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"Of note, the data available so far suggest that therapeutic efficacy of HCQ in COVID-19 is well overshadowed by its ineffectiveness and detrimental effects as shown by some of the above-referred studies. Therefore, it is suggested to avoid use of HCQ for COVID-19 patients (unless necessary) until clear, sufficient, well-conducted, randomized, and controlled clinical data is available to reach the right conclusions."
Front Pharmacol. 2020; 11: 582025.
Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines
Rajnish Kumar, Janmejai Kumar Srivastava, Rachana Singh, Mohammed Haris Siddiqui, Rasha A. Mansouri, Jawaher A. Abdulhakim, May N. Bin-Jumah, Saad Alkahtani, Mohamed M. Abdel-Daim, Md. Sahab Uddin -
"Till date, chloroquine is verified effective against COVID-19 in vitro through influencing bis (monoacylglycero) phosphate entry by controlling the endocytic pathway (Carrière et al., 2020). The use of chloroquine against COVID-19 might be a risk and require continuous monitoring until confirmed clinical evidence are available."
Front Pharmacol. 2020; 11: 582025.
Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines
Rajnish Kumar, Janmejai Kumar Srivastava, Rachana Singh, Mohammed Haris Siddiqui, Rasha A. Mansouri, Jawaher A. Abdulhakim, May N. Bin-Jumah, Saad Alkahtani, Mohamed M. Abdel-Daim, Md. Sahab Uddin -
"One of the recent in vitro studies conducted by Clay et al. (2020) confirmed the antiviral activity of ivermectin against SARS-CoV-2. The SARS-CoV-2 infected Vero/hSLAM cells were subjected to 5 µM ivermectin for 48 h. The study indicates about 5,000-fold decrease in viral RNA as compared to the control. This was the first study to assess and demonstrate the effectiveness of ivermectin in COVID-19."
Front Pharmacol. 2020; 11: 582025.
Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines
Rajnish Kumar, Janmejai Kumar Srivastava, Rachana Singh, Mohammed Haris Siddiqui, Rasha A. Mansouri, Jawaher A. Abdulhakim, May N. Bin-Jumah, Saad Alkahtani, Mohamed M. Abdel-Daim, Md. Sahab Uddin -
"These findings demonstrate the broad‐spectrum antiviral property of ivermectin benefiting for COVID‐19 treatment in the context of predictive, preventive, and personalized medicine in virus‐related diseases."
J Cell Physiol. 2020 Sep 22 : 10.1002/jcp.30055. doi: 10.1002/jcp.30055 [Epub ahead of print]
Quantitative proteomics reveals a broad‐spectrum antiviral property of ivermectin, benefiting for COVID‐19 treatment
Na Li, Lingfeng Zhao, Xianquan Zhan"Close to 70 clinical trials are currently in progress worldwide for SARS-CoV-2. Although few of these studies have been completed, the results that are available, as well as those from observational/retrospective studies, indicate clinical benefit. Here we discuss the case for ivermectin as a host-directed broad-spectrum antiviral agent, including for SARS-CoV-2."
Biochem Biophys Res Commun. 2020 Oct 21 doi: 10.1016/j.bbrc.2020.10.042
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2?
David A. Jansa, Kylie M. Wagstaffb -
Comments on "The Decrease of Demodex Density After Nd:YAG Laser Application for Facial Telengiactasias: A Case Report".
Dermatol Ther. 2020 Oct 27;:
Clatici VG, Voicu C, Barinova E, Tatu AL -
The RRDi has been using Invision Community forum platform since 2004. When we started in 2004 it was recommended by Warren Stuart who was the assistant director of the RRDi to use what was then called Invision Power Services (later the name was changed to Invision Community). It is a powerful platform with many add-on features and a significant number of developers adding plugins and additional features to the platform.
Invision Community Clients
Some very large corporations use the Invision Community platform. Do you recognize any of these companies below?
Are the above companies successful using the Invision Community platform?
Medical Clients Who Use Invision Community Platform
While all the above companies have their social media accounts as well, these well known companies prefer to continue using the Invision Community Platform, and so does the RRDi prefer using this same platform because of its excellent features. We have invested our donations into using this platform. So if you find this platform not to your liking and prefer the social media style platform we recommend you VOLUNTEER to help us improve our website.
