indications of SGB needs more randomized, controlled studies." [2]

    End Notes

    [1] Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
    Stellate Ganglion Blocks
    Emanuele Piraccini; Ke-Vin Chang.

    [2] J Pain Res. 2017; 10: 2815–2826.
    Ganglion blocks as a treatment of pain: current perspectives
    Osman Hakan Gunduz and Ozge Kenis-Coskun

     


  14. On 6/16/2019 at 10:18 AM, Rory said:

    I've tried Soolantra a couple of times. Lasted at best about 2 months but my face couldn't handle it. No idea why maybe its the propylene glycol in it. Im going to try the oral route and see what happens. I've ordered the paste. 

    One thing i noticed each time I used Soolantra was that my face was in good condition for a while after i stopped using it. So i do think demodex has some part to play for me. 

    Rory, 
    You will probably have better results using the horse paste over Soolantra, mainly because the horse paste is stronger ivermectin 1.87% over Soolantra's 1% and also because the inactive ingredients in the horse paste are simpler than Soolantra's list of inactive ingredients. So what brand of horse paste did you order? Also please be sure to post your results of taking oral ivermectin in the oral ivermectin post here. Just look at this comparison of horse paste inactive ingredients over Soolantra's inactive ingredients to see the difference: 

    Eqvalan inactive ingredients:
    Hydrogenated Castor Oil, Titanium Dioxide (E171) 2.0% w/w., Hyprolose, Propylene Glycol

    Agri-Mectin inactive ingredients
    Corn Oil, Polysorbate 80, Apple Flavor, and Aerosil. 

    Soolantra's inactive ingredients:
    carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.

    This simple comparison explains why more positive results are with horse paste because of its simple inactive ingredient list compared to the huge number of inactive ingredients in Soolantra which may explain why some like you and me may have a side effect of dryness or whatever. Probably the other horse paste brands have few inactive ingredients just as the two we did find above. The most popular horse paste, Durvet Paste doesn't list the inactive ingredients but it probably is a list of only three "Proprietary Components".  Just about everyone reports it takes 12 weeks for clearance, but so do the positive reports using Soolantra, 12 weeks. 

     

     

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