Guide

Topical probiotics in the form of various dermatological formulations are an important part of the treatment of skin conditions. 

Pharmaceutics. 2022 Mar; 14(3): 557.
Topical Probiotics: More Than a Skin Deep

An article on the GUT BRAIN SKIN axis concluded the following: 

"In summary, we found that chronic antibiotic use during midlife was associated with minor decreases in cognitive scores assessed a mean of 7 years later. These data provide a better understanding of potential complications of antibiotics throughout life, as well as generate hypotheses about the role of the gut microbiome in cognition."

PLoS One. 2022; 17(3): e0264649.
Association of midlife antibiotic use with subsequent cognitive function in women

The FDA has approved MinoLira for treating acne which is a timed release minocycline hydrochloride tablet manufactured by EpiHealth. (if you are seeing error messages, i.e., see screenshot below, you are not an active member, learn more😞

To learn more register and subscribe to become an active member. 

The FDA has approved MinoLira for treating acne which is a timed release minocycline hydrochloride tablet manufactured by EpiHealth. You may learn more about a savings card program on the official web site. It has not been approved for rosacea yet. Minocycline has been used for many years to treat rosacea. You may be interested in asking your dermatologist about minolira (timed released) or simply a generic minocycline which has been used for many years and proven just as effective as taking Oracea (doxycycline). 

Ivermectin worthless against COVID in largest clinical trial to date

Arstechnica

"This is the first case report of demodicosis associated with wearing a face mask."

PubMed RSS Feed - -Demodicosis Associated with Wearing a Face Mask: A Case Report

We have a page on volunteering for the RRDi. We are currently in need of moderators for the Guest and Member Forums. Everyday we receive plenty of guest posts which are mostly in Russian, spam for pornography or selling wares or treatments for rosacea or for just about anything on the internet. We have to flag the spammer and delete the posts. This is a tedious and time consuming volunteer work. Let me ask you, if you were running a non profit for rosacea like the RRDi, would you appreciate getting huge donations from the skin industry like the NRS, the AARS and the ARSC (scroll down to 'Other Non Profit Rosacea Organizations' on this page) or would you prefer an independent rosacea non profit run by volunteers who care about other rosacea sufferers totally independent of the skin industry?  

If we don't get volunteers to help the RRDi we will be shutting down unless we can get enough donations somehow to pay employees or contractors like the NRS, the AARS and the ARSC does or get enough volunteers to run this non profit.

You will always have the NRS, the AARS and the ARSC because they are entrenched with the skin industry sponsoring these non profits for rosacea.

The RRDi is the only independent rosacea patient advocacy grassroots non profit for rosacea period. Step up to the plate and volunteer. Or if you prefer your favorite rosacea social media platform, why not Volunteer for the RRDi Social Media accounts?

In 2010 we published our first edition of the Journal of the RRDi through iUniverse, which cost us a significant amount of donated funds. We are now in a position to publish our next edition of the Journal of the RRDi and announcing this in our guest forum first to let guests know that we are accepting author contributions which will be reviewed and possibly published in our journal. We will be doing this totally with volunteers (no one is being paid) including no compensation to the authors we publish in our journal. At this time we are considering some sort of peer review process but as this is a very complicated and costly process, we may opt out if we can't comply with what is normally accepted as a clinical or medical peer review process. [1] 

"Clinical peer review should be distinguished from the peer review that medical journals use to evaluate the merits of a scientific manuscript, from the peer review process used to evaluate health care research grant applications, and, also, from the process by which clinical teaching might be evaluated. All these forms of peer review are confounded in the term Medical Peer Review." [2]

What most rosaceans are totally unaware of is the peer review process is not only complicated but also controversial. For example this paper explains: 

"It's an example of an open secret in medicine: Many of the articles that appear in scientific journals under the bylines of prominent academics are actually written by ghostwriters in the pay of drug companies. These seemingly objective articles, which doctors around the world use to guide their care of patients, are often part of a marketing campaign by companies to promote a product or play up the condition it treats." [3]

The NRS, the AARS, and the ARSC (other rosacea non profit organizations) have engaged in most of the non profit rosacea research that has been done, sponsoring authors with grants that are primarily supported by donations from the skin industry, particularly the pharmaceutical companies that treat rosacea. The RRDi is the only non profit for rosacea that is totally a patient advocacy grassroots non profit that is not supported by the skin industry and functions totally independently. 