Android & iOS Mobile Apps
However, with the advent of mobile devices and social media platforms the trend has focused on mobile apps using iOS and Android devices found in the Apple App Store and Google Play Store. The popularity of using these apps over using a browser to view a website has increased the use of social media platforms such as Reddit, Facebook, Instagram, Twitter, etc. The developers and owners of the Invision Community platform have announced beta versions of the Android app (iOS beta app has expired) for their platform which has been embedded for years using only a web browser, so we have announced with this post here asking for volunteers to download the beta versions and help test these new apps. Please consider volunteering and using these beta versions of the apps.
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Artificially Sweetened Drinks
"Records for 104,760 participants were included....Artificially sweetened beverages were defined as those containing non-nutritive sweeteners. Sugary drinks consisted of all beverages containing 5% or more sugar....Researchers looked at first incident cases of cardiovascular disease during follow-up from 2009-2019, which were defined as stroke, transient ischemic attack, myocardial infarction, acute coronary syndrome and angioplasty. After excluding the first three years of follow-up to account for potential reverse causality bias, 1,379 participants had first incident cases of cardiovascular disease. Compared to non-consumers, both higher consumers of sugary drinks and of artificially sweetened beverages had higher risks of first incident cardiovascular disease, after taking into account a wide range of confounding factors..."
Artificially sweetened drinks may not be heart healthier than sugary drinks, Medical Xpress, October 27, 2020, research letter in the Journal of the American College of Cardiology,
Sugar Any Better?
"Drinking one or more sugary beverages a day was associated with a nearly 20% greater likelihood of women having a cardiovascular disease compared to women who rarely or never drank sugary beverages, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association."
California study finds drinking sugary drinks daily may be linked to higher risk of CVD in women, Medical Xpress, May 13, 2020, by American Heart Association
Research on Sugar Beverages Triggering Rosacea
Do you think it is possible for a non profit organization for rosacea get its members to each donate one dollar to investigate whether or not sugar beverages or artificially sweetened drinks are a rosacea trigger in a double blind, placebo controlled, peer reviewed clinical study? It would take approximately 10K members to do this if the members wanted this. What do you think? Have you noticed whether drinking a sugar beverage triggers your rosacea?
*Image credit CCO public domain
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13 Variants of Rosacea
The RRDi recognizes these thirteen variants of rosacea:
Gastrointestinal Rosacea [GR], aka, Gut Rosacea
Idiopathic facial aseptic granuloma (IFAG)
Rosacea Fulminans
Rosacea Lymphedema (Morbihan Disease)Rosacea Perioral Dermatitis [RPD]
Steroid Rosacea [Facial corticosteroid addictive dermatitis] (FCAD)
Etcetera
Variant vs Subtype vs Phenotype
Reply to this Topic
There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.
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An article on the pathophysiology of rosacea overlaps with demodectic rosacea and the phenotype classification. Below are the three highlights considered in the paper:
(1) New hypotheses to explain how Demodex mites may control host immunity, by analogy with what happens in tumor pathology: inducing tolerogenic dendritic cells through their Tn Ag, and diverting the body's defence reaction by exploiting the immunosuppressive properties of VEGF;
(2) Leading to consider rosacea not as a disease of the innate immunity, but as a chronicle infection by Demodex with T cell exhaustion;
Highlighting of the ambiguities of the current definition of rosacea of the NRS, and the overlap with demodicoses, suggesting that all these dermatoses are different phenotypes of the same disease;(3) The suggestion, for the dermatologists, to learn to detect the demodicoses among the patients with persistent erythema, in the aim to treat at least these patients with topical acaricidal treatment.
The article concludes, "The interactions among VEGF, Demodex, and the immune system need further exploration and the nosology of rosacea would then need to be adapted accordingly. The effectiveness of treating any patient with ETR first with an acaricidal cream needs to be assessed in prospective controlled clinical trials with long-term follow-up. Currently, learning to distinguish patients with pityriasis folliculorum from those with isolated ETR is crucial so that they can be managed appropriately with an acaricidal cream." [1]
Another article explains it this way:
"According to dermatology literature, Demodex is found to colonize normal human skin everywhere; on an average, the Demodex population is approximately 5/cm2 of skin in the adult population. They usually do not result in any dermatological problems, but when the parasites penetrate the dermis, they can cause acne, rosacea, and folliculitis. The symptoms aggravate with an increase in their population. Rosacea is a disease of multifactorial origin, and the individual characteristics of the patient can modify the severity of the inflammatory response to Demodex. Finding large quantities of Demodex may play an important role in the pathogenesis of rosacea in addition to other trigger factors." [2]
End Notes
[1] Forton, F.M.N. The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?. Dermatol Ther (Heidelb) (2020). https://doi.org/10.1007/s13555-020-00458-9
Image courtesy of Dermatology and Therapy
[2] Indian J Ophthalmol. 2018 Jan; 66(1): 36–38.
