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Guide

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  1. Oilshale.jpg
    Image of naturally burning oil shale on a coast near Kimmeridge, on 18th August 2000, courtesy of Wikimedia Commons

    What is Sodium Bituminosulfonate?
    "Ammonium bituminosulfonate or ammonium bituminosulphonate (synonyms of ichthammol, CAS#8029-68-3 brand name: Ichthyol) is a product of natural origin obtained in the first step by dry distillation of sulfur-rich oil shale (bituminous schists)." Wikipedia

    "There are also no systematic studies on the use of schist oil extracts such as ammonium bituminosulfonate and sodium bituminosulfonate;" [1]

    "Most tar compounds are derived from coal tars, but oil shale tars (ichthammol), juniper tars (cade oil), or pine tars are sometimes used." [2]

    Sodium Bituminosulfonate for Rosacea
    It is of interest to note that a paper states, "Sodium bituminosulfonate is derived from naturally occurring sulphur-rich oil shale and is used for the treatment of the inflammatory skin disease rosacea....The aim of this study was to address the molecular mechanism(s) underlying the therapeutic benefit of the formulation sodium bituminosulfonate dry substance (SBDS), which is indicated for the treatment of skin inflammation, including rosacea....In summary, SBDS reduces the generation of inflammatory mediators from human neutrophils possibly accounting for its anti-inflammatory effects in rosacea." [3]

    Another paper on this subject states, "The aim of this study was to address the molecular mechanism(s) underlying the therapeutic benefit of the formulation sodium bituminosulfonate dry substance (SBDS), which is indicated for the treatment of skin inflammation, including rosacea." [4]

    History of Sodium Bituminosulfonate
    "One of these “old” substances is ammonium bituminosulfonate, which was already introduced in 1882 as “Ichthyol”. Its pale analogue was made known in the 1930s as “Ichthyol, light”. However, the mechanism of the antimicrobial activity of bituminosulfonate is still unclear. These compounds are water-soluble substances obtained from the sulfur-rich oil shale and represent the two fractions, which are the pale sulfonated shale oil (PSSO) and the dark sulfonated shale oil (DSSO), from the dry distillation process. The few available publications on bituminosulfonate involve a variety of microbial species in outdated research experiments and give only very limited insights on the in vitro mechanism and activity. A recent publication by Idelevich and Becker focused on the in vitro activity of sodium bituminosulfonate within the scope of current recommendations for antimicrobial susceptibility testing (AST), revealing activity against Gram-positive pathogens. [bold added for emphasis] [5]

    "Revival of old antibiotic compounds is a promising strategy to strengthen the antimicrobial armamentarium in the era of increasing resistance and limited development pipelines. To exploit their full potential, their reinvestigation using current standards is needed. We aimed to investigate the in vitro activity of the old antimicrobial agent sodium bituminosulfonate in accordance with the current recommendations for antimicrobial susceptibility testing (AST) and to generate susceptibility data reflecting the current epidemiological situation." [bold added for emphasis] [6]

    Sodium Sulfacetamide - Sulfur has been used to treat rosacea for many years. [7]

    Etcetera

    Sulphur or Sulfur for Rosacea

    End Notes

    [1] Dermatological medication and local therapeutics
    Christof Schaefer, Gudula Kirtschig, in Drugs During Pregnancy and Lactation (Third Edition), 2015, Ichthammol, Science Direct

    [2] Dermatopharmacology and Topical Formulary
    William L. Weston MD, ... Joseph G. Morelli MD, in Color Textbook of Pediatric Dermatology (Fourth Edition), 2007, Ichthammol, Science Direct

    [3] 

    If you cannot view the link above it is because you are not a registered, active member of the RRDi. Join the RRDi to view the article and become involved in our rosacea community. Learn more

    [4] Journal of Inflammation Research » Volume 14
    Sodium Bituminosulfonate Used to Treat Rosacea Modulates Generation of Inflammatory Mediators by Primary Human Neutrophils
    Susanne Schiffmann, Sandra Gunne, Marina Henke, Thomas Ulshöfer, Dieter Steinhilber, Annette Sethmann, Michael J Parnham 