If you would like to submit an article to be published in our next edition of the Journal of the RRDi, please click on the large SUBMIT button on our journal page by registering an account and following the directions on how to submit. 

Also, if you wish to volunteer as a proof reader, graphic artist or in technical support, please join the RRDi and mention in your profile that you want to volunteer. The RRDi is the lone watchdog on what the other rosacea non profit organizations are doing and is totally independent of the skin industry, even though we have repeatedly asked the pharmaceutical companies to donate to the RRDi. 

Brady Barrows
RRDi Treasurer

End Notes

[1] Peer Review, Wikipedia

[2] Clinical Peer Review, Wikipedia

[3] Ghost Story, At Medical Journals, Writers Paid by Industry Play Big Role, December 13, 2005, By ANNA WILDE MATHEWS
Staff Reporter of THE WALL STREET JOURNAL, DowJones Reprints • Order a reprint of this article now.

 Watch Video

Rosacea is associated with a number of other diseases, referred to as ‘systemic comorbidities’, which one study reports, “Clinicians must be aware of the potential for systemic comorbidities in rosacea patients, which becomes more likely as disease duration and severity increase.”

We have a post on this with a list of what systemic comorbidities may be involved. To view this post, you will need to register as a subscribed member. 

We have an interesting post on anonymity, transparency and posting. Here is the introduction: 

"You may have some thoughts on the subjects of anonymity, transparency and posting on the internet. This post is our explanation of how we understand these three subjects and if you have any thoughts on this, you are welcome to hit the REPLY TO THIS TOPIC button and add your thoughts."  

Read More

Freemium vs Subscription 

About a month ago we started the subscription plan using our Invision Community platform and asked for $12/year which is one dollar a month and received only one donation. About two weeks ago reduced the minimum to $6 and received no results. Yesterday, reduced it to $1 minimum for one month subscription and got one member. So we will try this for thirty days and see how it goes. When a member joins and uses PayPal, the PayPal fee is 51 cents so the RRDi only gets 49 cents as a donation. We had to change this to a two dollar donation to help pay for the PayPal fee for one month access. If you could simply choose a three, six month or twelve month subscription that would really help us out.  We will update our progress with our new subscription based rosacea member forum over giving away everything for free. You probably have noticed over the years if you have been on the internet for a while that there is a difference between Freemium vs Subscription models according to Dignitas Digital. We have tried the freemium since 2004 and rosaceans have really changed. While in the past they loved the forum style model that was popular back then and posted freely, now a younger set of rosaceans have emerged totally bent on social media platforms that give freemium and find the forum style platform antiquated and not 'user friendly.' However, the forum style platform has been heavily influenced by the social media platforms and imitate its style. If one can manage a social media platform, this same person can easily click their way through our Invision Community forum style platform, so the question comes down to does the RRDi continue giving away our huge database of rosacea information on our website for free or should we charge for it? You need to  clearly understand that social media, while popular, is freemium at a hidden price.  While you can give away free information for a while if you have enough money to continue giving it away for free, the point is that giving away anything for free still incurs cost and unless there is enough money to continue giving it away for free, eventually, if the money runs out, the end of the freemium platform also ends. Yes, this is a wordy post, but you should see all the wordy posts we have on rosacea in our subscription based member forum platform. Way more information in logical categories and an excellent rosacea search engine that social media rosacea platforms are wanting. Guests, do you have any comments about any of this (commenting requires a subscription)? Why not try finding the reply to the topic button or the quote button and post your thought or comment and hide behind a cryptic display name that keeps you totally private so no one knows who you are. Would that take you a few minutes of your precious time?  Would it cost you what you spend on a cup of coffee? Yes it would. The RRDi would appreciate your comment and allow it to be published in this thread. What an honor you would receive with your cryptic name display (honor? Yes, you are showing with your cryptic display name that you are either humorous or worthy of your comment). A subscription shows you are supporting the RRDi with a minimum donation. Do you think what you have visited as a guest is worth becoming a subscription member? If not, find on the internet what you are searching for with rosacea that gives everything away for free (freemium). Before you go, why not check out our site index to see if what you are searching for has been discussed on our website. 