Demodex and rosacea: Is there a relationship?
Diana Gonzalez-Hinojosa, Alejandro Jaime-Villalonga, Gustavo Aguilar-Montes, and Lorena Lammoglia-Ordiales -
Volunteer Beta Developers Needed! (Android & iOS) Wish List
If you are a code developer and want to volunteer for our non profit organization for rosacea to develop a mobile app for either Android or iOS please contact us.
Note: We have applied our community forum with Invision Community to list us under EDUCATION and we were approved on the list.
There WAS a mobile app available in beta version for Android (for Apple devices using iOS you need to scroll further down). It was on the Google Play store. It is the Invision COMMUNITIES app (not the Invision Community app which is for admins ONLY). Yes this is confusing, since it was in development and both the iOS and Android apps are no longer in development. Here is a screen shot that was in the Google Play Store which is the second one called Invision COMMUNITIES:
We listed our community, the RRDi, when the above 'Communities' apps was available in the Google Play Store and you may be able to find our listing in the category EDUCATION. Please let us know your experience with this app on your Android mobile device? Just find the reply to this topic button and let us know, please. If you are a code writer developer and would like to volunteer to make a mobile app for our RRDi Invision Community please join the RRDi and explain in your profile your volunteer spirit.
Please note: The iOS beta test has expired. We are not aware when Invision Community will renew the iOS beta test again. We will announce this here whenever the beta test is available again. The Android version development has been put on hold by the Invision Community developer team. If this app ever is developed further we will announce it on this post.
iOS (Apple) Version
The iOS version is no longer in beta testing. When available again, You can volunteer and be a beta tester if you follow the two steps:
Once you have downloaded the app, at the bottom click on DISCOVER, you will find these categories to choose from and then select EDUCATION and scroll till you find RRDi Member Forum:
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As of this date there are at least 80 systemic comorbidities listed associated with rosacea. Can you find anywhere on the internet a list like this? That is what the RRDi is about, 'everything rosacea.' We attempt to have on one website a comprehensive database of 'everything rosacea.' Can you find all the information on rosacea at the other non profit organizations for rosacea? Why not browse the other non profit organizations for rosacea and see if they even come close to all the data we have categorized into logical categories for your investigative research into rosacea? Do they have the data you are finding on the RRDi website about rosacea even comes close to what you have discovered here on this website? For example, do they even mention non prescription treatments for rosacea such as over the counter topicals and allowing REVIEWS of these treatments? Or why not go to your favorite rosacea social media platform like on Reddit, Facebook, Twitter or Instagram and see if you can logically figure out how to search for a subject you are investigating. Difficult task, isn't it? If you appreciate the data found on our website, why not volunteer and support the RRDi? Could you at least donate one dollar so we can keep this website running?
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According to PRNewswire, New York, dated December 5, 2018, 'rosacea therapeutics demand to exceed $2 billion dollars.' This report includes an interesting factoid that "In the consolidated competitive landscape of rosacea therapeutics market, four leading companies account for over 75% share of the total market value, including Pfizer Inc., Teva Pharmaceutical Industries Ltd., Foamix Pharmaceuticals Ltd., and Bayer A."
Rosacea Therapeutics Demand to Exceed US$ 2 Billion in 2019 - Persistence Market Research, PRNewswire, 12/5/2018
Reply to this Topic
There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.
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"Today, Aug. 21, 2019, a Delaware court issued an opinion finding three key patents covering Galderma’s Soolantra acne cream invalid and not infringed by Teva’s generic product....The FDA granted tentative approval to Teva’s generic product in March of this year; because of today’s decision, the FDA is now permitted to grant final approval. Today’s opinion is favorable for Teva, which may now launch its generic product at risk once it receives final approval from the FDA."
(TEVA) Soolantra: Delaware Court Finds Galderma Patents Invalid; Teva May Launch Generic Version of Soolantra At Risk Pending FDA Approval, August 21, 2019, Reorg
"On January 29, 2020, the Federal Circuit reversed and remanded an August 21, 2019 decision (Galderma v. Teva, 390 F.Supp.3d 582 (2019)) handed down by the United States District Court for the District of Delaware in the patent infringement dispute between Galderma Laboratories and generic manufacturer, Teva Pharmaceuticals, relating to Teva’s Abbreviated New Drug Application (“ANDA”) seeking approval to market a generic version of Galderma’s Soolantra® (1% ivermectin cream for topical use) for treating inflammatory lesions of rosacea."