    [5] Microorganisms, 8 December 2020; Published: 10 December 2020
    Investigation of In-Vitro Adaptation toward Sodium Bituminosulfonate in Staphylococcus aureus
    Marko Blisse, Evgeny A. Idelevich, and Karsten Becker 
    SBDS_microorganisms-08-01962-v2.pdf

    [6] Microb Drug Resist. 2020 Nov;26(11):1405-1409.  doi: 10.1089/mdr.2019.0390. Epub 2020 Mar 17.
    In Vitro Activity of Sodium Bituminosulfonate: Susceptibility Data for the Revival of an Old Antimicrobial
    Evgeny A Idelevich, Karsten Becker

    [7} Sodium Sulfacetamide - Sulfur

  2. 320px-Nice_Cup_of_Tea.jpg

    Usually, coffee is the trigger mentioned in rosacea social media groups, in any discussion about rosacea and sometimes even physicians mention coffee to their patients. However a recent study of 2063 participants (you should try to get that many participants together and get them to fill out a questionnaire) who were asked about tea consumption with their rosacea. The results of this study indicate, "non-fermented tea (aOR 2.172; 95% CI 1.562-3.022), and hot tea (aOR 2.793; 95% CI 1.796-1.344) were associated with an increased risk of rosacea. Further results showed that these tea drinking behaviours were significantly associated with an increased risk of flushing (aOR 1.41; 95% CI 1.07-1.87) and erythema (aOR 1.48; 95% CI 1.10-2.00). Tea drinking behaviour is closely related to rosacea." 

    RRDi Membership is free. Learn more. Image courtesy of Wikimedia Commons

     

     

  3. Watch this video to understand the final appeal. After you have seen this video, find the REPLY TO THIS TOPIC button or the QUOTE button (depending on your device, just keep scrolling till you find either button) to add your comment or question.  

    If you want to keep your privacy, simply type in a cryptic display name so no one knows who you are and post!  It is free!

  4. ACU-D1 is  a novel topical proteasome inhibitor discovered at Emory University that Accuitis, Inc. is developing as noted above in a clinical trial (NCT03064438). 

    Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Below is a cartoon representation of the 26S proteasome courtesy of Wikimedia Commons.

    137px-26S_proteasome_structure.jpg

    Canfield imaging has imaging systems used in dermatology which is used with the latest state of the art software/hardware that may improve diagnosing rosacea with computer aided technology. Below is the Canfield IntelliStudio

    Image 6-2-21 at 9.06 PM.jpg

  5. My current regimen is adding three ounces of Tea Tree Oil to a ten ounce bottle of baby shampoo. So the ratio of seven ounces of baby shampoo to three ounces of Tea Tree Oil works for me. I use this on my hair/face/body as a cleanser. I scrub my hair with a scrubber and rinse and then apply a second amount of this combination into my hair again because I have been suffering from folliculitis letting it set for a few minutes. I then rinse again. 

  6. "Finding and describing the cutaneous adverse reactions of the available COVID-19 vaccines has proved to be a challenging and difficult task. Injection site reactions presenting on the skin are among the most frequent adverse events, most of them mild or moderate, usually self-limited and without serious consequences. Delayed inflammatory reactions are less frequent but mysterious with no clear vision on the potential mechanisms leading to their appearance. Serious adverse events like VIPIT and anaphylaxis are of course the most important part of every safety and efficacy trial and the main topic of this article. Most of them are systemic adverse reactions with frequent cutaneous symptoms which may be the first manifestation and the key for the diagnosis leading to a timely and potentially life-saving treatment. Further vigilance for severe adverse reactions is mandatory after the beginning of the worldwide spread of the vaccines. The cutaneous findings are a very important part of this vigilance since they might be the first symptoms to detect. Their importance is frequently underestimated, and sometimes they are unreported in the clinical trials or considered irrelevant."

    Clin Dermatol. 2021 Apr 27
    Cutaneous adverse effects of the available COVID-19 vaccines
    Georgi Bogdano, MD, Ivan Bogdano, MD, Jana Kazandjieva, MD, and Nikolai Tsankov, MD, PhD

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