Keep coming back to this post to see our progress with the subscription based platform. 

This post was originally titled "Update on the RRDi Guest Forum 3/12/2022" however we changed the title in August 2022.

On 10/10/2021 at 9:22 AM, Guest Jennifer said:

I have rosacea on my nose.  I have had it for 3 years, with little notice, but now it is getting really bad with bigger pores and bumps getting bigger and bigger on top and sides of my nose.  I have taken the  2 prescription medications recommended with poor results.  I have had it scraped 1 time 2 years ago but it did nothing.  I have alcohol a couple times a month.  Does anyone know what can slow down the process on the nose please?

We do have a post on alcohol and rosacea but you have to register and become a member to view the post. If you use our search box on the home page at the top and type in 'alcohol' you can read a list of posts on this subject which are numerous and you could search through them but again, you need to register an account and become a member to view most of these posts since guests are only allowed to view a small percentage of our rosacea data. 

Click here for a blurb about our post on alcohol and rosacea. 

Hydroxychloroquine is an essential element of the dermatologist’s therapeutic arsenal. It is indicated as first- or second-line therapy in many photoinduced and photoaggravated inflammatory and granulomatous skin diseases. Using hydroxychloroquine for the treatment and prevention of COVID-19 has proven unsatisfactory and led to supply difficulties. Greater caution is required when recommending large-scale, off-label prescription of hydroxychloroquine to ensure that patients who need this drug have access to it.

Hydroxychloroquine: An Essential Drug in Dermatology and Its Controversial Use in COVID-19

Topical creams minimise facemask complications, thereby promoting compliance; topical lidocaine was the most effective in reducing pain and enabling facemask compliance. Topical hydrocortisone, diphenhydramine, and zinc oxide were effective in reducing facial redness, and topical petrolatum produced the best user satisfaction.

Facial topical cream promotes facemask tolerability and compliance during COVID-19 pandemic

An interesting article in our member forum worth reading is, Specialized Pro-resolving Mediators for Rosacea?

Lipoxygenase image courtesy of Wikimedia Commons

In an article published in National Geographic, a new approach is discussed to treating inflammatory diseases (one theory is that rosacea is an inflammatory disease) using Specialized Pro-resolving Mediators (SPM) which were discovered in the 1990s by Charles Serhan, a professor of anesthesia at Harvard Medical School. [1] Prominent SMP members include the resolvins and protectins. [2]

"SPM join the long list of other physiological agents which tend to limit inflammation (see Inflammation § Resolution) including glucocorticoids, interleukin 10 (an anti-inflammatory cytokine), interleukin 1 receptor antagonist (an inhibitor of the action of pro-inflammatory cytokine, interleukin 1), annexin A1 (an inhibitor of formation of pro-inflammatory metabolites of polyunsaturated fatty acids), and the gaseous resolvins, carbon monoxide (see Carbon monoxide § Physiology), nitric oxide (see Nitric oxide § Biological functions), and hydrogen sulfide (see Hydrogen sulfide § Function in the body and Hydrogen sulfide § Involvement in diseases)." [2]

The cytokines mentioned above are related to the Immune System Disorder theory of rosacea. [3]

Serhan was searching for fatty lipid molecules when he identified lipoxin that seemed to reduce inflammation. "Scientists speculate that one way lipoxins and other pro-resolution molecules work is by interacting with immune cells called macrophages." [1]

"A lipoxin (LX or Lx), an acronym for lipoxygenase interaction product, is a bioactive autacoid metabolite of arachidonic acid made by various cell types." [4]

"SPMs are being tested extensively in animal models of diseases like cancer and sepsis, and more modestly in small patient trials studying eczema and periodontal disease." [1] Whether SMPs are ever being considered to treat rosacea remains to be seen. Could a non profit organization for rosacea patient advocacy like the RRDi engage in a small patient trial studying rosacea? Depends if you can get enough members to get together to sponsor such a trial. 