Galderma Prevails At The Federal Circuit, Forcing Case Back To The District Court To Consider Teva’s Additional Invalidity Theories, Wolf Track Life Sciences IP Blog, Posted by Gabe McCool on Feb 10, 2020
"The January 29, 2020, Federal Circuit decision in Galderma Laboratories, L.P. v. Teva Pharmaceuticals USA, Inc., is a non-precedential decision that was issued on the briefs (without oral argument), but is worth reviewing for its discussion of anticipation and inherency in the context of method of treatment claims. The decision shows that even in the context of anticipation, establishing inherency can be a high burden to carry."
Necessity Is The Mother Of Single Reference Anticipation By Inherency, Courtenay C. Brinckerhoff, Foley & Lardner LLP
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This is a note from the RRDi Treasurer about grant writing basics. Please read this page first!
The RRDi received some education grants from Galderma which you can review here:
https://irosacea.org/articles/rrdi-education-grants/
Grant writing is a tedious and arduous task and we appreciate your volunteering to help us.
We went through all sorts of hoops with Galderma to get those grants. Now the process has changed and we are still trying to figure it out. What each company requires is different and you have to go through hoops to learn.
Basically, it would be prudent to try to learn how to apply for grants from pharmaceutical companies that make rosacea treatments. You can learn what prescription treatments for rosacea are here:
https://irosacea.org/forums/forum/21-prescription-treatments/
Some of the major pharmaceutical companies that make rosacea treatments are:
Galderma, Allergan, Alma, Almirall, Bayer, BioPharmX, Bristol Meyers, Candela, Chicet, Clinique, Cutanea, EPI Health, Foamix, GSK, Havione, Johnson & Johnson, Roche, Pfizer, Salix, Sanofi, Sol-Gel
Contacting these pharmaceutical companies and asking them what the hoops are to go through to obtain grants is what you should do. We have Medical Advisory Consultants who might answer some questions about rosacea if you need to know anything. The list is found here:
Go through Apurva Tathe with your questions first since she has access to contacting the RRDi MAC members above in the list if you have medical rosacea research questions.
There are, of course, foundations that offer money for grants and each foundation has its hoops to go through, i.e., Bill and Melinda Gates Foundation
https://www.gatesfoundation.org
And there are many others. You can google 'how to apply for grants' which will give you more results.
When filling out forms use the following:
Address:
Rosacea Research & Development Institute
PO Box 858
Centre, AL 35960EIN 20-1259275
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"It was detected that number of Demodex affected from the glucose level and each increase in glucose level cause an increase on Demodex as 0.190 (P = .00, t = 4.746, B = 0.190, r = 0.57, Durbin-Watson = 1.801, confidence interval = 0.110 to 0.271 (for glucose))."
J Cosmet Dermatol. 2020 Oct 05;:
Association between Demodex folliculorum and Metabolic Syndrome.
Toka Özer T, Akyürek Ö, Durmaz S -
You can make a difference while you shop Amazon Prime Day deals on October 13 & 14. Simply shop at smile.amazon.com/ch/20-1259275 or with AmazonSmile ON in the Amazon Shopping app and AmazonSmile donates to Rosacea Research And Development Institute.
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Now available announced by Vyne Therapeutics. Ask your dermatologist. Post your experience in this thread. Find the reply button."The Company also announced that the annual list price of ZILXI will be $485 per 30-gram canister, in parity with the wholesale price of AMZEEQ® (minocycline) topical foam, 4%, the Company's topical minocycline indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in adults and pediatric patients 9 years of age and older."
PR Newswire Association LLC. All Rights Reserved. A Cision company -
Molecular functional analysis circulating RNA of patients presented as effective to ISO therapy image courtesy of PubMed Central."In conclusion, we found that isotretinoin could temporarily alter gene expression in acne patients, and the gene profiles among oral ISO-induced acne flare-up, effective, and ineffective patients were distinct. ISO therapeutic mechanisms were not only involved in regulating the inflammatory reaction but also in the process of DNA repair. Genes that regulated the inflammatory and defense response to microorganisms played a role in ISO treatment effects. GATA2, C4BPA, CCR5, DEFA3, ELANE, MMP9, and RPS4Y1 might be the susceptible genes implicated in ISO-induced acne aggravation. These findings revealed the genetic roles in the ISO treatment process and provided a basis for exploring precise personalized treatment plans for acne patients."