Learn more about rosacea research.

End Notes 

[1] The end of inflammation? New approach could treat dozens of diseases., Connie Chang, National Geographic
Published March 4, 2022

[2] Specialized Pro-resolving Mediators, Wikipedia

[3] Innate Immune Response Disorder Theory

[4] Lipoxin, Wikipedia

Therefore, KLK5 inhibitors are considered as therapeutic agents for improving the underlying pathophysiology and clinical manifestation of rosacea. Here, we isolated the active constituents of Artemisia lavandulaefolia (A. lavandulaefolia) and investigated their inhibitory effect on KLK5 protease activity.

PubMed RSS Feed - -Chlorogenic Acid Isomers Isolated from Artemisia lavandulaefolia Exhibit Anti-Rosacea Effects In Vitro

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Artemisia lavandulaefolia has been known to use in the traditional medical practices. 

Extract of Artemisia lavandulaefolia Inhibits In Vitro Angiogenesis in Human Umbilical Vein Endothelial Cells

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"Artemisia is a large, diverse genus of plants with between 200 and 400 species belonging to the daisy family Asteraceae. Common names for various species in the genus include mugwort, wormwood, and sagebrush." Wikipedia

Herein, we report the cases of 3 patients who presented with erythema on their hands and feet after dupilumab injections.

Asia Pac Allergy. 2022 Jan; 12(1): e1.
Acral erythema arising in patients with atopic dermatitis after dupilumab therapy: A case report of 3 patients
Young Jae Kim, Mi Young Lee, and Chong Hyun Won

An article on cosmeceuticals concluded, "Most people choose to use natural beautifying items for healthcare purposes. Now currently, there is an extremely large interest in everyday natural beauty care merchandise. Sound teeth, gleaming hair, and shining skin are noteworthy for the attractiveness of the human frame. Various herbal elements/additives used in natural formulations contain bleaching agents, fixed oils, perfuming agents, waxes, antioxidants, protective agents, herbal colorants, critical oils, and plant fabrics that include leaves, gums, mucilage, etc. Herbal formulations comprising herbal substances are side lining synthetic ingredients quite successfully. On the basis of data represented here indicated the use of herbal medicines and bioactive compounds for cosmetic purpose and treatment of various diseases and it relies upon on the correcting redient requirements and superiority of product. Herbal cosmetics must undergo proper control measures for protection as it is of outstanding significance."

Molecules. 2022 Feb; 27(3): 828.
Bioactive-Based Cosmeceuticals: An Update on Emerging Trends
Anju Goyal, Aditya Sharma, Jasanpreet Kaur, Sapna Kumari, Madhukar Garg, Rakesh K. Sindhu, Md. Habibur Rahman,Muhammad Furqan Akhtar, Priti Tagde, Agnieszka Najda, Barbara Banach-Albińska, Katarzyna Masternak,8 Ibtesam S. Alanazi,9 Hanan R. H. Mohamed, Attalla F. El-kott, Muddaser Shah, Mousa O. Germoush, Hamdan S. Al-malky, Salman H. Abukhuwayjah, Ahmed E. Altyar, Simona G. Bungau, Mohamed M. Abdel-Daim

"Cosmeceuticals are cosmetic products with bioactive ingredients purported to have medical benefits. There are no legal requirements to prove that these products live up to their claims. The name is a portmanteau of "cosmetics" and "pharmaceuticals". "Nutricosmetics" are related dietary supplement or food or beverage products with additives that are marketed as having medical benefits that affect appearance."
Cosmeceutical, Wikipedia

If you have registered an account with the RRDi you probably are in the inactive member group. The definition of an inactive member is one who has not posted in the last thirty days. Beginning in February 2022 we have basically allowed guests and inactive members to view about 5% of our website.  We now have switched to a subscription based website so that active members can view the entire website if they donated $1/month. We have had to do this to assure we can continue to publish this website though Invision Community hosting services. If we don't have enough paid subscriptions to keep our non profit organization functioning through this website we will deem this to mean not enough rosaceans want to keep this going and simply shut down. 

Another option to become an active member who does NOT want to post is simply donate $12 and we will note this on your registered account and you will gain 12 months of full access to the site. 

If you are having any issues logging into your account, use our contact form and give us your email address you used to register your account and we can help you login by resetting your password. 

If you have any questions about any of this, find the reply to this topic button and post. 

"Natural coumarins present in a variety of foods and herbs are a class of chemically diverse compounds with important biological effects, useful for health promotion and the prevention of various diseases. The most important adverse effects of coumarins are represented by hepatotoxicity favored by the ingestion of large doses and possible genetic polymorphism of CYP2A6 and dermatological phototoxic reactions. A better understanding of the safety profile of coumarins present in nutraceuticals is necessary for a safer use of these valuable natural compounds."

Front Pharmacol. 2022; 13: 803338.
Safety Profile of Nutraceuticals Rich in Coumarins: An Update
Simona Codruta Heghes, Oliviu Vostinaru, Cristina Mogosan,  Doina Miere,  Cristina Adela Iuga, Lorena Filip 

Our website is now a subscription based members only website. 95% of our website requires a donation of $12/year so we can keep this website going. Guests can only view about 5% of our website. Please register and donate $12 for a twelve month subscription. Thanks for your donation! We had to switch to a subscription based website as a last resort to see if we can keep this website going. If we don't get enough subscriptions or receive donations to keep our non profit organization website going we will be closing up shop here and no more non profit organization for rosacea patient advocacy. Why not find the reply to this topic button and post your comment or question? 

Scroll below to understand what guests can view and what subscribed active members can view.

Our website is now a subscription based members only website. 95% of our website requires a donation of $2 ($1/month for three or more months) to be able to post so we can keep this website going. Guests and inactive members may view about 95% of our website. Please register and donate $2 for a one month subscription. A minimum of one month is required which is just two dollars a month. Thanks for your donation! About the RRDi. We need 100 active subscribers!

Guests May View the Following Without Registering (95% of our website)

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Registered Active Members and Guests Have Access to the Following (95% of our website)
Over 7K posts & articles of rosacea information!

• All Pages/Posts Guests Can Access (see the list above)• All the Subforums in Photo Dynamic Therapy (PDT) • All the Subforums in Non Prescription • All the Subforums in Prescription • All Subforums of Rosacea Theories • All the Subforums in Rosacea Topics • All Subforums in Trigger Avoidance • All the Topics in Ask the Board • All the Topics in Ask the MAC • Announcements and News • Articles (Rosacea) • Community Support • Co-Existing Conditions • Cosmetics • Demodectic Rosacea Forum •  Diagnosis • FAQs Subforum • Funding Committee • Finding Rosacea Topics on a Mobile Device • Grant Writers Public Forum • Inactive Members • Member Forum • Newbie Rosaceans • OFF TOPIC • Probiotics • Public Relations • Phenotypes, Subtypes, Rosacea Variants & Mimics Subforum • Rosacea in the News •  Rosacea Research • Rosacea in Remission • Rosacea & Psychology • Rosacea Topics • RSS • Secondary Therapy • Triggers •

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If you are seeing error messages when trying to access areas only registered active members are allowed to enter since these areas are not open to guests or inactive registered members. Read more about error messages. 

Member Information

There is now a a minocycline extended-release oral capsule, similar to doxycycline (Oracea). For more information.