Pharmgenomics Pers Med. 2020; 13: 385–395.
Altered Gene Expression in Acne Vulgaris Patients Treated by Oral Isotretinoin: A Preliminary Study
Yuchen Jiang, Haiyan Chen, Le Han, Xiaoyuan Xie, Yue Zheng, Wei Lai -
"Overall, the current study demonstrates that topical minocycline gel is safe, efficacious and well tolerated in patients with papulopustular rosacea. The findings of this study support further evaluation of topical minocycline gel for the treatment of papulopustular rosacea."
Br J Dermatol. 2020 Sep; 183(3): 471–479. With Photos
A multicentre, randomized, double‐masked, parallel group, vehicle‐controlled phase IIb study to evaluate the safety and efficacy of 1% and 3% topical minocycline gel in patients with papulopustular rosacea
G. Webster, Z.D. Draelos, E. Graber, M.S. Lee, S. Dhawan, M. Salman, and G.N. Magrath -
9 hours ago, MSR said:
Thanks, correct spelling is Melazepam. We have that in our affiliate store so if anyone wants to check it out and purchase it the RRDi gets a small affiliate fee that helps us out a tiny bit.
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On 9/26/2020 at 2:28 AM, MSR said:
Thanks for the update! AA via the weird Malazapham (sp) from Amazon was one of my "false dawns." It's 20% and I jumped into using it twice a day. I lasted two weeks and it was clearing things but was super irritating to my skin. I had to stop. I will experiment with adding it in a few times a week. I'm thinking we need to have a multi-pronged approach to this. (1) Kill the yeast, (2) repair the damaged skin barrier, (3) remove the excess keratin/heal the bumps, (4) repopulate the skin microbiome. Tom's products should do the first three, albeit it very slowly.
What is 'Malazapham' ?
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Do you think that any rosacea non profit organization would do any research as this paper suggests, "that this opens a horizon for more research in the link between the skin and nervous system,"? Most of the research on rosacea is profit motivated since the skin industry promotes and sponsors most of the clinical research papers on rosacea. In comparison to non profit rosacea research who would investigate this? Could a grassroots non profit organization for rosacea gather enough donations to investigate this subject? What do you think? For more information.
Are you aware that PD is also associated with lewy body dementia?
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I was thinking about buying Tom's Lotion (used only the shampoo for about three months, not the lotion) but my dermatologist asked me if I have ever tried Azelaic Acid, which I have heard about since 2007 but never tried it. So I took her recommendation and have been using Azelaic Acid and you can review my updates on this in my rosacea blog. I have tried a long list of treatments mentioned in my blog to try to clear the folliculitis in my scalp and nothing cleared it. The Azelaic Acid has been the only thing so far that has taken away the itch and has definitely improved it. I will continue to use Tom's AquaVive shampoo to cleanse my scalp but will be using the Azelaic Acid for a couple more months, since usually it takes three months for any treatment for clearance.
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Finacea Foam 15% For Folliculitis
in Azelaic Acid
Posted
"Azelaic acid 15% foam used off-label might be a useful treatment or adjunctive therapy for folliculitis." [1]
"Off-label prescribing is when a physician gives you a drug that the U.S. Food and Drug Administration (FDA) has approved to treat a condition different than your condition. This practice is legal and common. In fact, one in five prescriptions written today are for off-label use." [2]
In one clinical trial using azelaic acid for demodectic folliculitis it states, "The purpose of this study is to measure the effects of azelaic acid on Demodex folliculorum counts and disease condition via a split face design in approximately twenty patients with mild to moderate rosacea. The investigators hypothesize that treatment of rosacea with azelaic acid will lead to a decreased Demodex folliculorum count as well as an improvement in lesion count and redness." [3]
More information on Azelaic Acid (for rosacea)
End Notes
[1]J Clin Aesthet Dermatol. 2020 Apr; 13(4): 36–38.
Examining 15% Azelaic Acid Foam for the Treatment of Folliculitis: A Pilot Study
Zoe Diana Draelos, MD
[2] Off-Label Drugs: What You Need to Know, Agency for Healthcare Research and Quality, An official website of the Department of Health and Human Services
[3] zelaic Acid on Demodex Counts in Rosacea, ClinicalTrials.gov Identifier: NCT03035955